This directory contains compressed phastCons scores for multiple alignments of the following assemblies to the Human May 2004 (hg17) genome: - Chimp (panTro1, Nov. 2003) - Dog (canFam1, Jul. 2004) - Mouse (mm5, May 2004) - Rat (rn3, Jun. 2003) - Chicken (galGal2, Feb. 2004) - Zebrafish (danRer1, Nov. 2003) - Fugu (fr1, Aug. 2002) For a description of the phastCons data format, see http://genome.ucsc.edu/goldenPath/help/phastCons.html. ---------------------------------------------------------------------- References for phastCons: Siepel, A., Bejerano, G., Pedersen, J.S., Hinrichs, A., Hou, M., Rosenbloom, K., Clawson, H., Spieth, J., Hillier, L.W., Richards, S., Weinstock, G.M., Wilson, R. K., Gibbs, R.A., Kent, W.J., Miller, W., and Haussler, D. Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res. 15, 1034-1050 (2005). (http://www.genome.org/cgi/doi/10.1101/gr.3715005) Siepel, A. and Haussler, D. Phylogenetic hidden Markov models. In R. Nielsen, ed., Statistical Methods in Molecular Evolution, Springer (in press) (2004). For a discussion of the methods used to calculate the phastCons scores, see the description page for the hg17 Conservation track in the Genome Browser.