This file is from: http://hgdownload.cse.ucsc.edu/goldenPath/mm10/phyloP60way/README.txt This directory contains conservation scoring by phyloP (phylogenetic p-values) from the PHAST package (http://compgen.bscb.cornell.edu/phast/) for multiple alignments of 59 vertebrate genomes to the mouse genome, plus three alternate sets of scores for subsets of species in the alignments. Files in this directory are: mm10.phyloP.glire.mod - tree model for the glire subset: mm10 cavPor3 dipOrd1 hetGla2 ochPri2 oryCun2 rn5 speTri2 mm10.phyloP.euarchontoglire.mod - tree model for the euarchontoglire subset, including the glire subset above plus: tupBel1 calJac3 gorGor3 hg19 micMur1 nomLeu2 otoGar3 panTro4 papHam1 ponAbe2 rheMac3 saiBol1 tarSyr1 mm10.phyloP.placental.mod - tree model for the placental subset, including the glire and euarchontoglire subsets above plus: ailMel1 bosTau7 canFam3 choHof1 dasNov3 echTel1 equCab2 eriEur1 felCat5 loxAfr3 myoLuc2 oviAri1 proCap1 pteVam1 sorAra1 susScr3 triMan1 turTru2 vicPac1 mm10.phyloP.60way.mod - phyloP tree model with branch lengths for all 60 species: the glire, euarchontoglire and placental sets above plus: anoCar2 chrPic1 danRer7 fr3 gadMor1 galGal4 gasAcu1 latCha1 macEug2 melGal1 melUnd1 monDom5 oreNil2 ornAna1 oryLat2 petMar1 sarHar1 taeGut1 tetNig2 xenTro3 PhyloP scores in bigWig format files: mm10.60way.phyloP60way.bw mm10.60way.phyloP60wayGlire.bw mm10.60way.phyloP60wayEuarchontoglire.bw mm10.60way.phyloP60wayPlacental.bw See also: http://genome.ucsc.edu/FAQ/FAQformat.html#format6.1 for bigWig format description PhyloP scores in fixed step wiggle format: mm10.60way.phyloP60way/*.wigFix.gz - phyloP scores for all 60 species glire/*.wigFix.gz - phyloP scores for the glire subset euarchontoglire/*.wigFix.gz - phyloP scores for the euarchontoglire subset placental/*.wigFix.gz - phyloP scores for the placental subset For a description of the fixed step wiggle data file format, see: http://genome.ucsc.edu/goldenPath/help/phastCons.html The phastCons data can be found at: http://hgdownload.cse.ucsc.edu/goldenPath/mm10/phastCons60way/ The multiple alignments and methods description are at: http://hgdownload.cse.ucsc.edu/goldenPath/mm10/multiz60way/ For more information about this data, see the track description for the Conservation track: http://genome.ucsc.edu/cgi-bin/hgTrackUi?db=mm10&g=cons60way Assemblies used in these alignments: ==== Glire subset: Mouse Mus musculus Dec. 2011 GRCm38/mm10 reference Guinea pig Cavia porcellus Feb. 2008 Broad/cavPor3 Syntenic net Kangaroo rat Dipodomys ordii Jul. 2008 Broad/dipOrd1 Reciprocal best Naked mole-rat Heterocephalus glaber Jan. 2012 Broad HetGla_female_1.0/hetGla2 Syntenic net Pika Ochotona princeps Jul. 2008 Broad/ochPri2 Reciprocal best Rabbit Oryctolagus cuniculus Apr. 2009 Broad/oryCun2 Syntenic net Rat Rattus norvegicus Mar. 2012 RGSC 5.0/rn5 Syntenic net Squirrel Spermophilus tridecemlineatus Nov. 2011 Broad/speTri2 Syntenic net ==== Euarchontoglire subset, includes the glire subset above plus: Tree shrew Tupaia belangeri Dec. 2006 Broad/tupBel1 Reciprocal best Marmoset Callithrix jacchus Mar. 2009 WUGSC 3.2/calJac3 Syntenic net Gorilla Gorilla gorilla May. 2011 gorGor3 Syntenic net Human Homo sapiens Feb. 2009 GRCh37/hg19 Syntenic net Mouse lemur Microcebus murinus Jun. 2003 Broad/micMur1 Reciprocal best Gibbon Nomascus leucogenys Jun. 2011 GGSC Nleu1.1/nomLeu2 Syntenic net Bushbaby Otolemur garnettii Mar. 2011 Broad/otoGar3 Syntenic net Chimp Pan troglodytes Feb. 2011 Pan_troglodytes-2.1.4/panTro4 Syntenic net Baboon Papio hamadryas Nov. 2008 Baylor 1.0/papHam1 Reciprocal best Orangutan Pongo pygmaeus abelii July 2007 WUGSC 2.0.2/ponAbe2 Syntenic net Chinese rhesus Macaca mulatta Oct. 2010 BGI CR_1.0/rheMac3 Syntenic net Squirrel monkey Saimiri boliviensis Oct. 2011 saiBol1 Syntenic net Tarsier Tarsius syrichta Aug. 2008 Broad/tarSyr1 Reciprocal best ==== Placental subset, includes the glire and euarchontoglire subset above plus: Panda Ailuropoda melanoleuca Dec. 2009 BGI-Shenzhen 1.0/ailMel1 Syntenic Net Cow Bos taurus Oct. 2011 Baylor Btau_4.6.1/bosTau7 Syntenic Net Dog Canis lupus familiaris Sep. 2011 Broad/canFam3) Syntenic net Sloth Choloepus hoffmanni Jul. 2008 Broad//choHof1 Reciprocal best Armadillo Dasypus novemcinctus Dec. 2011 Armadillo/dasNov3 Reciprocal best Tenrec Echinops telfairi Jul. 2005 Broad/echTel1 Reciprocal best Horse Equus caballus Sep. 2007 Broad/equCab2 Syntenic net Hedgehog Erinaceus europaeus Jun. 2006 Broad/eriEur1 Reciprocal best Cat Felis catus Sep. 2011 ICGSC Felis_catus 6.2/felCat5 Reciprocal best Elephant Loxodonta africana Jul. 2009 Broad/loxAfr3 Syntenic net Microbat Myotis lucifugus Jul. 2010 Broad/myoLuc2 Reciprocal best Sheep Ovis aries Feb. 2010 ISGC/oviAri1 Reciprocal best Rock hyrax Procavia capensis Jul. 2008 Broad/proCap1 Reciprocal best Megabat Pteropus vampyrus Jul. 2008 Broad/pteVam1 Reciprocal best Shrew Sorex araneus Jun. 2006 Broad/sorAra1 Reciprocal best Pig Sus scrofa Aug. 2011 SGSC Sscrofa10.2/susScr3 Syntenic net Manatee Trichechus manatus latirostris Oct. 2011 Broad v1.0/triMan1 Syntenic net Dolphin Tursiops truncatus Oct. 2011 Baylor Ttru_1.4/turTru2 Reciprocal best Alpaca Vicugna pacos Jul. 2008 Broad/vicPac1 Reciprocal best ==== the rest of the vertebrates with the above complete the full 60-way species: Lizard Anolis carolinensis May 2010 Broad/anoCar2 net Painted turtle Chrysemys picta bellii Dec. 2011 v3.0.1/chrPic1 net Zebrafish Danio rerio Jul. 2010 Zv9/danRer7 net Fugu Takifugu rubripes Oct. 2011 FUGU5/fr3 net Atlantic cod Gadus morhua May. 2010 Genofisk GadMor_May2010/gadMor1 net Chicken Gallus gallus Nov. 2011 ICGSC Gallus_gallus-4.0/galGal4 net Stickleback Gasterosteus aculeatus Feb. 2006 Broad/gasAcu1 net Coelacanth Latimeria chalumnae Aug. 2011 latCha1 net Wallaby Macropus eugenii Sep. 2009 TWGS Meug_1.1/macEug2 Reciprocal best Turkey Meleagris gallopavo Dec. 2009 TGC Turkey_2.01/melGal1 net Budgerigar Melopsittacus undulatus Sep. 2011 WUSTL v6.3/melUnd1 net Opossum Monodelphis domestica Oct. 2006 Broad/monDom5 net Nile tilapia Oreochromis niloticus Jan. 2011 Nile tilapia/oreNil2 net Platypus Ornithorhynchus anatinus Mar. 2007 WUGSC 5.0.1/ornAna1 net Medaka Oryzias latipes Oct. 2005 NIG/UT MEDAKA1/oryLat2 net Lamprey Petromyzon marinus Mar. 2007 WUGSC 3.0/petMar1 net Tasmanian devil Sarcophilus harrisii Feb. 2011 WTSI Devil_ref v7.0/sarHar1 net Zebra finch Taeniopygia guttata Jul. 2008 WUGSC 3.2.4/taeGut1 net Tetraodon Tetraodon nigroviridis Mar. 2007 Genoscope 8.0/tetNig2 net X. tropicalis Xenopus tropicalis Nov. 2009 JGI 4.2/xenTro3 net --------------------------------------------------------------- To download a large file or multiple files from this directory, we recommend that you use rsync or ftp rather than downloading the files via our website: rsync -avz --progress \ rsync://hgdownload.cse.ucsc.edu/goldenPath/mm10/phyloP60way/ ./ OR ftp hgdownload.cse.ucsc.edu user name: anonymous password: go to the directory goldenPath/mm10/phyloP60way To download multiple files from the UNIX command line, use the "mget" command. mget ... - or - mget -a (to download all the files in the directory) Use the "prompt" command to toggle the interactive mode if you do not want to be prompted for each file that you download. --------------------------------------------------------------- All the files in this directory are freely available for public use. For data use restrictions regarding the genome assemblies used in this annotation, see http://genome.ucsc.edu/goldenPath/credits.html. --------------------------------------------------------------- References for phastCons and phyloP: Pollard KS, Hubisz MJ, Siepel A. Detection of non-neutral substitution rates on mammalian phylogenies. Genome Res. 2010 Jan;20(1):110-21. (http://genome.cshlp.org/content/early/2009/10/26/gr.097857.109.abstract) Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, Rosenbloom K, Clawson H, Spieth J, Hillier LW, Richards S, et al. Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res. 2005 Aug;15(8):1034-50. (http://www.genome.org/cgi/doi/10.1101/gr.3715005)