This file is from:

    http://hgdownload.cse.ucsc.edu/goldenPath/hg38/phastCons7way/README.txt

This directory contains compressed phastCons scores for multiple alignments
of 6 vertebrate genomes to the human genome.

Files in this directory:

  hg38.phastCons7way.mod - phastCons tree model for the 7 species
  hg38.phastCons7way.wigFix.gz - scores in fixed step wiggle format
  hg38.phastCons7way.bw - scores in bigWig format files:

See also: http://genome.ucsc.edu/FAQ/FAQformat.html#format6.1
   for bigWig format description

For a description of the phastCons fixed step wiggle data file format, see:
http://genome.ucsc.edu/goldenPath/help/phastCons.html

The phyloP data can be found at:
http://hgdownload.cse.ucsc.edu/goldenPath/hg38/phyloP7way/

The multiple alignments and methods description are at:
http://hgdownload.cse.ucsc.edu/goldenPath/hg38/multiz7way/

Assemblies used in these alignments:                                 (alignment
                                                                           type)

Human - Homo sapiens                Dec. 2013 (GRCh38/hg38)           reference
Chimp - Pan troglodytes             Feb. 2011 (GSAC 2.1.4/panTro4)     syntenic
Rhesus - Macaca mulatta             Oct. 2010 (BGI CR_1.0/rheMac3)     syntenic
Dog - Canis lupus familiaris        Sep. 2011 (Broad/canFam3)          syntenic
Mouse - Mus musculus                Dec. 2011 (GRCm38/mm10)            syntenic
Rat - Rattus norvegicus             Mar. 2012 (RGSC Rnor 5.0/rn5)      syntenic
Opossum - Monodelphis domestica     Oct. 2006 (Broad/monDom5)               net


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To download a large file or multiple files from this directory, we recommend 
that you use rsync or ftp rather than downloading the files via our website.
There is approximately 8.5 Gb of compressed data in this directory.

Via rsync:
rsync -avz --progress \
	rsync://hgdownload.cse.ucsc.edu/goldenPath/hg38/phastCons7way/ ./

Via FTP:
    ftp hgdownload.cse.ucsc.edu 
    user name: anonymous
    password: <your email address>
    go to the directory goldenPath/hg38/phastCons7way

To download multiple files from the UNIX command line, use the "mget" command. 
    mget <filename1> <filename2> ...
    - or -
    mget -a (to download all the files in the directory) 
Use the "prompt" command to toggle the interactive mode if you do not want 
to be prompted for each file that you download.

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All the files in this directory are freely available for public use.
For data use restrictions regarding the genome assemblies used in this
annotation, see http://genome.ucsc.edu/goldenPath/credits.html.

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References for phastCons and phyloP:

Pollard KS, Hubisz MJ, Siepel A. Detection of non-neutral substitution rates
on mammalian phylogenies. Genome Res. 2009 Oct 26. [Epub ahead of print]
(http://genome.cshlp.org/content/early/2009/10/26/gr.097857.109.abstract)

Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, Rosenbloom K, Clawson
H, Spieth J, Hillier LW, Richards S, et al. Evolutionarily conserved elements
in vertebrate, insect, worm, and yeast genomes. Genome Res. 2005
Aug;15(8):1034-50.  (http://www.genome.org/cgi/doi/10.1101/gr.3715005)

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