This file is from: http://hgdownload.cse.ucsc.edu/goldenPath/rn5/phastCons13way/README.txt This directory contains compressed phastCons scores for multiple alignments of 12 vertebrate genomes to the rat genome. Files in this directory are: rn5.13way.phastCons.mod - phastCons tree model for all 13 species phastCons scores in bigWig format files: rn5.13way.phastCons.bw - all 13 species See also: http://genome.ucsc.edu/FAQ/FAQformat.html#format6.1 for bigWig format description phastCons scores in fixed step wiggle format files: phastCons13way.wigFix.gz - phastCons scores for 13 species For a description of the phastCons fixed step wiggle data file format, see: http://genome.ucsc.edu/goldenPath/help/phastCons.html The phastCons data can be found at: http://hgdownload.cse.ucsc.edu/goldenPath/rn5/phastCons13way/ The multiple alignments and methods description are at: http://hgdownload.cse.ucsc.edu/goldenPath/rn5/multiz13way/ For more information about this data, see the track description for the Conservation track: http://genome.ucsc.edu/cgi-bin/hgTrackUi?db=rn5&g=cons13way Assemblies used in these alignments: Rat Rattus norvegicus Mar 2012 RGSC 5.0/rn5 Reference species Chicken Gallus gallus Nov 2011 ICGSC Gallus_gallus-4.0/galGal4 Net Chimp Pan troglodytes Feb 2011 CSAC 2.1.4/panTro4 Syntenic net Cow Bos taurus Oct 2011 Baylor Btau_4.6.1/bosTau7 Syntenic net Dog Canis lupus familiaris Sep 2011 Broad CanFam3.1/canFam3 Syntenic net Guinea pig Cavia porcellus Feb 2008 Broad/cavPor3 Syntenic net Human Homo sapiens Dec 2013 GRCh38/hg38 Syntenic net Mouse Mus musculus Dec 2011 GRCm38/mm10 Syntenic net Opossum Monodelphis domestica Oct 2006 Broad/monDom5 Net Panda Ailuropoda melanoleuca Dec 2009 BGI-Shenzhen 1.0/ailMel1 Reciprocal best Rhesus Macaca mulatta Oct 2010 BGI CR_1.0/rheMac3 Syntenic net Turkey Meleagris gallopavo Dec 2009 TGC Turkey_2.01/melGal1 Net Zebrafish Danio rerio Jul 2010 Zv9/danRer7 Net --------------------------------------------------------------- To download a large file or multiple files from this directory, we recommend that you use rsync or ftp rather than downloading the files via our website. There is approximately 6.7 Gb of compressed data in this directory. Via rsync: rsync -avz --progress \ rsync://hgdownload.cse.ucsc.edu/goldenPath/rn5/phastCons13way/ ./ Via FTP: ftp hgdownload.cse.ucsc.edu user name: anonymous password: go to the directory goldenPath/rn5/phastCons13way To download multiple files from the UNIX command line, use the "mget" command. mget ... - or - mget -a (to download all the files in the directory) Use the "prompt" command to toggle the interactive mode if you do not want to be prompted for each file that you download. --------------------------------------------------------------- All the files in this directory are freely available for public use. For data use restrictions regarding the genome assemblies used in this annotation, see http://genome.ucsc.edu/goldenPath/credits.html. --------------------------------------------------------------- References for phastCons and phyloP: Pollard KS, Hubisz MJ, Siepel A. Detection of non-neutral substitution rates on mammalian phylogenies. Genome Res. 2010 Jan;20(1):110-21. (http://genome.cshlp.org/content/early/2009/10/26/gr.097857.109.abstract) Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, Rosenbloom K, Clawson H, Spieth J, Hillier LW, Richards S, et al. Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res. 2005 Aug;15(8):1034-50. (http://genome.cshlp.org/content/15/8/1034)