Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766818-22771617)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ IL5 ▸ VEGFA ▸ IL18 ▸ IL21 ▸
TLR3 ▸ ICAM1 ▸ IL33 ▸ PTGS2 ▸ IL22 ▸ IL7 ▸ TLR9 ▸
FGB ▸ CD40 ▸ IL32 ▸ INS ▸ CCL2 ▸ IL11 ▸ IL15 ▸
IL19 ▸ JAK2 ▸ IL24 ▸ IL31 ▸ IL20 ▸ IL6ST ▸ IL26 ▸
IL25 ▸ IL34 ▸ IL16 ▸ JUN ▸ IL9 ▸ IL37 ▸ SOCS3 ▸
NOS2 ▸ IL27 ▸ TLR5 ▸ TLR1 ▸ TLR7 ▸ STAT1 ▸ TLR8 ▸
TLR10 ▸ TLR6 ▸ PTH ▸ IL12B ▸ SOAT1 ▸ SAA1 ▸ IL1RN ▸
CSRP1 ▸ AKT2 ▸ AKT3 ▸ AKT1 ▸ JAK1 ▸ FOS ▸ CD79A ▸
LEP ▸ IL12A ▸ LRPPRC ▸ PIK3CA ▸ VIP ▸ PIK3R1 ▸ RNF19A ▸
LTA ▸ CRK ▸ LIF ▸ CDC73 ▸ WDR61 ▸ CTR9 ▸ LEO1 ▸
CD40LG ▸ MMP1 ▸ ADCYAP1 ▸ PTX3 ▸ PAF1 ▸ FGF2 ▸ PRKAB2 ▸
PRKAG2 ▸ PRKAA1 ▸ PRKAG1 ▸ PRKAB1 ▸ PRKAA2 ▸ IL6R ▸ GP6 ▸
GP2 ▸ PTX4 ▸ GP5 ▸ GP9 ▸ HGF ▸ MYLIP ▸ MMP3 ▸
MMP9 ▸ IGF1 ▸ EDN1 ▸ GRAP2 ▸ TCF3 ▸ MMP2 ▸ JAK3 ▸
CRH ▸ TCF24 ▸ TCF15 ▸ TCF23 ▸ TCF7 ▸ MYD88 ▸ TCF4 ▸
TCF19 ▸ CD4 ▸ TCF12 ▸ CISH ▸ TCF25 ▸ TCF21 ▸ TCF20 ▸
MMP13 ▸ TGFB3 ▸ IFNB1 ▸ CA2 ▸ NOS3 ▸ PLG ▸ A2M ▸
MCL1 ▸ TGFB2 ▸ AHSA1 ▸ PAM ▸ TIMP1 ▸ OSM ▸ NOS1 ▸
HP ▸ CD14 ▸ PGF ▸ HNRNPF ▸ HMGB1 ▸ PTBP1 ▸ CD46 ▸
HNRNPH1 ▸ CEBPB ▸ PTBP2 ▸ CSF1 ▸ CASP3 ▸ APOB ▸ MT3 ▸
NA ▸ AR ▸ STAT5A ▸ NFKBIA ▸ NOX4 ▸ ALB ▸ PRG3 ▸
TAT ▸ TNFSF11 ▸ PRG2 ▸ PRG4 ▸ S100A12 ▸ PI3 ▸ CASP4 ▸
PRKAR1A ▸ NGF ▸ CASP1 ▸ CASP9 ▸ CASP7 ▸ CASP8 ▸ CASP14 ▸
PRKAR2A ▸ PRKAR2B ▸ NOX5 ▸ CASP12 ▸ PRKACG ▸ NOX1 ▸ CASP10 ▸
CASP6 ▸ CSF3 ▸ PRKAR1B ▸ NOX3 ▸ CASP2 ▸ PRKACB ▸ CASP5 ▸
CASP16 ▸ PRL ▸ VCAM1 ▸ SOCS1 ▸ ITIH4 ▸ MT4 ▸ LPA ▸
FOXP3 ▸ FAS ▸ GPI ▸ POLDIP2 ▸ PDGFB ▸ ANGPT2 ▸ MMP10 ▸
CALM3 ▸ CYP19A1 ▸ SELE ▸ MMP11 ▸ FASLG ▸ CD8A ▸ MMP14 ▸
SYT1 ▸ SPP1 ▸ SOD1 ▸ MMP7 ▸ SOD3 ▸ SAA2 ▸ LBP ▸
IKBKB ▸ SOD2 ▸ HMOX1 ▸ CEBPA ▸ NUP43 ▸ PTPN11 ▸ TNFRSF11B ▸
MMP8 ▸ APP ▸ ANG ▸ PLA2G1B ▸ IFI44 ▸ BCL2 ▸ IRF1 ▸
MMP12 ▸ EGF ▸ SETBP1 ▸ MMP19 ▸ MMP28 ▸ LPL ▸ MMP15 ▸
ALG1 ▸ MMP26 ▸ CALML3 ▸ MMP21 ▸ MMP17 ▸ SERPINE1 ▸ MMP27 ▸
CPOX ▸ HDAC1 ▸ CCL3 ▸ MMP20 ▸ CTSB ▸ MMP24 ▸ MMP16 ▸
F2RL1 ▸ NAALADL1 ▸ ADIPOQ ▸ MMP25 ▸ FCER2 ▸ CD28 ▸ AGTR2 ▸
MSH6 ▸ CSK ▸ FGF7 ▸ NPS ▸ MIF ▸ PPARG ▸ ERVK-6 ▸
MAP3K7 ▸ LTF ▸ AGT ▸ APC ▸ HES1 ▸ BCL3 ▸ SAA4 ▸
BCL6 ▸ PRDX2 ▸ GH1 ▸ PTHLH ▸ TYR ▸ PTPRC ▸ MSH3 ▸
FGF23 ▸ PLA2G4A ▸ HDAC2 ▸ GFAP ▸ FGF4 ▸ IRAK4 ▸ IL23A ▸
SERPINA3 ▸ FGF1 ▸ FGF8 ▸ MSH5 ▸ F2R ▸ ABCC1 ▸ CHUK ▸
FGF20 ▸ CEACAM5 ▸ FGF11 ▸ SMAD3 ▸ FGF10 ▸ IFNA2 ▸ FGF18 ▸
FGF16 ▸ CREB1 ▸ FGF22 ▸ FGF9 ▸ FGF5 ▸ MSH4 ▸ FGF12 ▸
TP53 ▸ FGF17 ▸ PPARA ▸ IL1R1 ▸ MTX1 ▸ IGF2 ▸ FGF6 ▸
FGF14 ▸ CUL1 ▸ KITLG ▸ FGF21 ▸ MSH2 ▸ CREB3 ▸ CREB5 ▸
SKP1 ▸ FGF3 ▸ FGF13 ▸ PDLIM7 ▸ IL2RA ▸ FGF19 ▸ LTB ▸
IFNA10 ▸ CD44 ▸ CDKN1A ▸ IFNA1 ▸ CXCL12 ▸ MTOR ▸ MAP2K1 ▸
HES7 ▸ PTK6 ▸ CD8B ▸ SST ▸ MPO ▸ HSPD1 ▸ IFNA13 ▸
IFNA8 ▸ HES2 ▸ CCL5 ▸ IFNA6 ▸ IFNA16 ▸ MRXS5 ▸ PTK7 ▸
IFNA5 ▸ IFNA4 ▸ TRAF6 ▸ ANXA1 ▸ HES4 ▸ IFNA7 ▸ TXN ▸
EGFR ▸ HES6 ▸ SMAD2 ▸ HES5 ▸ CEBPD ▸ HES3 ▸ ESR1 ▸
BMP2 ▸ IFNA21 ▸ PTK2 ▸ IFNA17 ▸ IFNA14 ▸ RHO ▸ EPO ▸
UCN ▸ CXCL1 ▸ AVP ▸ CXCL10 ▸ CNTN2 ▸ ANPEP ▸ TFPI ▸
SMAD7 ▸ WNK1 ▸ RENBP ▸ PAEP ▸ C4BPA ▸ SMAD4 ▸ FCGR1A ▸
RBBP4 ▸ CNTF ▸ KLK3 ▸ CAV3 ▸ HSPB1 ▸ IKBKG ▸ CAV2 ▸
IDO1 ▸ MUC1 ▸ MAP2K4 ▸ NPY ▸ PRKCA ▸ NAMPT ▸ SP1 ▸
P2RX7 ▸ CAV1 ▸ RBBP7 ▸ STAT4 ▸ BAX ▸ HAMP ▸ NM ▸
RAG1 ▸ S100B ▸ ADCY4 ▸ SAP30 ▸ SELP ▸ SAP130 ▸ BCL10 ▸
TNFRSF1A ▸ ADCY2 ▸ SELL ▸ ARID4B ▸ ADCY3 ▸ CYP3A4 ▸ SMAD6 ▸
SMAD5 ▸ NPEPPS ▸ ADCY5 ▸ PDCD11 ▸ ADM ▸ CHAT ▸ STS ▸
GZMB ▸ SRC ▸ MBP ▸ AGTR1 ▸ RAG2 ▸ HIF1A ▸ TGFA ▸
ACE ▸ CCR5 ▸ ADCY1 ▸ TAB1 ▸ ADCY8 ▸ NOD2 ▸ ADCY9 ▸
ADCY6 ▸ ADCY10 ▸ HDC ▸ ACP2 ▸ SHC1 ▸ IRF3 ▸ MUC4 ▸
IRS1 ▸ HLA-DRB1 ▸ SUDS3 ▸ TNFRSF1B ▸ REL ▸ IFI27 ▸ GCG ▸
MET ▸ DUSP1 ▸ ADCY7 ▸ CD5 ▸ GIF ▸ IL17RA ▸ SMAD9 ▸
CAT ▸ CSE ▸ SYK ▸ BMP6 ▸ JUND ▸ HLA-DRA ▸ IRAK1 ▸
DDIT3 ▸ SMAD1 ▸ BMP7 ▸ CORT ▸ WNT5A ▸ CD86 ▸ CLEC7A ▸
NOD1 ▸ SIN3A ▸ NPPA ▸ BCL5 ▸ IRF4 ▸ EDN3 ▸ IBD6 ▸
UTP20 ▸ GRB2 ▸ CR2 ▸ MUC16 ▸ REG1A ▸ UTP3 ▸ ANXA6 ▸
HRAS ▸ BCL9 ▸ MUC8 ▸ IL17D ▸ IRAK3 ▸ OPRM1 ▸ BMP1 ▸
AHR ▸ IL17F ▸ ATP8A2 ▸ CYP1A1 ▸ UTP23 ▸ EIF2AK2 ▸ UTP15 ▸
ITGB1 ▸ LGALS1 ▸ ZFP36 ▸ SFTPC ▸ ICAM4 ▸ VAV1 ▸ CTF1 ▸
MUC15 ▸ MUC21 ▸ MAP2K3 ▸ MUC17 ▸ IBD9 ▸ IBD3 ▸ POMC ▸
EDN2 ▸ IBD7 ▸ MAP2K7 ▸ UTP18 ▸ TPO ▸ INA ▸ CTGF ▸
S100A9 ▸ CXCL17 ▸ TNFSF13B ▸ ABCB1 ▸ ICAM5 ▸ TYK2 ▸ MPG ▸
MUC12 ▸ PTGS1 ▸ CCND1 ▸ ARSA ▸ PGP ▸ MAP2K5 ▸ PPP2CA ▸
MUC22 ▸ ICOSLG ▸ CCL20 ▸ BTRC ▸ PIGA ▸ TNFRSF8 ▸ HMGCR ▸
HSP90AB1 ▸ HSPG2 ▸ MUC2 ▸ PLD2 ▸ IBD2 ▸ ICAM2 ▸ PLD1 ▸
IBD5 ▸ TF ▸ MOG ▸ NCAM1 ▸ APOE ▸ MUC19 ▸ RETN ▸
ICAM3 ▸ IBD8 ▸ MAP2K6 ▸ ATF3 ▸ SETD2 ▸ MUC7 ▸ MUC13 ▸
FGFR3 ▸ UTP6 ▸ ST2 ▸ CYP3A ▸ ADORA1 ▸ HSF1 ▸ NLRP3 ▸
S100A8 ▸ PDGFA ▸ IBD4 ▸ MUC20 ▸ CTSL ▸ MAP2K2 ▸ MUC6 ▸
PTPN4 ▸ SEA ▸ IGFBP1 ▸ CXCL6 ▸ PARP10 ▸ ABL1 ▸ HCL2 ▸
XBP1 ▸ NEUROD2 ▸ HSP90AA1 ▸ EPS8 ▸ PARP4 ▸ ETS1 ▸ CPB1 ▸
BMP5 ▸ BMP4 ▸ PPP2R1A ▸ HDAC3 ▸ LYN ▸ CRYGEP ▸ GPX1 ▸
SLPI ▸ PARP3 ▸ ETS2 ▸ PARK2 ▸ DNMT1 ▸ CLU ▸ C5AR1 ▸
CD2 ▸ HSPA5 ▸ C1orf228 ▸ PLD4 ▸ NFATC2 ▸ PDCD4 ▸ GTF2B ▸
C1QB ▸ CIB1 ▸ GPX8 ▸ PIM1 ▸ C1QA ▸ CTSS ▸ GPX4 ▸
PITX2 ▸ WNT4 ▸ HPD ▸ CCL1 ▸ PLD6 ▸ BGLAP ▸ IL1R2 ▸
GPX3 ▸ GHRH ▸ CSH2 ▸ FXR1 ▸ ATP5O ▸ CD1D ▸ IRF8 ▸
TRNAI1 ▸ GYS1 ▸ OAS3 ▸ ACHE ▸ FXYD1 ▸ CD163 ▸ EPX ▸
WNT10B ▸ PLD3 ▸ CD19 ▸ PARP16 ▸ THBD ▸ PARP12 ▸ PGD ▸
PARP1 ▸ BCR ▸ MAPKAPK2 ▸ TIMP2 ▸ TRPV1 ▸ PARP14 ▸ GYS2 ▸
ITGAM ▸ GPX7 ▸ OPN1LW ▸ HCL1 ▸ FXR2 ▸ NTF3 ▸ ESR2 ▸
TNPO1 ▸ IRF5 ▸ TGM2 ▸ TEC ▸ PTS ▸ CHGA ▸ LCN2 ▸
PCK1 ▸ GNRH1 ▸ ROR1 ▸ CA1 ▸ OAS2 ▸ GPX2 ▸ HSPB3 ▸
MPL ▸ HCL3 ▸ BTK ▸ IGFBP3 ▸ MS4A1 ▸ AHSG ▸ EBP ▸
ATP7A ▸ PARP8 ▸ NEUROD4 ▸ RPL17 ▸ GAL ▸ ANGPT1 ▸ CPB2 ▸
XRCC1 ▸ CD80 ▸ KNG1 ▸ NEUROD6 ▸ TRAF2 ▸ PARP15 ▸ IRF9 ▸
PARP11 ▸ PON1 ▸ MAF ▸ OAS1 ▸ BMP10 ▸ TSLP ▸ NEUROD1 ▸
IDS ▸ CXCR4 ▸ PLD5 ▸ SERPINF1 ▸ PARP9 ▸ UCN2 ▸ HDAC6 ▸
GPX6 ▸ BMP3 ▸ EPS15 ▸ PARP6 ▸ CYP1A2 ▸ NDP ▸ BPI ▸
SCARB1 ▸ CX3CR1 ▸ NNMT ▸ PPP2R2B ▸ GPX5 ▸ PARP2 ▸ FOXO3 ▸
GNA13 ▸ FUT4 ▸ BMP15 ▸ HCK ▸ ADORA3 ▸ ADH4 ▸ ANGPT4 ▸
MTA1 ▸ ECM2 ▸ STK3 ▸ CEBPZ ▸ CHP2 ▸ KRT37 ▸ CDH1 ▸
MUC5AC ▸ TTR ▸ ADH5 ▸ STEAP4 ▸ KLRB1 ▸ SMC4 ▸ NR0B1 ▸
TBP ▸ EEF1A2 ▸ JUNB ▸ ACAN ▸ REN ▸ QRICH1 ▸ CD34 ▸
GSTM3 ▸ STK31 ▸ PLAT ▸ IRF7 ▸ TNC ▸ PDCD1 ▸ PARK7 ▸
TAC4 ▸ AMELX ▸ CD69 ▸ HDAC5 ▸ WNT6 ▸ HDAC10 ▸ IL2RG ▸
LYZ ▸ FLOT2 ▸ STK24 ▸ SMC6 ▸ HSPB8 ▸ TRAF5 ▸ RLN2 ▸
SLC39A14 ▸ TRAF3IP2 ▸ ATF4 ▸ SDC1 ▸ NTS ▸ GSTM5 ▸ SP3 ▸
CDKN2A ▸ VCP ▸ NR4A1 ▸ WAS ▸ NMU ▸ GSTM2 ▸ CX3CL1 ▸
RAB7B ▸ TRAF1 ▸ GAST ▸ RAF1 ▸ PSMB9 ▸ COQ9 ▸ SCG3 ▸
CCL4 ▸ QRICH2 ▸ CCR2 ▸ STK16 ▸ PPP5C ▸ TAC1 ▸ BAI1 ▸
CD59 ▸ HDAC8 ▸ WNT16 ▸ STK19 ▸ LGALS3 ▸ BAI3 ▸ CREBBP ▸
ACD ▸ PINK1 ▸ ITGA5 ▸ MIP ▸ STK11 ▸ AZU1 ▸ ECM1 ▸
E2F1 ▸ HDAC7 ▸ IGFBP2 ▸ SAA3P ▸ HCFC1 ▸ TGM7 ▸ GSTM1 ▸
TRD ▸ CXCL3 ▸ TNFAIP6 ▸ CD33 ▸ APOA4 ▸ FMR1 ▸ MAP3K3 ▸
STK36 ▸ IGFBP4 ▸ LRG1 ▸ COQ3 ▸ SFTPA1 ▸ COL1A1 ▸ CEACAM1 ▸
MTA2 ▸ SMN1 ▸ OXA1L ▸ RAB7A ▸ ARG2 ▸ CXCL13 ▸ VWF ▸
DERL1 ▸ TBCC ▸ MIA ▸ ROR2 ▸ SERPING1 ▸ STK4 ▸ KRT13 ▸
TNFSF10 ▸ ATF1 ▸ MYC ▸ PDCD6 ▸ ADH7 ▸ PC ▸ ADAM17 ▸
IGFBP7 ▸ MSC ▸ PDCD5 ▸ C5 ▸ DYNLRB1 ▸ CDK4 ▸ UCN3 ▸
EGR1 ▸ P2RX1 ▸ P2RY6 ▸ WNT2 ▸ ACE2 ▸ PLA2G2D ▸ CD274 ▸
AREG ▸ BLVRB ▸ CHP1 ▸ CXCL16 ▸ STK35 ▸ TIMP3 ▸ ACR ▸
KDR ▸ MCS ▸ CXCR3 ▸ PDAP1 ▸ CCR6 ▸ ITGA2B ▸ THBS1 ▸
VHLL ▸ TFAP2A ▸ EREG ▸ GIP ▸ RAC1 ▸ SARS ▸ HDAC11 ▸
IGFBP5 ▸ CPA1 ▸ HBD ▸ NLRC5 ▸ WNT1 ▸ IGF1R ▸ WNT11 ▸
ABCG2 ▸ PCK2 ▸ GCLC ▸ CXCL2 ▸ MCC ▸ TGM4 ▸ XIAP ▸
ADIPOR1 ▸ CP ▸ WNT3 ▸ CRAT ▸ CCR1 ▸ RABEPK ▸ PTK2B ▸
STK10 ▸ SERPINE2 ▸ CNR2 ▸ COQ5 ▸ NPY4R ▸ CCK ▸ TIRAP ▸
CXCL14 ▸ RPS6KA3 ▸ NTF4 ▸ IRAK2 ▸ POU5F1 ▸ AD5 ▸ PTPN22 ▸
TSC22D3 ▸ LDLR ▸ CXCL11 ▸ FGL1 ▸ RUNX2 ▸ MAL ▸ CD1C ▸
NTN1 ▸ MKL1 ▸ IRF2 ▸ FLT3LG ▸ LCAT ▸ ARG1 ▸ FGFR2 ▸
SERPINB5 ▸ RASIP1 ▸ MYO6 ▸ ABCA4 ▸ STK39 ▸ GAS6 ▸ SERPINA6 ▸
CXCL9 ▸ DEFB114 ▸ CXCL5 ▸ MYO16 ▸ NT5E ▸ GSTM4 ▸ HDAC9 ▸
STK25 ▸ ACSM3 ▸ COQ7 ▸ SERPINA1 ▸ DEFB4B ▸ SCG2 ▸ ADH6 ▸
CALCA ▸ NOTCH2 ▸ TSN ▸ STK40 ▸ SPN ▸ COQ6 ▸ RNASE3 ▸
C3AR1 ▸ ASIP ▸ RBP4 ▸ CD38 ▸ ITGA4 ▸ SMC5 ▸ STK33 ▸
EDNRA ▸ VIMP ▸ ICOS ▸ SLC25A3 ▸ SLC33A1 ▸ CALM2 ▸ COQ4 ▸
PDCD7 ▸ IFIT1 ▸ MYO10 ▸ RLN1 ▸ RORC ▸ PIAS3 ▸ IRG1 ▸
NOTCH1 ▸ CDK9 ▸ OXTR ▸ HPX ▸ MEPE ▸ AIF1 ▸ SCG5 ▸
PRNP ▸ CDKN1B ▸ RLN3 ▸ BAI2 ▸ MYO19 ▸ PDCD10 ▸ SMC2 ▸
SOS1 ▸ CALM1 ▸ MICE ▸ IL2RB ▸ NANOG ▸ MTA3 ▸ STK38 ▸
BSG ▸ IL1RAP ▸ HDAC4 ▸ FYN ▸ COQ2 ▸ BDNF ▸ TAC3 ▸
PHB ▸ RB1 ▸ KRT38 ▸ SMC3 ▸ APCS ▸ PDCD2 ▸ KRT10 ▸
PTGER4 ▸ CBL ▸ PTPRE ▸ HNRNPA1 ▸ NFKB2 ▸ ZBTB16 ▸ PIK3C3 ▸
GCSAM ▸ F12 ▸ PIAS1 ▸ MEOX2 ▸ PRKD1 ▸ KAT2B ▸ FOXO1 ▸
ERBB3 ▸ SH3GL2 ▸
Data information
Please see the Gene Interactions Track Manual.