This file is from: http://hgdownload.cse.ucsc.edu/goldenPath/felCat4/multiz6way/README.txt This directory contains compressed multiple alignments of of 5 mammal genomes to the cat genome (felCat4, Dec. 2008). Assemblies used in these alignments: - Cat Felis catus Dec 2008 felCat4 reference - Dog Canis lupus familiaris May 2005 canFam2 chain net - Panda Ailuropoda melanoleuca Dec 2009 ailMel1 recip best - Human Homo sapiens Feb 2009 hg19 chain net - Mouse Mus musculus Jul 2007 mm9 chain net - Opossum Monodelphis domestica Oct 2006 monDom5 chain net These alignments were prepared using the methods described in the track description file: http://genome.ucsc.edu/cgi-bin/hgTrackUi?db=felCat4&g=cons6way based on the phylogenetic tree: 6way.nh. Files in this directory: - 6way.nh - phylogenetic tree used during the multiz multiple alignment - commonNames.6way.nh - same as 6way.nh with the UCSC database name replaced by the common name for the species The felCat4.6way.maf.gz file contains all the alignments for all chromosomes and contigs in the cat genome. Beware, the compressed data size of this file is 2.2 GB. The upstream*.maf.gz files contain alignments in regions upstream of annotated transcription starts for nscan genes with annotated 5' UTRs. These files differ from the standard MAF format: they display alignments that extend from start to end of the upstream region in human, whether or not alignments actually exist. In situations where no alignments exist or the alignments of one or more species are missing, dot (".") is used as a placeholder. Multiple regions of an assembly's sequence may align to a single region in human; therefore, only the species name is displayed in the alignment data and no position information is recorded. The alignment score is always zero in these files. These files are updated weekly. For a description of multiple alignment format (MAF), see http://genome.ucsc.edu/goldenPath/help/maf.html. PhastCons conservation scores for these alignments are available at: http://hgdownload.cse.ucsc.edu/goldenPath/felCat4/phastCons6way PhyloP conservation scores for these alignments are available at: http://hgdownload.cse.ucsc.edu/goldenPath/felCat4/phyloP6way --------------------------------------------------------------- To download a large file or multiple files from this directory, we recommend that you use rsync or ftp rather than downloading the files via our website. There is approximately 31 Gb of compressed data in this directory. Via rsync: rsync -avz --progress \ rsync://hgdownload.cse.ucsc.edu/goldenPath/felCat4/multiz6way/ ./ Via FTP: ftp hgdownload.cse.ucsc.edu user name: anonymous password: go to the directory goldenPath/felCat4/multiz6way To download multiple files from the UNIX command line, use the "mget" command. mget ... - or - mget -a (to download all the files in the directory) Use the "prompt" command to toggle the interactive mode if you do not want to be prompted for each file that you download. --------------------------------------------------------------- All the files in this directory are freely usable for any purpose. For data use restrictions regarding the individual genome assemblies, see http://genome.ucsc.edu/goldenPath/credits.html.