Description

The Superfamily track shows proteins having homologs with known structures or functions.

Each entry on the track shows the coding region of a gene (based on Ensembl gene predictions). In full display mode, the label for an entry consists of the names of all known protein domains encoded by this gene. This usually contains structural and/or functional descriptions that provide valuable information to help users get a quick grasp of the biological significance of the gene.

Methods

Data are downloaded from the Superfamily server. Using the cross-reference between Superfamily entries and Ensembl gene prediction entries and their alignment to the appropriate genome, the associated data are processed to generate a simple BED format track.

Credits

Superfamily was developed by Julian Gough at the MRC Laboratory of Molecular Biology, Cambridge.

Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure". J. Mol. Biol., 313(4), 903-919.