Gene interactions and pathways from curated databases and text-mining
CASP8: top 25 interacting genes (chr2:202125258-202152432)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only CASP8-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with CASP8, not among the Top 25
Other genes interacting with CASP8. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

AKT3 ▸ XIAP ▸ IL1B ▸ FASLG ▸ MAPK3 ▸ DIABLO ▸ IL1A ▸
BCL6 ▸ BCL3 ▸ BCL9 ▸ BCL5 ▸ EPHB2 ▸ MAPK1 ▸ IRF6 ▸
MAPK4 ▸ MAPK7 ▸ MAPK12 ▸ MAPK13 ▸ MAPK8 ▸ MAPK14 ▸ MAPK6 ▸
MAPK10 ▸ MAPK9 ▸ MAPK11 ▸ MAPK15 ▸ IFNG ▸ CASP3 ▸ APAF1 ▸
CAPN1 ▸ CAPN10 ▸ CAPN6 ▸ FADD ▸ CAPN2 ▸ CAPN9 ▸ IL18 ▸
CAPN12 ▸ CAPN8 ▸ CAPN11 ▸ CAPN7 ▸ CAPN5 ▸ CAPN3 ▸ CAPN15 ▸
CAPN13 ▸ CAPN14 ▸ STS ▸ ASIP ▸ DNTT ▸ MCL1 ▸ MMP9 ▸
MMP2 ▸ MMP11 ▸ MMP12 ▸ MMP3 ▸ MMP14 ▸ MMP8 ▸ NLRP3 ▸
MMP24 ▸ MMP20 ▸ MMP1 ▸ MMP27 ▸ MMP7 ▸ MMP13 ▸ MMP17 ▸
MMP15 ▸ MMP10 ▸ MMP21 ▸ MMP26 ▸ MMP25 ▸ MMP16 ▸ MMP19 ▸
CDKN1A ▸ MMP28 ▸ CASP9 ▸ JUN ▸ PDCD11 ▸ PDCD5 ▸ RNF19A ▸
CFLAR ▸ CASP12 ▸ PDCD2 ▸ PDCD10 ▸ PDCD7 ▸ PDCD6 ▸ PDCD1 ▸
PDCD4 ▸ CYCS ▸ NA ▸ CASP1 ▸ IGF1 ▸ ANXA5 ▸ CASP2 ▸
INS ▸ PCBD1 ▸ AHSA1 ▸ HLA-DRB1 ▸ MPZ ▸ CASP6 ▸ TGFB1 ▸
CASP7 ▸ NLRC4 ▸ PI3 ▸ PIK3CA ▸ EPO ▸ CASP4 ▸ CASP14 ▸
PIK3R1 ▸ CASP5 ▸ CASP16 ▸ CASP10 ▸ DDIT3 ▸ PRKCD ▸ TNFRSF1A ▸
DISC1 ▸ DFFA ▸ DISC2 ▸ NOS2 ▸ TAT ▸ PRDX2 ▸ CRK ▸
GRAP2 ▸ IL6 ▸ GSK3B ▸ PCNA ▸ MYLIP ▸ IL4 ▸ BIRC2 ▸
CTSB ▸ EGF ▸ CAST ▸ IRF1 ▸ VEGFA ▸ NOS1 ▸ SOD1 ▸
EIF2AK2 ▸ IL8 ▸ CTNNB1 ▸ DFFB ▸ BID ▸ LEP ▸ NGF ▸
PAK2 ▸ PTGS2 ▸ HGF ▸ DNASE2 ▸ APP ▸ ROCK1 ▸ ALPI ▸
DNASE1 ▸ P2RX7 ▸ ABL1 ▸ BCR ▸ RIPK1 ▸ CAT ▸ MYC ▸
APEH ▸ BDNF ▸ TCF4 ▸ IL16 ▸ FOS ▸ CDK2 ▸ IFI27 ▸
SOD2 ▸ IFNB1 ▸ MAP3K1 ▸ NOD2 ▸ TCF12 ▸ TCF25 ▸ TCF7 ▸
IL10 ▸ TLR2 ▸ BMP1 ▸ UPK3B ▸ HDAC2 ▸ TCF3 ▸ TCF19 ▸
TCF21 ▸ NFKBIA ▸ TCF20 ▸ CA2 ▸ TCF23 ▸ IL2 ▸ NOS3 ▸
TCF15 ▸ CSF2 ▸ CTSD ▸ MAP2K1 ▸ NOX1 ▸ HTRA2 ▸ RAC1 ▸
TCF24 ▸ NOX4 ▸ PRKDC ▸ BIRC7 ▸ AIM2 ▸ CSF3 ▸ ITIH4 ▸
ADCYAP1 ▸ BIRC3 ▸ HDAC1 ▸ STAT1 ▸ LMNB1 ▸ BAD ▸ TLR3 ▸
FGF2 ▸ TLR4 ▸ NLRP1 ▸ GAL ▸ POLDIP2 ▸ APOB ▸ ARSK ▸
HSPA5 ▸ CDC73 ▸ BMP4 ▸ SOD3 ▸ MAGT1 ▸ ATP5O ▸ CD8A ▸
CD79A ▸ TRAF6 ▸ NOX5 ▸ PML ▸ PPP2R1A ▸ PPP2CA ▸ RB1 ▸
RIPK2 ▸ TLR5 ▸ AGTR1 ▸ MST1 ▸ ENDOG ▸ CARD8 ▸ IL11 ▸
BMP10 ▸ IL15 ▸ WDR61 ▸ NOX3 ▸ LEO1 ▸ IL33 ▸ BMP6 ▸
BMP3 ▸ BMP5 ▸ BMP7 ▸ PPP2R2B ▸ GZMB ▸ BMP15 ▸ PDLIM7 ▸
IL3 ▸ STAT3 ▸ BMP2 ▸ KRT18 ▸ NOD1 ▸ SMPD2 ▸ HMGB1 ▸
IL5 ▸ TLR7 ▸ CTR9 ▸ CDK5 ▸ HSPB1 ▸ PAF1 ▸ SNAP25 ▸
HPR ▸ JAK2 ▸ IGF2 ▸ EIF2S1 ▸ PGP ▸ CD4 ▸ CREB1 ▸
CSE ▸ BOC ▸ SYK ▸ CCDC88A ▸ MET ▸ PTX3 ▸ TNFRSF1B ▸
IL20 ▸ RIPK3 ▸ TXN ▸ GSN ▸ RAD51 ▸ RBBP4 ▸ IL24 ▸
CDC6 ▸ EGFR ▸ CREB3 ▸ PPARA ▸ WAS ▸ HTT ▸ TLR10 ▸
NPS ▸ LPA ▸ TLR8 ▸ IL21 ▸ LMNB2 ▸ RBBP7 ▸ PRNP ▸
CREB5 ▸ CXCL9 ▸ PLCG1 ▸ HIF1A ▸ GP5 ▸ GP6 ▸ BIRC6 ▸
APC ▸ GP2 ▸ MAP2K2 ▸ TLR1 ▸ GP9 ▸ PTX4 ▸ ANXA1 ▸
ICAM1 ▸ CDH1 ▸ MSC ▸ ABCC6 ▸ SMPD1 ▸ PPARG ▸ IL25 ▸
MUC16 ▸ SMARCD1 ▸ MUC2 ▸ IRF3 ▸ TRAF1 ▸ BRCA1 ▸ IL9 ▸
MDM2 ▸ MUC19 ▸ ACHE ▸ IL22 ▸ RENBP ▸ ACTL6A ▸ IL27 ▸
ROCK2 ▸ IL19 ▸ MUC22 ▸ IKBKB ▸ MUC7 ▸ HSPD1 ▸ IL34 ▸
IL32 ▸ MUC8 ▸ SYT1 ▸ MUC17 ▸ SMARCC1 ▸ IL37 ▸ SMARCA4 ▸
CDA ▸ RAF1 ▸ SMARCA2 ▸ IL31 ▸ LYN ▸ CARD6 ▸ SMARCC2 ▸
TOP1 ▸ BECN1 ▸ MUC20 ▸ IL7 ▸ CD79B ▸ PAK1 ▸ FOXO3 ▸
MUC6 ▸ SMARCB1 ▸ GATA1 ▸ UCN ▸ MUC4 ▸ CCL2 ▸ CDK8 ▸
MEFV ▸ SMARCE1 ▸ CARD11 ▸ TLR9 ▸ IL26 ▸ PLD1 ▸ MUC12 ▸
ANGPT2 ▸ MUC1 ▸ TLR6 ▸ MUC15 ▸ MUC13 ▸ STX1A ▸ CARD9 ▸
CCND1 ▸ KDR ▸ MUC21 ▸ RRAS ▸ IL13 ▸ SMARCD2 ▸ HMOX1 ▸
ARID1A ▸ CEP250 ▸ PSEN1 ▸ NUP153 ▸ NPM1 ▸ GRB10 ▸ CEP152 ▸
GRK6 ▸ CEP350 ▸ CARD10 ▸ CEP85 ▸ PTHLH ▸ IKBKG ▸ CD40 ▸
NPY6R ▸ PXN ▸ GUCY2D ▸ CEP57 ▸ CARD18 ▸ HSF1 ▸ DERL1 ▸
NUP210 ▸ GRK5 ▸ SEC14L2 ▸ CEP135 ▸ PRKAR1B ▸ TARDBP ▸ GDNF ▸
HIP1 ▸ CCR7 ▸ CEP104 ▸ GRB7 ▸ PTK2 ▸ CDK4 ▸ CARD17 ▸
CEP78 ▸ IRF4 ▸ VDAC1 ▸ WNT1 ▸ GRK4 ▸ PLOD2 ▸ CEP192 ▸
SETD2 ▸ TRAF2 ▸ CEP97 ▸ PANX1 ▸ IL1RN ▸ SKP1 ▸ CD47 ▸
MAP2K6 ▸ CEP41 ▸ CUL1 ▸ PRKACB ▸ DST ▸ H2AFX ▸ TNFRSF10A ▸
BIRC5 ▸ MIF ▸ PLD2 ▸ PRKACG ▸ ARC ▸ PRKCG ▸ VIMP ▸
CEP76 ▸ VCP ▸ MAP2K7 ▸ PRKAR2A ▸ CEP170 ▸ GRK7 ▸ E2F1 ▸
IGF1R ▸ BIRC8 ▸ CARD16 ▸ CEP72 ▸ SLC17A5 ▸ EHMT1 ▸ ANGPT1 ▸
CEP112 ▸ CEP120 ▸ CEP19 ▸ PRKAR1A ▸ CEP164 ▸ EPX ▸ CALM3 ▸
PRKAR2B ▸ DES ▸ PTBP1 ▸ RASA1 ▸ VIM ▸ ARSA ▸ NUP62 ▸
CEP128 ▸ GRB14 ▸ LYPLA1 ▸ CEP44 ▸ ELAVL1 ▸ CEP95 ▸ MEPE ▸
LAT ▸ SLCO6A1 ▸ GRK1 ▸ SP1 ▸ TRAF3 ▸ PSMD10 ▸ ME2 ▸
CEP55 ▸ ADIPOQ ▸ NUP214 ▸ CEP290 ▸ ALB ▸ PEA15 ▸ CEP70 ▸
TCHP ▸ IRF2 ▸ ALK ▸ CEP63 ▸ CARD14 ▸ CEP89 ▸ HUNK ▸
ATG5 ▸ MAP2K5 ▸ SOAT1 ▸ SLC9A1 ▸ MAP2K4 ▸ PTEN ▸ PIDD ▸
GRB2 ▸ IRF5 ▸ MAP2K3 ▸ BCL2L12 ▸ BACE1 ▸ MPST ▸ PRKCA ▸
CEP68 ▸ HSP90AA1 ▸ FOXO1 ▸ SETBP1 ▸ HIST2H2BE ▸ MED15 ▸ RAC3 ▸
NAB1 ▸ TRAF7 ▸ RAD21 ▸ APIP ▸ HDAC6 ▸ GPX1 ▸ AIP ▸
RAC2 ▸ CALB1 ▸ MED26 ▸ GLI1 ▸ C22orf29 ▸ ANXA6 ▸ PLK1 ▸
CTSL ▸ FAM168B ▸ STSP1 ▸ GRP ▸ MED17 ▸ HCLS1 ▸ MED13 ▸
LRP1 ▸ ATF2 ▸ MT4 ▸ CCR9 ▸ CXCL13 ▸ LGALS1 ▸ SMAD7 ▸
GSTT1 ▸ MME ▸ IRF9 ▸ THBS1 ▸ CDK9 ▸ DYRK1A ▸ IFI44 ▸
SERPINA1 ▸ APOBEC3D ▸ GNRH1 ▸ CDC42 ▸ RHO ▸ MED4 ▸ PNPLA2 ▸
ADH5 ▸ ACIN1 ▸ RAD1 ▸ CHUK ▸ TGFB3 ▸ CCNH ▸ NTN1 ▸
SREBF1 ▸ TET3 ▸ CDK12 ▸ HRD ▸ ACSM3 ▸ GPI ▸ DAXX ▸
MLYCD ▸ DLG1 ▸ RAD52 ▸ MED1 ▸ TRA ▸ CRYAB ▸ TRAF4 ▸
STX2 ▸ ITCH ▸ ETS1 ▸ KLKB1 ▸ JAK3 ▸ APOE ▸ NR0B1 ▸
MAP3K7 ▸ NUP43 ▸ MED24 ▸ PARG ▸ FOXP3 ▸ NLRC5 ▸ ANG ▸
QRICH2 ▸ CCR5 ▸ CCR2 ▸ NACA ▸ CYR61 ▸ FAF1 ▸ RAD17 ▸
GNA11 ▸ IRF8 ▸ NPPA ▸ CAPNS1 ▸ APEX1 ▸ ING1 ▸ IAPP ▸
HRK ▸ CA8 ▸ CCR6 ▸ RAB5A ▸ PAN3 ▸ GJA1 ▸ TET1 ▸
MED12 ▸ CDK7 ▸ IFIH1 ▸ ODC1 ▸ PRKAB2 ▸ TET2 ▸ PIN1 ▸
CTNNBL1 ▸ EIF4G2 ▸ HTRA4 ▸ NTF3 ▸ EMP2 ▸ SDS ▸ NLRP7 ▸
CDCA5 ▸ GHSR ▸ IARS ▸ TNFRSF10B ▸ TNFRSF8 ▸ PSENEN ▸ S100A12 ▸
HTRA1 ▸ CCR10 ▸ MED14 ▸ TSC22D3 ▸ VDAC3 ▸ BCAP31 ▸ SIVA1 ▸
SERP2 ▸ CDK14 ▸ NTF4 ▸ CALR ▸ CCNC ▸ LRRC59 ▸ PRKAA1 ▸
DAPK2 ▸ CCR1 ▸ CFTR ▸ CDK10 ▸ EIF4G1 ▸ NAIP ▸ E2F3 ▸
MED7 ▸ CXCL17 ▸ ZGLP1 ▸ CD2 ▸ PC ▸ HIPK2 ▸ PLD6 ▸
TIMP3 ▸ MTA3 ▸ PRG3 ▸ HDAC4 ▸ TNFSF12 ▸ CDK15 ▸ NANOS2 ▸
FUT1 ▸ CDK18 ▸ SMAD4 ▸ MAP2 ▸ PLD5 ▸ GPX3 ▸ TAC3 ▸
CDK13 ▸ RAD50 ▸ VDAC2 ▸ EMP1 ▸ SRC ▸ AFP ▸ GYS2 ▸
IFNA2 ▸ E2F2 ▸ CDK6 ▸ CDK20 ▸ SHC1 ▸ PPT1 ▸ EDNRA ▸
CD8B ▸ CALML3 ▸ CDK17 ▸ TYR ▸ ATM ▸ PTPN11 ▸ MED6 ▸
EEF1A2 ▸ DHCR24 ▸ BLM ▸ BAG3 ▸ CDK3 ▸ CPA1 ▸ EML2 ▸
CDK19 ▸ COP ▸ CPOX ▸ MED21 ▸ CTNND1 ▸ SMAD3 ▸ CFL1 ▸
UCP2 ▸ CIB1 ▸ MTA1 ▸ PLD3 ▸ CDK1 ▸ XAF1 ▸ CCR8 ▸
PGF ▸ MT3 ▸ CSF1 ▸ MTA2 ▸ PAEP ▸ PTCH1 ▸ QRICH1 ▸
TAC4 ▸ GYS1 ▸ ERVK-6 ▸ MICE ▸ PRKAB1 ▸ PLD4 ▸ TAC1 ▸
VIP ▸ RANBP2 ▸ ATG3 ▸ PSMB9 ▸ TMED7 ▸ JAK1 ▸ RIPK4 ▸
HMGCR ▸ SERPINF1 ▸ STC1 ▸ PDGFB ▸ SERPINB9 ▸ SUB1 ▸ ACAD8 ▸
CENPK ▸ TFAP2A ▸ WNT3A ▸ CCR4 ▸ RBL2 ▸ EIF4G3 ▸ ATF5 ▸
PRKAA2 ▸ IGFBP3 ▸ PRG2 ▸ DNAJC5 ▸ WNK1 ▸ NAB2 ▸ CCR3 ▸
KLK3 ▸ BNIP3 ▸ MED25 ▸ NUAK1 ▸ PPP1R3A ▸ RARA ▸ SPP1 ▸
HTRA3 ▸ TRAF5 ▸ SAA1 ▸ MED8 ▸ FHIT ▸ ABCD1 ▸ CDK16 ▸
NLRP5 ▸ KMT2A ▸ MTOR ▸ PMEL ▸ CCL19 ▸ XRCC6 ▸ CISH ▸
SATB1 ▸ NANOG ▸ ID3 ▸ SEPT4 ▸ IRS1 ▸ DIDO1 ▸ ETS2 ▸
MST1R ▸ TGM2 ▸ IDO1 ▸ EMP3 ▸ SREBF2 ▸ RAD18 ▸ PAN2 ▸
PRKAG1 ▸ RUNX3 ▸ KLF4 ▸ DAP3 ▸ PRKAG2 ▸ CTRL ▸ IRF7 ▸
ADM ▸ ANP32A ▸ PRG4 ▸ CCK ▸ SLPI ▸ MED23 ▸ TUBA1C ▸
CASP8AP2 ▸ NOL3 ▸ UBC ▸ UBB ▸ PICALM ▸ RNF135 ▸ NR1H4 ▸
ACTA2 ▸ EZR ▸ PLEC ▸ TUBA1A ▸ CD247 ▸ COL5A2 ▸ COL11A2 ▸
EIF4A1 ▸ COL1A1 ▸ COPS6 ▸ KARS ▸ RPS27L ▸ TOPORS ▸ UBE2D1 ▸
ITGA2 ▸ TRIM28 ▸ CHD3 ▸ ATN1 ▸ COL1A2 ▸ OTUD7B ▸ PDIA6 ▸
MALT1 ▸ COL4A4 ▸ RAB10 ▸ NEFH ▸ ARHGDIA ▸ IL1R2 ▸ SYF2 ▸
PTPN13 ▸ DNAJC7 ▸ CLIP3 ▸ PYCARD ▸ MSN ▸ COL6A1 ▸ DEDD2 ▸
PIAS1 ▸ COL7A1 ▸ PCYT1A ▸ COL5A1 ▸ RALBP1 ▸ COL6A3 ▸ IQGAP1 ▸
PLA2G4B ▸ MAP3K14 ▸ ITGB3 ▸ BNIP3L ▸ AR ▸ ATG4D ▸ NCL ▸
COL4A6 ▸ SQSTM1 ▸ RALGDS ▸ MAPT ▸ PARK7 ▸ CD3G ▸ ACTG2 ▸
PTPN6 ▸ EP300 ▸ TUBB ▸ ITGB1 ▸ EDA2R ▸ PRKCI ▸ BFAR ▸
MAP4K4 ▸ UBE2L3 ▸ TRIM25 ▸ CDK11B ▸ HNRNPH2 ▸ CDK11A ▸ COL4A1 ▸
ITGAV ▸ TNFRSF25 ▸ COL11A1 ▸ SPARC ▸ MAP1LC3A ▸ MYO9A ▸ PARK2 ▸
USP54 ▸ TICAM2 ▸ NUCB2 ▸ ATAD3A ▸ KHDRBS1 ▸ MAP1LC3B ▸ CUL3 ▸
RPS27 ▸ IL1R1 ▸ TNFAIP3 ▸ CLTC ▸ PLIN4 ▸ TFCP2 ▸ EIF3S10 ▸
COL4A5 ▸ HIST1H4A ▸ KRR1 ▸ CD3E ▸ IFT57 ▸ CD3D ▸ RNF34 ▸
COL3A1 ▸ COL2A1 ▸ SORBS1 ▸ STK24 ▸ CD14 ▸ FIS1 ▸ GRIA1 ▸
IRS4 ▸ COL6A2 ▸ CRADD ▸ LY96 ▸ YES1 ▸ NUCB1 ▸ PIDD1 ▸
UBR5 ▸ USP2 ▸ TNFSF14 ▸ DDX28 ▸ COL4A3 ▸
Data information
Please see the Gene Interactions Track Manual.