This file is from:

    http://hgdownload.cse.ucsc.edu/goldenPath/cavPor3/multiz6way/README.txt

This directory contains compressed multiple alignments of the 
following assemblies to the Guinea pig genome (cavPor3, Feb. 2008):

Assemblies used in these alignments:                               (alignment
                                                                         type)

Guinea pig         Cavia porcellus          Feb. 2008 (Broad/cavPor3) reference
Malayan flying lemur -
             Galeopterus variegatus   Jun. 2014 (WashU 3.0.2/galVar1) syntenic

Mouse -            Mus musculus             Dec. 2011 (GRCm38/mm10) syntenic
Human -            Homo sapiens             Dec. 2013 (GRCh38/hg38) syntenic
Tree shrew -       Tupaia belangeri    Dec. 2006 (Broad/tupBel1) reciprocal best
Chinese tree shrew - Tupaia chinensis   Jan. 2013 (TupChi_1.0/tupChi1) syntenic

These alignments were prepared using the methods described in the
track description file:
http://genome.ucsc.edu/cgi-bin/hgTrackUi?db=cavPor3&g=cons6way
based on the phylogenetic tree: cavPor3.6way.nh.

Files in this directory:
  - cavPor3.6way.nh - phylogenetic tree used during the multiz
                      multiple alignment
  - cavPor3.6way.commonNames.nh - same as cavPor3.6way.nh with the UCSC database
	names replaced by the common name for the species
  - cavPor3.6way.scientificName.nh - same as cavPor3.6way.nh with the UCSC
	database names replaced by the scientific name for the species
  - upstream*.ensGene..maf.gz - alignments of regions upstream of Ensembl genes
  - cavPor3.6way.maf.gz - the multiple alignments on the Guinea pig genome
  - md5sum.txt - md5 check sums of these files to verify correct download files

The "alignments" directory contains compressed FASTA alignments
for the CDS regions for the gene track ensGene (version 81/Dec 2017)
 of the Guinea pig genome (cavPor3, Feb. 2008) aligned to the assemblies.

The cavPor3.6way.maf.gz file contain all the alignments for the chromosomes
in the Guinea pig genome, including additional annotations to indicate gap
context and genomic breaks for the sequence in the underlying
genome assemblies.  Note, the compressed data size of the
maf file is 3.0 Gb, uncompressed is more than 13 Gb.

The .upstream*.*.maf.gz files contain alignments in regions upstream of
annotated transcription starts for version 91/Dec 2017  Ensembl genes.
with annotated 5' UTRs.  These files differ from the standard
MAF format: they display
alignments that extend from start to end of the upstream region in 
Guinea pig whether or not alignments actually exist. In situations where no  
alignments exist or the alignments of one or more species are missing, 
dot (".") is used as a placeholder. Multiple regions of an assembly's
sequence may align to a single region in Guinea pig therefore, only the 
species name is displayed in the alignment data and no position information 
is recorded. The alignment score is always zero in these files.

For a description of multiple alignment format (MAF), see
http://genome.ucsc.edu/goldenPath/help/maf.html.

PhastCons conservation scores for these alignments are available at:
http://hgdownload.cse.ucsc.edu/goldenPath/cavPor3/phastCons6way

PhyloP conservation scores for these alignments are available at:
http://hgdownload.cse.ucsc.edu/goldenPath/cavPor3/phyloP6way

---------------------------------------------------------------
To download a large file or multiple files from this directory, we recommend 
that you use rsync or ftp rather than downloading the files via our website.
There is approximately 240 Mb of compressed data in this directory.

Via rsync:
rsync -av --progress \
	rsync://hgdownload.cse.ucsc.edu/goldenPath/cavPor3/multiz6way/ ./

Via FTP:
    ftp hgdownload.cse.ucsc.edu 
    user name: anonymous
    password: <your email address>
    go to the directory goldenPath/cavPor3/multiz6way

To download multiple files from the UNIX command line, use the "mget" command. 
    mget <filename1> <filename2> ...
    - or -
    mget -a (to download all the files in the directory) 
Use the "prompt" command to toggle the interactive mode if you do not want 
to be prompted for each file that you download.

---------------------------------------------------------------
All the files in this directory are freely usable for any 
purpose. For data use restrictions regarding the individual 
genome assemblies, see http://genome.ucsc.edu/goldenPath/credits.html.