This file is from: http://hgdownload.cse.ucsc.edu/goldenPath/monDom5/phastCons9way/README.txt This directory contains compressed phastCons scores for multiple alignments of 9 vertebrate genomes to the opossum genome. Files in this directory are: ave.cons.mod ave.noncons.mod phastCons tree models with branch lengths for all nine species wig/chr*.wig.gz per-chromosome phastCons scores for all 9 species The multiple alignments and methods description are at: http://hgdownload.cse.ucsc.edu/goldenPath/monDom5/multiz9way/ For a description of the phastCons data file format, see http://genome.ucsc.edu/goldenPath/help/phastCons.html Assemblies used in these alignments: _ Opossum Monodelphis domestica Oct. 2006 monDom5 _ Wallaby Macropus eugenii Nov. 2007 macEug1 _ Human Homo sapiens Mar. 2006 hg18 _ Mouse Mus musculus July 2007 mm9 _ Dog Canis lupus familiaris May 2005 canFam2 _ Platypus Ornithorhynchus anatinus Mar. 2007 ornAna1 _ Chicken Gallus gallus May 2006 galGal3 _ X. tropicalis Xenopus tropicalis Aug. 2005 xenTro2 _ Zebrafish Danio rerio July 2007 danRer5 --------------------------------------------------------------- To download a large file or multiple files from this directory, we recommend that you use rsync or ftp rather than downloading the files via our website. There is approximately 3.8 Gb of compressed data in this directory. Via rsync: rsync -avz --progress \ rsync://hgdownload.cse.ucsc.edu/goldenPath/monDom5/phastCons9way/ ./ Via FTP: ftp hgdownload.cse.ucsc.edu user name: anonymous password: go to the directory goldenPath/monDom5/phastCons9way To download multiple files from the UNIX command line, use the "mget" command. mget ... - or - mget -a (to download all the files in the directory) Use the "prompt" command to toggle the interactive mode if you do not want to be prompted for each file that you download. --------------------------------------------------------------- All the files in this directory are freely available for public use. For data use restrictions regarding the genome assemblies used in this annotation, see http://genome.ucsc.edu/goldenPath/credits.html. --------------------------------------------------------------- References for phastCons: Siepel, A., Bejerano, G., Pedersen, J.S., Hinrichs, A., Hou, M., Rosenbloom, K., Clawson, H., Spieth, J., Hillier, L.W., Richards, S., Weinstock, G.M., Wilson, R. K., Gibbs, R.A., Kent, W.J., Miller, W., and Haussler, D. Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res. 15, 1034-1050 (2005). (http://www.genome.org/cgi/doi/10.1101/gr.3715005) Siepel, A. and Haussler, D. Phylogenetic hidden Markov models. In R. Nielsen, ed., Statistical Methods in Molecular Evolution, Springer (in press) (2004).