Gene interactions and pathways from curated databases and text-mining
PIK3CA: top 25 interacting genes (chr3:178866144-178957881)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only PIK3CA-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with PIK3CA, not among the Top 25
Other genes interacting with PIK3CA. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

EGF ▸ RAC1 ▸ EGFR ▸ IL6 ▸ NOS3 ▸ TNF ▸ MMP9 ▸
LEP ▸ IRS1 ▸ PTGS2 ▸ PI3 ▸ IL8 ▸ HMOX1 ▸ ANXA6 ▸
CASP3 ▸ FOXO3 ▸ IRF6 ▸ CASP9 ▸ CASP1 ▸ CASP4 ▸ CASP8 ▸
CASP2 ▸ CASP16 ▸ BCL2 ▸ CASP7 ▸ CASP6 ▸ CASP14 ▸ CASP12 ▸
CASP10 ▸ BCR ▸ SRC ▸ CASP5 ▸ GSK3B ▸ HIF1A ▸ IL2 ▸
IL12B ▸ JUN ▸ HGF ▸ IL12A ▸ IL10 ▸ NOS2 ▸ FOXO1 ▸
NGF ▸ TLR4 ▸ STAT3 ▸ CD28 ▸ MLST8 ▸ FGF2 ▸ RAC2 ▸
CCND1 ▸ CTNNB1 ▸ KRAS ▸ BDNF ▸ NOX3 ▸ NOX5 ▸ ESR1 ▸
NOX4 ▸ TLR2 ▸ IRS2 ▸ TP53 ▸ RAF1 ▸ PTPN11 ▸ MMP2 ▸
RAC3 ▸ NOX1 ▸ CBFA2T2 ▸ IL1B ▸ CREB3 ▸ MAP2K1 ▸ JAK2 ▸
CREB1 ▸ HRAS ▸ CD79A ▸ CREB5 ▸ RHOA ▸ CDC42 ▸ ARHGEF7 ▸
RPTOR ▸ CRK ▸ CD79B ▸ PRKAB2 ▸ IGF2 ▸ PRKAG2 ▸ CDKN1A ▸
PRKAA2 ▸ PRKAA1 ▸ GRAP2 ▸ PRKAG1 ▸ PRKAB1 ▸ PRKACB ▸ MMP14 ▸
CBL ▸ PRKAR2A ▸ HSPG2 ▸ PRKAR1B ▸ PRKAR2B ▸ MCL1 ▸ IFI27 ▸
BMP2 ▸ PRKAR1A ▸ GAB1 ▸ PRKACG ▸ PARP1 ▸ FAS ▸ RAD50 ▸
IFNG ▸ BCL10 ▸ SLC2A4 ▸ SMAD2 ▸ PDGFB ▸ SETD2 ▸ STAT1 ▸
FOS ▸ PLCG1 ▸ SLC25A16 ▸ TLR5 ▸ PIK3R1 ▸ XRCC5 ▸ TMED7 ▸
TCF23 ▸ POT1 ▸ TINF2 ▸ TCF3 ▸ TCF24 ▸ MMP10 ▸ TCF12 ▸
PIK3CD ▸ ANGPT2 ▸ XRCC6 ▸ PDGFRB ▸ CXCL12 ▸ ESR2 ▸ PTK2 ▸
AHSA1 ▸ PIK3CB ▸ TERF1 ▸ PRKCA ▸ TCF15 ▸ BAX ▸ MRE11A ▸
TCF7 ▸ RPS6KB1 ▸ JAK1 ▸ TERF2 ▸ XIAP ▸ TCF4 ▸ MMP7 ▸
IGF1R ▸ TERF2IP ▸ IL4 ▸ TCF20 ▸ TCF19 ▸ TCF25 ▸ PHKA2 ▸
TCF21 ▸ ACD ▸ TLR3 ▸ SYK ▸ IL3 ▸ IL17A ▸ MMP12 ▸
TGFB1 ▸ MMP13 ▸ MYLIP ▸ MMP3 ▸ SP1 ▸ MMP8 ▸ PLD2 ▸
MMP20 ▸ MMP16 ▸ MMP26 ▸ FOXO6 ▸ GJA1 ▸ ILK ▸ MMP17 ▸
MMP11 ▸ TLR8 ▸ PLAU ▸ SREBF1 ▸ TLR1 ▸ PRL ▸ TLR10 ▸
ZGLP1 ▸ SLC2A1 ▸ TLR7 ▸ EIF4EBP1 ▸ MMP28 ▸ FOXO4 ▸ MMP1 ▸
MMP19 ▸ MYD88 ▸ CTGF ▸ MMP27 ▸ JAK3 ▸ VCAM1 ▸ MMP21 ▸
MMP15 ▸ ICAM1 ▸ MMP24 ▸ MMP25 ▸ IKBKG ▸ RAB5A ▸ NOS1 ▸
TLR6 ▸ TLR9 ▸ ECM2 ▸ SMAD5 ▸ SYT1 ▸ HSP90AA1 ▸ STK4 ▸
ECM1 ▸ INSR ▸ FOSL1 ▸ FYN ▸ NTRK1 ▸ CXCL11 ▸ HRG ▸
STK16 ▸ BCL9 ▸ IL13 ▸ PLCG2 ▸ GYS2 ▸ SMAD1 ▸ STK11 ▸
GRB2 ▸ STK19 ▸ PTK6 ▸ STK31 ▸ STK39 ▸ KITLG ▸ GDNF ▸
BCL6 ▸ GYS1 ▸ STK33 ▸ MET ▸ CSF1 ▸ STK10 ▸ LCK ▸
SERPINE1 ▸ PIP ▸ STK3 ▸ CA2 ▸ PDLIM7 ▸ PTK7 ▸ STK38 ▸
IL7 ▸ PLA2G1B ▸ RICTOR ▸ STK35 ▸ BCL3 ▸ BTK ▸ WNK1 ▸
LPA ▸ SLC22A3 ▸ EPO ▸ STK40 ▸ NFKBIA ▸ SMAD4 ▸ BCL5 ▸
CDH1 ▸ IL18 ▸ STK36 ▸ TGFB2 ▸ STK25 ▸ FGF21 ▸ STK24 ▸
PAK1 ▸ BPNT1 ▸ CAV2 ▸ PLA2G4A ▸ PPP1R3A ▸ FGF23 ▸ IL32 ▸
SMAD7 ▸ ADORA3 ▸ PDE3B ▸ IL11 ▸ NPY4R ▸ ODC1 ▸ PCNA ▸
TNFSF10 ▸ RNF19A ▸ TAT ▸ SMAD3 ▸ GAB2 ▸ FGF17 ▸ FGF9 ▸
RBBP7 ▸ TNFSF13B ▸ ADORA1 ▸ CALM3 ▸ PDK1 ▸ PLD5 ▸ NANOG ▸
FGF3 ▸ CXCL9 ▸ EHMT1 ▸ ABCB1 ▸ PPARG ▸ WNT4 ▸ SPP1 ▸
CCNG1 ▸ CAT ▸ SOAT1 ▸ PIK3CG ▸ AR ▸ FGF4 ▸ FGF7 ▸
LGALS3 ▸ CAV3 ▸ KIT ▸ BMP6 ▸ IL5 ▸ SMAD6 ▸ PLD6 ▸
SGK1 ▸ PLD3 ▸ FGF11 ▸ MYC ▸ TPO ▸ ITGB1 ▸ SMAD9 ▸
FGF19 ▸ IL1A ▸ AKT1S1 ▸ HDAC2 ▸ RLN1 ▸ FGF14 ▸ RUNX2 ▸
PAK2 ▸ HDAC1 ▸ CD4 ▸ HSPB1 ▸ CCND2 ▸ PBK ▸ CYP19A1 ▸
SHC1 ▸ BAD ▸ FGF12 ▸ PLD1 ▸ FASLG ▸ GSK3A ▸ FGF5 ▸
RLN2 ▸ IL24 ▸ CTLA4 ▸ NTRK2 ▸ SGK3 ▸ RLN3 ▸ VAV1 ▸
FGF16 ▸ FGF20 ▸ CXCR4 ▸ FGF22 ▸ NA ▸ CDC73 ▸ RBBP4 ▸
EGR1 ▸ BRAF ▸ PIK3IP1 ▸ CAV1 ▸ HDAC3 ▸ FGF18 ▸ F2RL1 ▸
FGF1 ▸ STAT6 ▸ ERBB2 ▸ FGF10 ▸ FGF6 ▸ GPR15 ▸ ATP5O ▸
FGF8 ▸ PLD4 ▸ FGF13 ▸ ABL1 ▸ GPR146 ▸ GPR84 ▸ GPR88 ▸
RHEB ▸ GPR128 ▸ BMP4 ▸ GPR160 ▸ ITGB4 ▸ ITGA5 ▸ DAB2IP ▸
ADAM12 ▸ IL15 ▸ C1orf228 ▸ GPR171 ▸ CDC26 ▸ BMP3 ▸ HBEGF ▸
MOK ▸ GPR87 ▸ CDC23 ▸ WNT2 ▸ PLEK ▸ IL33 ▸ BMP1 ▸
CDC34 ▸ GPR31 ▸ ANG ▸ CD38 ▸ IL22 ▸ RPL17 ▸ GPR26 ▸
NCF4 ▸ CDC40 ▸ GPR107 ▸ GPR98 ▸ GPR133 ▸ GPR22 ▸ ARSK ▸
GPR151 ▸ LDLR ▸ SOCS3 ▸ LYN ▸ CD14 ▸ NRG1 ▸ NFE2L2 ▸
MAP3K7 ▸ CDC6 ▸ GPR65 ▸ GPR139 ▸ GPR182 ▸ IGFBP3 ▸ BMP7 ▸
PKD3 ▸ IL26 ▸ BIRC2 ▸ GPR141 ▸ TFRC ▸ GPS2 ▸ SNAI2 ▸
GPR157 ▸ CDH5 ▸ SKP2 ▸ IL20 ▸ GPR183 ▸ MUC8 ▸ DAB1 ▸
GRP ▸ TYR ▸ WNT16 ▸ IL1RN ▸ GPR52 ▸ BRCA1 ▸ CXCL10 ▸
GPR37 ▸ IL27 ▸ GPR34 ▸ GPR4 ▸ PDX1 ▸ TGFB3 ▸ GPR156 ▸
PAK4 ▸ CDC20 ▸ CDC45 ▸ MYOG ▸ AQP3 ▸ WNT11 ▸ GPR176 ▸
MAP3K5 ▸ CHKA ▸ GPR174 ▸ PTH ▸ GPR144 ▸ GPR115 ▸ GPR85 ▸
BSG ▸ GPR79 ▸ GPR63 ▸ RBL2 ▸ IL31 ▸ GPR126 ▸ NCF1 ▸
NTRK3 ▸ CHUK ▸ CSE ▸ GPR124 ▸ RAE1 ▸ GPR35 ▸ ARAF ▸
GPR56 ▸ GPR20 ▸ GPR125 ▸ PAK6 ▸ IL34 ▸ CSF2 ▸ GPR161 ▸
GPR162 ▸ ITGA6 ▸ GAPDH ▸ ADRBK1 ▸ GPR101 ▸ SLC9A1 ▸ GPR132 ▸
GPR68 ▸ IL25 ▸ MSC ▸ GPR114 ▸ VEGFC ▸ CX3CL1 ▸ CALM1 ▸
PLAT ▸ AGTR2 ▸ GDF15 ▸ HMGB1 ▸ GPR12 ▸ GPR119 ▸ GPR25 ▸
GPR153 ▸ GPR137 ▸ NFAT5 ▸ GPR45 ▸ IL19 ▸ GPR149 ▸ GPR21 ▸
GPR152 ▸ CDC27 ▸ GPR143 ▸ PTTG1 ▸ CCK ▸ GPR155 ▸ PGP ▸
IL37 ▸ GPR1 ▸ SST ▸ GPR32 ▸ GPR173 ▸ ICOS ▸ IRF1 ▸
GPR27 ▸ GPR110 ▸ CD19 ▸ FGR ▸ GPR75 ▸ IL9 ▸ MYCN ▸
SLPI ▸ NOTCH1 ▸ GPR142 ▸ NTF3 ▸ E2F1 ▸ SIRT1 ▸ CCDC88A ▸
GPR82 ▸ TBL1XR1 ▸ CDC7 ▸ GPR135 ▸ PRDX2 ▸ IKBKB ▸ CORO2A ▸
ERBB4 ▸ GPR61 ▸ GPR39 ▸ NM ▸ GPR116 ▸ GPR148 ▸ GPR33 ▸
GPR108 ▸ IL6ST ▸ GPR17 ▸ GTPBP1 ▸ CDC123 ▸ GPR6 ▸ TBL1X ▸
GPR180 ▸ TRNAE1 ▸ NCOR1 ▸ CEBPA ▸ GPR36 ▸ GPR111 ▸ GPR158 ▸
CCL2 ▸ CDC37 ▸ CD2 ▸ CDK5 ▸ MDM2 ▸ SMN1 ▸ GNE ▸
GPR18 ▸ GPER1 ▸ PAK7 ▸ IL21 ▸ CEBPB ▸ BMP15 ▸ GPR83 ▸
LIF ▸ GPR113 ▸ GPR112 ▸ IL16 ▸ MUC1 ▸ MT3 ▸ ITIH4 ▸
PSEN1 ▸ CALM2 ▸ FOXP3 ▸ PKD1 ▸ GPR42 ▸ GPR97 ▸ GPR78 ▸
PKD2 ▸ PAK3 ▸ TSC2 ▸ IRS4 ▸ CPOX ▸ GPR19 ▸ BMP10 ▸
GPR179 ▸ UCN ▸ WNT3 ▸ WNT6 ▸ LTB ▸ GPR55 ▸ CDC16 ▸
GPR150 ▸ GPR3 ▸ GPR50 ▸ UVRAG ▸ PREX1 ▸ PRKCZ ▸ PTGES ▸
DDIT3 ▸ CD86 ▸ GPR123 ▸ WNT1 ▸ IFNB1 ▸ GPR62 ▸ BMP5 ▸
GPR64 ▸ FGFR2 ▸ PHLDA1 ▸ SLC25A3 ▸ PIK3R4 ▸ HRNR ▸ F11R ▸
HIST1H2BB ▸ SLC9A3R1 ▸ HIST2H2BF ▸ ZAP70 ▸ IGLC3 ▸ CCT5 ▸ EIF2AK1 ▸
MRPL12 ▸ YBX3 ▸ BASP1 ▸ CPSF1 ▸ DNAJA1 ▸ GNG7 ▸ CD3Z ▸
GNA15 ▸ GFRA1 ▸ PABPC4 ▸ FLNB ▸ YWHAG ▸ MRPS25 ▸ B2M ▸
PIK3R6 ▸ EIF5A ▸ FGFR1OP2 ▸ PTCD3 ▸ RUVBL1 ▸ YWHAZ ▸ MYH10 ▸
LAT ▸ ITK ▸ FCGR3A ▸ PCBP2 ▸ TXK ▸ SLC25A4 ▸ RTCB ▸
IL1R1 ▸ HIST1H2BN ▸ CRKL ▸ UFD1L ▸ RPS5 ▸ HNRNPA1 ▸ GNB4 ▸
HNRNPH1 ▸ NEDD9 ▸ SYNCRIP ▸ MRAS ▸ TRB@ ▸ GNB3 ▸ GNGT1 ▸
RASD2 ▸ PDPK1 ▸ HNRNPH3 ▸ OCRL ▸ H2AFJ ▸ GH1 ▸ RPLP1 ▸
EPS8 ▸ HIST3H2BB ▸ ERH ▸ GHR ▸ PPP1CC ▸ IL23A ▸ IGHG4 ▸
GNAQ ▸ IL2RG ▸ MIF ▸ DNM1L ▸ PABPC1 ▸ ACTA2 ▸ GNG2 ▸
CANX ▸ PIP5K1B ▸ HLA-B ▸ HNRNPF ▸ KIRREL ▸ FCER1G ▸ MS4A2 ▸
NGFB ▸ NKRF ▸ ALDOA ▸ EPHB1 ▸ IGF2BP2 ▸ MRPS26 ▸ NR3C1 ▸
PABPN1 ▸ MRPS34 ▸ HIST2H2AC ▸ FTL ▸ PIK3R5 ▸ AP1M2 ▸ INS-IGF2 ▸
XRN2 ▸ NPHS2 ▸ HIST1H2AE ▸ PCBP3 ▸ PIP5K1A ▸ HLA-A ▸ MRPS23 ▸
NEFH ▸ PCBP1 ▸ SHANK3 ▸ IL2RB ▸ PLCD4 ▸ GNAI1 ▸ ARHGEF1 ▸
PDGFRA ▸ RPL28 ▸ GNAO1 ▸ PRKCI ▸ MRPS22 ▸ RPSA ▸ MARCKS ▸
DHX30 ▸ SGK2 ▸ EIF5A2 ▸ PLCD3 ▸ IGHE ▸ FGFR1OP ▸ MATR3 ▸
GNB5 ▸ PRKRA ▸ PGR ▸ SYNJ1 ▸ ZMYM2 ▸ MAP2K2 ▸ MYO1C ▸
IGLC1 ▸ PIK3C2G ▸ PIP4K2A ▸ NPM1 ▸ HIST1H2BL ▸ PIK3R2 ▸ PLCE1 ▸
KLRD1 ▸ Il7r ▸ ATXN2L ▸ GNA11 ▸ FIGF ▸ ATP5B ▸ HIST1H2AH ▸
TUBA1C ▸ FCGR3B ▸ ABI1 ▸ HIST1H2AD ▸ GRIN2B ▸ JUP ▸ RPLP0 ▸
EFNA1 ▸ AMBP ▸ ILF2 ▸ VARS2 ▸ HSP90AB1 ▸ GNG13 ▸ ITGAV ▸
RPLP0P6 ▸ RPL23 ▸ RPS10 ▸ HNRNPUL1 ▸ PON2 ▸ YWHAH ▸ MRPS17 ▸
ATPIF1 ▸ SLC25A5 ▸ VEGF ▸ APPL1 ▸ CSF2RB ▸ PIP5K1C ▸ FES ▸
IGHG1 ▸ UBC ▸ MRPS28 ▸ RBMX ▸ WDR5 ▸ HIST3H2A ▸ KLB ▸
KLRK1 ▸ ACTG2 ▸ GNB1 ▸ RPS4X ▸ RPS20 ▸ PIK3R3 ▸ CSF2RA ▸
HLA-E ▸ SH2D2A ▸ PGAM4 ▸ SMO ▸ RALY ▸ IL4R ▸ CBLC ▸
HIST1H2BO ▸ PPP1CB ▸ SLC25A31 ▸ HNRNPDL ▸ YES1 ▸ AMPH ▸ MRPS14 ▸
RPS12 ▸ SEMG1 ▸ CALR ▸ DNAJB6 ▸ RUVBL2 ▸ SHC3 ▸ IGKV1-5 ▸
HIST1H4A ▸ HIST1H2BK ▸ HNRNPR ▸ PPP1CA ▸ DDX17 ▸ IGLC2 ▸ HIST1H2AC ▸
RHOG ▸ IL1RAP ▸ GNG11 ▸ INSRR ▸ CD247 ▸ APLP2 ▸ TIAM2 ▸
FLT3 ▸ TIMM50 ▸ HLA-DRA ▸ GNG5 ▸ EIF5AL1 ▸ PTBP1 ▸ MYH14 ▸
HIST1H2BJ ▸ TUBA4A ▸ PGAM2 ▸ IGF2BP1 ▸ HIST2H2AA3 ▸ CTNNA1 ▸ FGB ▸
MDH2 ▸ HIST1H1T ▸ DDX3Y ▸ TUBB4B ▸ HNRNPD ▸ GNG12 ▸ FGA ▸
IL23R ▸ HNRNPA0 ▸ EEF2 ▸ PCID2 ▸ PGF ▸ EEF1A1 ▸ HIST1H2AB ▸
UPF1 ▸ ALYREF ▸ GNB2 ▸ HIST1H2BD ▸ ADAP1 ▸ WDR6 ▸ INPP5E ▸
RRAS2 ▸ MYH9 ▸ PLCB3 ▸ PLCD1 ▸ PGAM1 ▸ ATP1A1 ▸ VLDLR ▸
ELAVL1 ▸ PLCB2 ▸ LRPPRC ▸ EEF1A2 ▸ RPS24 ▸ HNRNPK ▸ MASP1 ▸
KHDRBS1 ▸ ITIH1 ▸ PLCB1 ▸ EDG1 ▸ MYL6 ▸ STAT5B ▸ STAU1 ▸
IL12RB1 ▸ FRS2 ▸ LAT2 ▸ ACTBL2 ▸ CKB ▸ EEF1A1P5 ▸ DDX5 ▸
YWHAQ ▸ TREM2 ▸ IL3RA ▸ HIST2H2BE ▸ NRAS ▸ ADAR ▸ SPTA1 ▸
SOS1 ▸ SSR1 ▸ MRPS18B ▸ PLCB4 ▸ IGHG3 ▸ UNC5B ▸ TRAT1 ▸
NPHS1 ▸ HIST1H2AJ ▸ PIK3C2A ▸ TEK ▸ SYNJ2 ▸ TPI1 ▸ MOV10 ▸
SHC2 ▸ HNRNPAB ▸ H2BFS ▸ PPIA ▸ POTEKP ▸ IGKV4-1 ▸ ANGPT1 ▸
GNG10 ▸ HIST1H2BM ▸ KLRC2 ▸ HIST2H2AA4 ▸ GSN ▸ GNA14 ▸ PTPN1 ▸
IL5RA ▸ PDE4D ▸ ANXA2 ▸ RPS11 ▸ VAV2 ▸ TUBB ▸ HNRNPA2B1 ▸
ATR ▸ UBTF ▸ CSF1R ▸ RPS2 ▸ HCST ▸ HNRNPL ▸ FCGR1A ▸
HIST1H2AG ▸ TRIM24 ▸ HIST1H1A ▸ PGK1 ▸ PAICS ▸ GABRB1 ▸ EPHB4 ▸
SNRPF ▸ HNRNPU ▸ SNRPD3 ▸ HNRNPC ▸ NBPF8 ▸ BCAR1 ▸ RPS3 ▸
IGLC7 ▸ IGKC ▸ GNGT2 ▸ DDX3X ▸ FBL ▸ PIK3C2B ▸ CD80 ▸
HNRNPH2 ▸ PTMA ▸ ENY2 ▸ PIK3AP1 ▸ DHX9 ▸ RASGRP3 ▸ TYROBP ▸
FLT1 ▸ DGKZ ▸ PLCZ1 ▸ FCER1A ▸ GNAI3 ▸ CNTRL ▸ HIST1H2BH ▸
MRPS27 ▸ ATP1A3 ▸ CBLB ▸ RPL22 ▸ AIFM1 ▸ GNG8 ▸ VAV3 ▸
ITGB3 ▸ PRDX6 ▸ GNG3 ▸ LDHB ▸ TRIM21 ▸ S100A10 ▸ EFNB2 ▸
FGG ▸ IGF2BP3 ▸ HLA-DRB1 ▸ ILF3 ▸ SEMG2 ▸ IGLC6 ▸ KL ▸
FUS ▸ PIP4K2C ▸ IGHG2 ▸ EPB41L1 ▸ GNAI2 ▸ YWHAE ▸ SQSTM1 ▸
C14orf166 ▸ LGALS3BP ▸ DNAJB11 ▸ RPS18 ▸ DLG1 ▸ IFNGR1 ▸ TUBA1A ▸
SH3KBP1 ▸ ENO1 ▸ ITGB2 ▸ HNRNPA3 ▸ INPP5B ▸ CCAR2 ▸ DHX15 ▸
GNG4 ▸ CUX1 ▸ TRA@ ▸
Data information
Please see the Gene Interactions Track Manual.