Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766818-22771617)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ VEGFA ▸ IL5 ▸ IL18 ▸ IL21 ▸
TLR3 ▸ ICAM1 ▸ IL33 ▸ PTGS2 ▸ IL22 ▸ IL7 ▸ TLR9 ▸
FGB ▸ CD40 ▸ IL32 ▸ CCL2 ▸ IL11 ▸ INS ▸ IL15 ▸
IL19 ▸ IL31 ▸ IL24 ▸ JAK2 ▸ IL26 ▸ IL16 ▸ IL9 ▸
IL20 ▸ IL25 ▸ IL34 ▸ JUN ▸ IL6ST ▸ IL37 ▸ IL27 ▸
NOS2 ▸ SOCS3 ▸ TLR7 ▸ TLR5 ▸ TLR1 ▸ STAT1 ▸ TLR8 ▸
TLR6 ▸ TLR10 ▸ PTH ▸ IL12B ▸ SOAT1 ▸ SAA1 ▸ IL1RN ▸
CSRP1 ▸ JAK1 ▸ AKT1 ▸ FOS ▸ AKT2 ▸ AKT3 ▸ CD79A ▸
LEP ▸ IL12A ▸ LRPPRC ▸ PIK3CA ▸ VIP ▸ PIK3R1 ▸ RNF19A ▸
LTA ▸ CRK ▸ CD40LG ▸ ADCYAP1 ▸ LEO1 ▸ MMP1 ▸ CTR9 ▸
PTX3 ▸ PAF1 ▸ CDC73 ▸ WDR61 ▸ LIF ▸ PRKAA1 ▸ PRKAG1 ▸
PRKAA2 ▸ FGF2 ▸ PRKAG2 ▸ PRKAB2 ▸ IL6R ▸ PRKAB1 ▸ GP9 ▸
HGF ▸ PTX4 ▸ GP2 ▸ GP5 ▸ GP6 ▸ MMP3 ▸ IGF1 ▸
MMP9 ▸ EDN1 ▸ MYLIP ▸ GRAP2 ▸ CRH ▸ JAK3 ▸ TCF3 ▸
MMP2 ▸ TCF15 ▸ TCF20 ▸ TCF12 ▸ TCF25 ▸ TCF7 ▸ TCF4 ▸
MYD88 ▸ TCF19 ▸ TCF21 ▸ TCF24 ▸ CD4 ▸ CISH ▸ TCF23 ▸
CA2 ▸ MMP13 ▸ IFNB1 ▸ TGFB3 ▸ NOS3 ▸ PLG ▸ A2M ▸
MCL1 ▸ TGFB2 ▸ PAM ▸ AHSA1 ▸ TIMP1 ▸ OSM ▸ NOS1 ▸
CD14 ▸ HP ▸ HNRNPF ▸ HMGB1 ▸ PGF ▸ PTBP2 ▸ CD46 ▸
CEBPB ▸ PTBP1 ▸ HNRNPH1 ▸ NFKBIA ▸ STAT5A ▸ CSF1 ▸ APOB ▸
MT3 ▸ NA ▸ AR ▸ NOX4 ▸ CASP3 ▸ ALB ▸ S100A12 ▸
PRG2 ▸ PRG3 ▸ TAT ▸ TNFSF11 ▸ PI3 ▸ PRG4 ▸ PRKAR1A ▸
NGF ▸ NOX1 ▸ CASP16 ▸ PRKACG ▸ NOX5 ▸ CASP2 ▸ CASP14 ▸
CASP1 ▸ CASP6 ▸ PRKACB ▸ CASP7 ▸ CSF3 ▸ PRKAR2B ▸ CASP8 ▸
CASP4 ▸ PRKAR1B ▸ CASP5 ▸ CASP12 ▸ NOX3 ▸ CASP9 ▸ CASP10 ▸
PRKAR2A ▸ FOXP3 ▸ POLDIP2 ▸ ANGPT2 ▸ VCAM1 ▸ FAS ▸ MT4 ▸
PRL ▸ LPA ▸ PDGFB ▸ ITIH4 ▸ GPI ▸ SOCS1 ▸ SELE ▸
MMP11 ▸ SPP1 ▸ SAA2 ▸ SYT1 ▸ CD8A ▸ SOD3 ▸ CYP19A1 ▸
CALM3 ▸ MMP10 ▸ MMP14 ▸ SOD1 ▸ FASLG ▸ MMP7 ▸ IKBKB ▸
LBP ▸ SOD2 ▸ CEBPA ▸ MMP8 ▸ HMOX1 ▸ BCL2 ▸ PTPN11 ▸
ANG ▸ PLA2G1B ▸ APP ▸ IFI44 ▸ IRF1 ▸ NUP43 ▸ MMP12 ▸
TNFRSF11B ▸ CPOX ▸ CTSB ▸ SETBP1 ▸ SERPINE1 ▸ MMP28 ▸ CALML3 ▸
MMP15 ▸ MMP21 ▸ ADIPOQ ▸ MMP16 ▸ MMP17 ▸ MMP20 ▸ EGF ▸
LPL ▸ MMP24 ▸ NAALADL1 ▸ F2RL1 ▸ HDAC1 ▸ CCL3 ▸ ALG1 ▸
MMP25 ▸ MMP26 ▸ MMP19 ▸ FCER2 ▸ MMP27 ▸ CD28 ▸ APC ▸
PRDX2 ▸ PTHLH ▸ AGT ▸ PTPRC ▸ IL23A ▸ MIF ▸ BCL6 ▸
HES1 ▸ GFAP ▸ MAP3K7 ▸ FGF1 ▸ BCL3 ▸ IRAK4 ▸ HDAC2 ▸
CSK ▸ ERVK-6 ▸ FGF4 ▸ NPS ▸ MSH6 ▸ SERPINA3 ▸ LTF ▸
FGF23 ▸ MSH3 ▸ FGF7 ▸ TYR ▸ PLA2G4A ▸ GH1 ▸ SAA4 ▸
PPARG ▸ AGTR2 ▸ ABCC1 ▸ FGF20 ▸ FGF14 ▸ FGF9 ▸ FGF6 ▸
CUL1 ▸ MTX1 ▸ TP53 ▸ F2R ▸ PPARA ▸ SKP1 ▸ FGF22 ▸
FGF3 ▸ CREB3 ▸ FGF16 ▸ FGF19 ▸ IFNA2 ▸ FGF11 ▸ PDLIM7 ▸
LTB ▸ SMAD3 ▸ FGF8 ▸ CHUK ▸ IL1R1 ▸ FGF12 ▸ MSH2 ▸
FGF18 ▸ FGF5 ▸ FGF21 ▸ IGF2 ▸ CREB1 ▸ FGF10 ▸ CREB5 ▸
FGF17 ▸ MSH4 ▸ MSH5 ▸ KITLG ▸ FGF13 ▸ IL2RA ▸ CEACAM5 ▸
CEBPD ▸ BMP2 ▸ CCL5 ▸ IFNA14 ▸ PTK7 ▸ HES3 ▸ HES2 ▸
SMAD2 ▸ MTOR ▸ ANXA1 ▸ MPO ▸ HES7 ▸ CXCL12 ▸ IFNA13 ▸
EGFR ▸ SST ▸ TRAF6 ▸ ESR1 ▸ HSPD1 ▸ IFNA7 ▸ IFNA4 ▸
IFNA1 ▸ HES6 ▸ HES4 ▸ CD44 ▸ IFNA6 ▸ MAP2K1 ▸ IFNA17 ▸
IFNA5 ▸ EPO ▸ MRXS5 ▸ RHO ▸ TXN ▸ PTK6 ▸ CD8B ▸
UCN ▸ IFNA10 ▸ IFNA16 ▸ PTK2 ▸ HES5 ▸ CDKN1A ▸ IFNA21 ▸
IFNA8 ▸ TFPI ▸ SP1 ▸ PAEP ▸ CXCL10 ▸ CAV3 ▸ CAV2 ▸
HAMP ▸ MAP2K4 ▸ SMAD4 ▸ CNTN2 ▸ IKBKG ▸ STAT4 ▸ HSPB1 ▸
FCGR1A ▸ ANPEP ▸ CAV1 ▸ NAMPT ▸ AVP ▸ SMAD7 ▸ BAX ▸
IDO1 ▸ WNK1 ▸ CNTF ▸ MUC1 ▸ RENBP ▸ NPY ▸ CXCL1 ▸
RBBP4 ▸ C4BPA ▸ PRKCA ▸ KLK3 ▸ RBBP7 ▸ P2RX7 ▸ SAP130 ▸
TGFA ▸ GCG ▸ SMAD1 ▸ ACE ▸ BMP6 ▸ GZMB ▸ TNFRSF1B ▸
ADM ▸ DDIT3 ▸ RAG2 ▸ SRC ▸ ADCY8 ▸ CSE ▸ NOD1 ▸
CD86 ▸ SMAD6 ▸ SUDS3 ▸ IRS1 ▸ CCR5 ▸ SMAD5 ▸ BCL10 ▸
SIN3A ▸ HLA-DRB1 ▸ AGTR1 ▸ CHAT ▸ S100B ▸ CORT ▸ ACP2 ▸
IRF3 ▸ SHC1 ▸ ADCY6 ▸ MET ▸ STS ▸ CLEC7A ▸ CYP3A4 ▸
ADCY5 ▸ ARID4B ▸ GIF ▸ JUND ▸ HLA-DRA ▸ ADCY4 ▸ ADCY1 ▸
ADCY7 ▸ CAT ▸ NPPA ▸ ADCY9 ▸ PDCD11 ▸ SAP30 ▸ SYK ▸
CD5 ▸ SELL ▸ MUC4 ▸ IRAK1 ▸ IFI27 ▸ NOD2 ▸ ADCY10 ▸
TAB1 ▸ ADCY2 ▸ RAG1 ▸ HIF1A ▸ BMP7 ▸ MBP ▸ WNT5A ▸
HDC ▸ NPEPPS ▸ TNFRSF1A ▸ ADCY3 ▸ REL ▸ DUSP1 ▸ IL17RA ▸
SMAD9 ▸ SELP ▸ NM ▸ MAP2K5 ▸ IBD7 ▸ TNFSF13B ▸ TPO ▸
IBD2 ▸ MUC19 ▸ CYP1A1 ▸ OPRM1 ▸ IL17D ▸ IBD5 ▸ ICOSLG ▸
IRAK3 ▸ IBD3 ▸ MOG ▸ HSP90AB1 ▸ MUC22 ▸ SETD2 ▸ PGP ▸
CR2 ▸ UTP3 ▸ LGALS1 ▸ CTGF ▸ HSPG2 ▸ ARSA ▸ IBD8 ▸
PTGS1 ▸ MUC17 ▸ MUC2 ▸ IBD4 ▸ UTP6 ▸ MAP2K6 ▸ HSF1 ▸
ICAM4 ▸ MAP2K3 ▸ MUC13 ▸ POMC ▸ UTP20 ▸ IL17F ▸ MUC12 ▸
MUC15 ▸ UTP15 ▸ ST2 ▸ CTSL ▸ SFTPC ▸ REG1A ▸ TNFRSF8 ▸
BMP1 ▸ RETN ▸ AHR ▸ UTP18 ▸ IGFBP1 ▸ MAP2K7 ▸ ZFP36 ▸
BCL9 ▸ FGFR3 ▸ CCND1 ▸ PPP2CA ▸ MUC8 ▸ PLD1 ▸ PDGFA ▸
MUC7 ▸ PIGA ▸ ITGB1 ▸ CYP3A ▸ TYK2 ▸ CXCL17 ▸ INA ▸
BCL5 ▸ GRB2 ▸ NCAM1 ▸ PLD2 ▸ ANXA6 ▸ MAP2K2 ▸ APOE ▸
VAV1 ▸ CTF1 ▸ MUC21 ▸ CCL20 ▸ PTPN4 ▸ MUC6 ▸ ATP8A2 ▸
EIF2AK2 ▸ IBD9 ▸ ICAM3 ▸ NLRP3 ▸ ICAM5 ▸ S100A9 ▸ UTP23 ▸
MPG ▸ BTRC ▸ ABCB1 ▸ TF ▸ MUC20 ▸ SEA ▸ EDN2 ▸
ADORA1 ▸ HRAS ▸ ATF3 ▸ MUC16 ▸ HMGCR ▸ S100A8 ▸ IRF4 ▸
EDN3 ▸ IBD6 ▸ ICAM2 ▸ UCN2 ▸ HCL1 ▸ SCARB1 ▸ TRAF2 ▸
PLD5 ▸ TRNAI1 ▸ TEC ▸ PPP2R1A ▸ SLPI ▸ TSLP ▸ HSP90AA1 ▸
HCL3 ▸ GAL ▸ CHGA ▸ IGFBP3 ▸ BMP4 ▸ PARP1 ▸ GPX6 ▸
GNRH1 ▸ PARK2 ▸ TIMP2 ▸ DNMT1 ▸ HDAC6 ▸ SERPINF1 ▸ NEUROD2 ▸
GPX1 ▸ GNA13 ▸ TNPO1 ▸ CPB1 ▸ NNMT ▸ IL1R2 ▸ CRYGEP ▸
PARP14 ▸ CD163 ▸ TGM2 ▸ ITGAM ▸ FXR1 ▸ ETS2 ▸ GYS1 ▸
THBD ▸ BMP10 ▸ FXR2 ▸ GPX5 ▸ FOXO3 ▸ C1QA ▸ OAS3 ▸
ROR1 ▸ EPS15 ▸ GPX8 ▸ MPL ▸ PTS ▸ HCL2 ▸ LCN2 ▸
PITX2 ▸ PARP15 ▸ CXCL6 ▸ HSPA5 ▸ PDCD4 ▸ PLD3 ▸ PLD6 ▸
BPI ▸ OAS2 ▸ NEUROD4 ▸ PARP6 ▸ C5AR1 ▸ IRF9 ▸ PCK1 ▸
LYN ▸ GHRH ▸ C1QB ▸ HSPB3 ▸ CD1D ▸ NEUROD1 ▸ OPN1LW ▸
OAS1 ▸ RPL17 ▸ PPP2R2B ▸ MS4A1 ▸ GPX4 ▸ MAPKAPK2 ▸ GPX3 ▸
NEUROD6 ▸ ATP5O ▸ EBP ▸ FUT4 ▸ ABL1 ▸ CD2 ▸ KNG1 ▸
NFATC2 ▸ CLU ▸ NTF3 ▸ PARP8 ▸ CD80 ▸ CA1 ▸ IRF8 ▸
BMP5 ▸ FXYD1 ▸ C1orf228 ▸ ACHE ▸ GPX7 ▸ BTK ▸ PARP10 ▸
BMP3 ▸ PARP3 ▸ PARP4 ▸ PARP11 ▸ GPX2 ▸ PARP2 ▸ PARP9 ▸
ETS1 ▸ CXCR4 ▸ GTF2B ▸ EPX ▸ TRPV1 ▸ PARP16 ▸ CYP1A2 ▸
CX3CR1 ▸ AHSG ▸ PON1 ▸ CSH2 ▸ PARP12 ▸ XRCC1 ▸ HDAC3 ▸
BCR ▸ IRF5 ▸ XBP1 ▸ HPD ▸ CTSS ▸ NDP ▸ WNT10B ▸
CPB2 ▸ GYS2 ▸ ATP7A ▸ CCL1 ▸ PLD4 ▸ WNT4 ▸ HCK ▸
BMP15 ▸ CIB1 ▸ BGLAP ▸ ADORA3 ▸ ESR2 ▸ PIM1 ▸ MAF ▸
EPS8 ▸ CD19 ▸ IDS ▸ ANGPT1 ▸ PGD ▸ FLOT2 ▸ ATF4 ▸
HDAC10 ▸ CCR1 ▸ TGM7 ▸ ASIP ▸ IL2RG ▸ CCL4 ▸ NT5E ▸
ITGA5 ▸ PDCD6 ▸ DERL1 ▸ UCN3 ▸ BAI1 ▸ TIMP3 ▸ RASIP1 ▸
COQ2 ▸ WNT6 ▸ GAS6 ▸ STK35 ▸ TRAF3IP2 ▸ CCR2 ▸ IL2RB ▸
SAA3P ▸ SFTPA1 ▸ ADH4 ▸ FGL1 ▸ MCC ▸ CD33 ▸ TAC1 ▸
NTS ▸ SMN1 ▸ PPP5C ▸ SMC3 ▸ TRAF5 ▸ THBS1 ▸ TIRAP ▸
CDKN1B ▸ IRF7 ▸ WNT1 ▸ SP3 ▸ E2F1 ▸ CHP2 ▸ PIAS3 ▸
ECM1 ▸ STEAP4 ▸ TBP ▸ RAC1 ▸ TGM4 ▸ C5 ▸ MIP ▸
CDK4 ▸ NTN1 ▸ COQ3 ▸ ITGA4 ▸ EGR1 ▸ ADH7 ▸ MEPE ▸
SMC5 ▸ APCS ▸ STK40 ▸ TTR ▸ C3AR1 ▸ KRT37 ▸ IGFBP7 ▸
MYC ▸ RORC ▸ HPX ▸ HSPB8 ▸ IRF2 ▸ CD59 ▸ CXCL16 ▸
MTA2 ▸ ARG1 ▸ HCFC1 ▸ STK38 ▸ WNT2 ▸ ITGA2B ▸ ACAN ▸
AREG ▸ IFIT1 ▸ NR4A1 ▸ GIP ▸ SLC25A3 ▸ PLA2G2D ▸ LDLR ▸
JUNB ▸ PINK1 ▸ TSC22D3 ▸ GSTM1 ▸ KRT38 ▸ ADH6 ▸ STK19 ▸
FMR1 ▸ CEBPZ ▸ IGFBP2 ▸ IGFBP5 ▸ KLRB1 ▸ SLC33A1 ▸ RBP4 ▸
KRT10 ▸ TNFSF10 ▸ KRT13 ▸ RNASE3 ▸ VWF ▸ ACD ▸ SCG3 ▸
SOS1 ▸ EEF1A2 ▸ COQ4 ▸ STK11 ▸ CP ▸ RPS6KA3 ▸ DEFB4B ▸
GSTM3 ▸ STK31 ▸ MTA3 ▸ ADIPOR1 ▸ SDC1 ▸ EREG ▸ EDNRA ▸
STK16 ▸ TAC3 ▸ CD34 ▸ CD1C ▸ PSMB9 ▸ STK25 ▸ RLN3 ▸
AMELX ▸ NOTCH1 ▸ SARS ▸ MUC5AC ▸ NOTCH2 ▸ TFAP2A ▸ COL1A1 ▸
HDAC5 ▸ CHP1 ▸ OXTR ▸ PLAT ▸ SMC2 ▸ TRD ▸ SCG5 ▸
TNC ▸ MYO16 ▸ GSTM2 ▸ PTPN22 ▸ SMC4 ▸ STK10 ▸ DYNLRB1 ▸
SMC6 ▸ CXCL11 ▸ CD38 ▸ FLT3LG ▸ ANGPT4 ▸ TRAF1 ▸ COQ9 ▸
HDAC8 ▸ ATF1 ▸ LRG1 ▸ PDCD2 ▸ MCS ▸ RAF1 ▸ CXCL14 ▸
ADH5 ▸ REN ▸ ROR2 ▸ QRICH2 ▸ NTF4 ▸ RUNX2 ▸ NPY4R ▸
CXCL2 ▸ LYZ ▸ MICE ▸ PDAP1 ▸ ABCA4 ▸ WNT11 ▸ IRAK2 ▸
MKL1 ▸ CXCL5 ▸ WNT16 ▸ RB1 ▸ CRAT ▸ MAL ▸ CDH1 ▸
AIF1 ▸ AD5 ▸ POU5F1 ▸ NLRC5 ▸ CDK9 ▸ STK39 ▸ GAST ▸
IL1RAP ▸ NMU ▸ CD274 ▸ CXCL9 ▸ STK3 ▸ IGFBP4 ▸ BLVRB ▸
ADAM17 ▸ CREBBP ▸ FGFR2 ▸ LGALS3 ▸ RLN1 ▸ LCAT ▸ CXCL13 ▸
PDCD5 ▸ GSTM5 ▸ QRICH1 ▸ NANOG ▸ SLC39A14 ▸ PCK2 ▸ PTK2B ▸
SERPINA6 ▸ RAB7A ▸ STK24 ▸ PDCD10 ▸ MAP3K3 ▸ CNR2 ▸ FYN ▸
CX3CL1 ▸ CALM1 ▸ CDKN2A ▸ COQ5 ▸ RLN2 ▸ TSN ▸ CCR6 ▸
GSTM4 ▸ CCK ▸ STK4 ▸ MTA1 ▸ VCP ▸ PDCD1 ▸ VHLL ▸
HDAC11 ▸ DEFB114 ▸ ACR ▸ APOA4 ▸ SPN ▸ BDNF ▸ COQ6 ▸
MYO19 ▸ P2RY6 ▸ SCG2 ▸ P2RX1 ▸ MYO6 ▸ COQ7 ▸ WAS ▸
STK33 ▸ XIAP ▸ VIMP ▸ SERPING1 ▸ MIA ▸ HDAC4 ▸ BAI3 ▸
STK36 ▸ PHB ▸ HBD ▸ ACSM3 ▸ NR0B1 ▸ BSG ▸ IGF1R ▸
PDCD7 ▸ CALCA ▸ CXCR3 ▸ SERPINB5 ▸ IRG1 ▸ BAI2 ▸ ABCG2 ▸
PRNP ▸ ACE2 ▸ KDR ▸ CPA1 ▸ SERPINE2 ▸ HDAC7 ▸ PARK7 ▸
CEACAM1 ▸ ICOS ▸ PC ▸ SERPINA1 ▸ TAC4 ▸ CALM2 ▸ AZU1 ▸
ECM2 ▸ CXCL3 ▸ MYO10 ▸ TBCC ▸ RABEPK ▸ TNFAIP6 ▸ MSC ▸
RAB7B ▸ GCLC ▸ CD69 ▸ OXA1L ▸ WNT3 ▸ ARG2 ▸ HDAC9 ▸
SH3GL2 ▸ PTGER4 ▸ ZBTB16 ▸ MEOX2 ▸ F12 ▸ PRKD1 ▸ KAT2B ▸
ERBB3 ▸ PTPRE ▸ PIK3C3 ▸ CBL ▸ NFKB2 ▸ GCSAM ▸ HNRNPA1 ▸
FOXO1 ▸ PIAS1 ▸
Data information
Please see the Gene Interactions Track Manual.