Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766818-22771617)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
Gene:               Hide non-IL6 interactions     Show top Genes on graph    

Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ IL5 ▸ VEGFA ▸ IL18 ▸ IL21 ▸
TLR3 ▸ ICAM1 ▸ IL33 ▸ PTGS2 ▸ IL22 ▸ IL7 ▸ TLR9 ▸
FGB ▸ CD40 ▸ IL32 ▸ INS ▸ IL11 ▸ CCL2 ▸ IL15 ▸
IL19 ▸ IL31 ▸ IL24 ▸ JAK2 ▸ IL26 ▸ IL34 ▸ IL25 ▸
IL9 ▸ JUN ▸ IL20 ▸ IL6ST ▸ IL16 ▸ IL37 ▸ IL27 ▸
SOCS3 ▸ NOS2 ▸ TLR1 ▸ TLR5 ▸ TLR7 ▸ STAT1 ▸ TLR8 ▸
TLR10 ▸ TLR6 ▸ IL12B ▸ PTH ▸ SOAT1 ▸ SAA1 ▸ IL1RN ▸
CSRP1 ▸ AKT2 ▸ AKT3 ▸ AKT1 ▸ JAK1 ▸ FOS ▸ LEP ▸
CD79A ▸ IL12A ▸ LRPPRC ▸ PIK3CA ▸ VIP ▸ RNF19A ▸ PIK3R1 ▸
CRK ▸ LTA ▸ MMP1 ▸ CDC73 ▸ LIF ▸ LEO1 ▸ PAF1 ▸
CD40LG ▸ WDR61 ▸ ADCYAP1 ▸ CTR9 ▸ PTX3 ▸ PRKAB1 ▸ PRKAA2 ▸
PRKAB2 ▸ FGF2 ▸ PRKAG1 ▸ IL6R ▸ PRKAA1 ▸ PRKAG2 ▸ HGF ▸
GP6 ▸ GP2 ▸ GP5 ▸ GP9 ▸ PTX4 ▸ MMP3 ▸ MMP9 ▸
EDN1 ▸ IGF1 ▸ MYLIP ▸ GRAP2 ▸ MMP2 ▸ TCF3 ▸ CRH ▸
JAK3 ▸ TCF4 ▸ TCF15 ▸ TCF12 ▸ TCF21 ▸ TCF20 ▸ TCF7 ▸
TCF23 ▸ TCF24 ▸ TCF19 ▸ MYD88 ▸ CISH ▸ TCF25 ▸ CD4 ▸
MMP13 ▸ TGFB3 ▸ CA2 ▸ IFNB1 ▸ PLG ▸ MCL1 ▸ A2M ▸
NOS3 ▸ TGFB2 ▸ OSM ▸ AHSA1 ▸ TIMP1 ▸ PAM ▸ HP ▸
NOS1 ▸ CD14 ▸ PTBP2 ▸ PTBP1 ▸ CEBPB ▸ HNRNPF ▸ HMGB1 ▸
CD46 ▸ HNRNPH1 ▸ PGF ▸ AR ▸ NFKBIA ▸ CASP3 ▸ APOB ▸
MT3 ▸ NOX4 ▸ ALB ▸ STAT5A ▸ NA ▸ CSF1 ▸ S100A12 ▸
PRG2 ▸ PI3 ▸ PRG4 ▸ TNFSF11 ▸ PRG3 ▸ TAT ▸ PRKAR1A ▸
CSF3 ▸ CASP7 ▸ PRKACB ▸ NGF ▸ CASP8 ▸ CASP16 ▸ NOX1 ▸
CASP1 ▸ CASP12 ▸ PRKACG ▸ CASP14 ▸ PRKAR1B ▸ PRKAR2B ▸ CASP5 ▸
CASP2 ▸ PRKAR2A ▸ CASP4 ▸ CASP9 ▸ NOX5 ▸ CASP6 ▸ NOX3 ▸
CASP10 ▸ FOXP3 ▸ FAS ▸ GPI ▸ ITIH4 ▸ PDGFB ▸ POLDIP2 ▸
VCAM1 ▸ MT4 ▸ SOCS1 ▸ ANGPT2 ▸ LPA ▸ PRL ▸ SYT1 ▸
CALM3 ▸ CD8A ▸ SOD1 ▸ SELE ▸ SPP1 ▸ SAA2 ▸ MMP7 ▸
CYP19A1 ▸ SOD3 ▸ MMP10 ▸ MMP14 ▸ MMP11 ▸ FASLG ▸ NUP43 ▸
IRF1 ▸ IFI44 ▸ CEBPA ▸ IKBKB ▸ PTPN11 ▸ APP ▸ HMOX1 ▸
TNFRSF11B ▸ SOD2 ▸ BCL2 ▸ MMP8 ▸ LBP ▸ MMP12 ▸ PLA2G1B ▸
ANG ▸ MMP28 ▸ MMP19 ▸ MMP24 ▸ SERPINE1 ▸ MMP15 ▸ MMP16 ▸
FCER2 ▸ MMP27 ▸ CALML3 ▸ CCL3 ▸ LPL ▸ MMP17 ▸ EGF ▸
HDAC1 ▸ NAALADL1 ▸ ALG1 ▸ ADIPOQ ▸ F2RL1 ▸ CD28 ▸ MMP25 ▸
MMP26 ▸ MMP21 ▸ CPOX ▸ MMP20 ▸ SETBP1 ▸ CTSB ▸ SAA4 ▸
GFAP ▸ CSK ▸ FGF23 ▸ MSH6 ▸ FGF4 ▸ FGF7 ▸ IL23A ▸
PPARG ▸ FGF1 ▸ BCL3 ▸ GH1 ▸ APC ▸ PRDX2 ▸ BCL6 ▸
HDAC2 ▸ MIF ▸ PLA2G4A ▸ LTF ▸ ERVK-6 ▸ AGT ▸ MSH3 ▸
NPS ▸ HES1 ▸ TYR ▸ SERPINA3 ▸ PTPRC ▸ IRAK4 ▸ MAP3K7 ▸
AGTR2 ▸ PTHLH ▸ CUL1 ▸ F2R ▸ PPARA ▸ TP53 ▸ PDLIM7 ▸
FGF20 ▸ FGF9 ▸ FGF11 ▸ FGF14 ▸ CHUK ▸ FGF17 ▸ FGF21 ▸
FGF22 ▸ IFNA2 ▸ FGF13 ▸ MTX1 ▸ IL2RA ▸ FGF10 ▸ FGF12 ▸
KITLG ▸ SKP1 ▸ SMAD3 ▸ MSH2 ▸ MSH5 ▸ MSH4 ▸ FGF19 ▸
FGF6 ▸ IGF2 ▸ ABCC1 ▸ FGF3 ▸ CREB1 ▸ FGF18 ▸ LTB ▸
FGF16 ▸ CREB5 ▸ IL1R1 ▸ FGF8 ▸ CREB3 ▸ CEACAM5 ▸ FGF5 ▸
IFNA16 ▸ IFNA4 ▸ MRXS5 ▸ RHO ▸ HES3 ▸ HES7 ▸ MPO ▸
IFNA6 ▸ PTK2 ▸ EPO ▸ IFNA14 ▸ ESR1 ▸ TXN ▸ PTK6 ▸
SMAD2 ▸ UCN ▸ HES6 ▸ IFNA1 ▸ CD44 ▸ CDKN1A ▸ ANXA1 ▸
CCL5 ▸ IFNA7 ▸ MTOR ▸ BMP2 ▸ CEBPD ▸ TRAF6 ▸ HES5 ▸
SST ▸ IFNA21 ▸ IFNA5 ▸ HES4 ▸ CXCL12 ▸ IFNA17 ▸ MAP2K1 ▸
EGFR ▸ CD8B ▸ IFNA13 ▸ HSPD1 ▸ IFNA10 ▸ IFNA8 ▸ HES2 ▸
PTK7 ▸ CNTN2 ▸ TFPI ▸ WNK1 ▸ IDO1 ▸ CAV2 ▸ SMAD7 ▸
NAMPT ▸ IKBKG ▸ AVP ▸ MUC1 ▸ RENBP ▸ CXCL10 ▸ CAV1 ▸
RBBP4 ▸ MAP2K4 ▸ CNTF ▸ RBBP7 ▸ BAX ▸ KLK3 ▸ ANPEP ▸
SMAD4 ▸ CXCL1 ▸ NPY ▸ PRKCA ▸ SP1 ▸ HAMP ▸ CAV3 ▸
FCGR1A ▸ STAT4 ▸ PAEP ▸ C4BPA ▸ P2RX7 ▸ HSPB1 ▸ TGFA ▸
ADCY3 ▸ CAT ▸ NM ▸ JUND ▸ ADCY8 ▸ BCL10 ▸ MBP ▸
WNT5A ▸ SUDS3 ▸ CHAT ▸ SMAD1 ▸ IL17RA ▸ PDCD11 ▸ SELL ▸
ACP2 ▸ ADCY9 ▸ ADCY5 ▸ SRC ▸ SMAD5 ▸ ADCY4 ▸ SAP30 ▸
HDC ▸ NPEPPS ▸ TAB1 ▸ MUC4 ▸ DDIT3 ▸ SHC1 ▸ GIF ▸
NPPA ▸ IFI27 ▸ ADM ▸ CYP3A4 ▸ RAG2 ▸ CCR5 ▸ GCG ▸
ADCY2 ▸ CD5 ▸ CD86 ▸ AGTR1 ▸ TNFRSF1B ▸ SIN3A ▸ GZMB ▸
ADCY6 ▸ BMP6 ▸ IRS1 ▸ IRAK1 ▸ NOD1 ▸ STS ▸ HLA-DRB1 ▸
REL ▸ TNFRSF1A ▸ CORT ▸ DUSP1 ▸ SELP ▸ SMAD6 ▸ HIF1A ▸
ADCY1 ▸ ADCY10 ▸ MET ▸ HLA-DRA ▸ CLEC7A ▸ ACE ▸ IRF3 ▸
CSE ▸ BMP7 ▸ RAG1 ▸ SYK ▸ NOD2 ▸ ADCY7 ▸ S100B ▸
SMAD9 ▸ ARID4B ▸ SAP130 ▸ TNFRSF8 ▸ ADORA1 ▸ MUC7 ▸ CTF1 ▸
ABCB1 ▸ PPP2CA ▸ S100A8 ▸ MUC22 ▸ ATF3 ▸ SETD2 ▸ UTP3 ▸
UTP23 ▸ ICAM2 ▸ MUC15 ▸ CTGF ▸ MPG ▸ MUC17 ▸ MUC2 ▸
IBD7 ▸ CXCL17 ▸ CTSL ▸ ICAM4 ▸ SFTPC ▸ IL17D ▸ HSPG2 ▸
BMP1 ▸ MUC21 ▸ UTP20 ▸ MOG ▸ TNFSF13B ▸ APOE ▸ MUC19 ▸
IBD5 ▸ MUC12 ▸ POMC ▸ IBD3 ▸ TPO ▸ IBD6 ▸ INA ▸
EDN2 ▸ CYP1A1 ▸ IRAK3 ▸ IL17F ▸ HRAS ▸ HSF1 ▸ IRF4 ▸
FGFR3 ▸ IBD8 ▸ ST2 ▸ IBD2 ▸ REG1A ▸ ICAM5 ▸ ANXA6 ▸
ICAM3 ▸ ATP8A2 ▸ PDGFA ▸ MUC8 ▸ HMGCR ▸ UTP6 ▸ MAP2K2 ▸
ICOSLG ▸ LGALS1 ▸ MAP2K5 ▸ MUC6 ▸ MUC16 ▸ BCL9 ▸ ARSA ▸
PTPN4 ▸ ITGB1 ▸ HSP90AB1 ▸ NLRP3 ▸ PLD2 ▸ NCAM1 ▸ MAP2K7 ▸
TF ▸ VAV1 ▸ UTP15 ▸ PLD1 ▸ EIF2AK2 ▸ CYP3A ▸ CCND1 ▸
CR2 ▸ PTGS1 ▸ MUC13 ▸ S100A9 ▸ PGP ▸ SEA ▸ BCL5 ▸
MAP2K3 ▸ TYK2 ▸ IBD9 ▸ CCL20 ▸ IGFBP1 ▸ IBD4 ▸ UTP18 ▸
GRB2 ▸ MAP2K6 ▸ BTRC ▸ AHR ▸ MUC20 ▸ RETN ▸ EDN3 ▸
ZFP36 ▸ PIGA ▸ OPRM1 ▸ CXCL6 ▸ IRF8 ▸ TRAF2 ▸ BCR ▸
PARP10 ▸ GYS1 ▸ CRYGEP ▸ HSP90AA1 ▸ PARP1 ▸ GPX2 ▸ NEUROD1 ▸
PPP2R2B ▸ EPX ▸ TGM2 ▸ HCK ▸ XBP1 ▸ CD19 ▸ RPL17 ▸
TRPV1 ▸ ATP5O ▸ NEUROD2 ▸ HCL2 ▸ HSPB3 ▸ PARP8 ▸ TIMP2 ▸
PLD6 ▸ HPD ▸ PLD4 ▸ ETS2 ▸ NDP ▸ PGD ▸ GPX7 ▸
PITX2 ▸ NNMT ▸ GHRH ▸ GPX4 ▸ CD2 ▸ IRF5 ▸ SERPINF1 ▸
GPX8 ▸ HCL3 ▸ XRCC1 ▸ GPX1 ▸ PARP15 ▸ LYN ▸ BMP4 ▸
TNPO1 ▸ PPP2R1A ▸ PARP2 ▸ FXR1 ▸ PLD5 ▸ PON1 ▸ ABL1 ▸
C1QB ▸ PARP6 ▸ SCARB1 ▸ PARP9 ▸ IRF9 ▸ CPB1 ▸ BTK ▸
OPN1LW ▸ PARP12 ▸ BMP15 ▸ GPX3 ▸ BMP5 ▸ WNT10B ▸ CSH2 ▸
BPI ▸ SLPI ▸ HSPA5 ▸ ETS1 ▸ C1QA ▸ ITGAM ▸ PARP4 ▸
CCL1 ▸ GYS2 ▸ LCN2 ▸ CD80 ▸ HDAC6 ▸ PARP11 ▸ ACHE ▸
PTS ▸ GPX6 ▸ IGFBP3 ▸ TRNAI1 ▸ CYP1A2 ▸ OAS1 ▸ EPS15 ▸
GNA13 ▸ IDS ▸ NFATC2 ▸ TEC ▸ NEUROD4 ▸ MAF ▸ OAS3 ▸
NTF3 ▸ PARP14 ▸ MPL ▸ CD1D ▸ CTSS ▸ TSLP ▸ CIB1 ▸
WNT4 ▸ CX3CR1 ▸ CXCR4 ▸ EPS8 ▸ BMP3 ▸ GTF2B ▸ ATP7A ▸
BMP10 ▸ FOXO3 ▸ FUT4 ▸ FXR2 ▸ AHSG ▸ CLU ▸ GNRH1 ▸
OAS2 ▸ PLD3 ▸ FXYD1 ▸ PIM1 ▸ PARP3 ▸ ADORA3 ▸ PARK2 ▸
IL1R2 ▸ HCL1 ▸ ANGPT1 ▸ UCN2 ▸ MS4A1 ▸ GAL ▸ PDCD4 ▸
PCK1 ▸ NEUROD6 ▸ CD163 ▸ CHGA ▸ CA1 ▸ ROR1 ▸ THBD ▸
C5AR1 ▸ BGLAP ▸ DNMT1 ▸ EBP ▸ C1orf228 ▸ HDAC3 ▸ GPX5 ▸
ESR2 ▸ CPB2 ▸ MAPKAPK2 ▸ PARP16 ▸ KNG1 ▸ SLC25A3 ▸ BDNF ▸
SMN1 ▸ IL2RB ▸ CP ▸ ABCA4 ▸ TAC1 ▸ KDR ▸ MAL ▸
KRT10 ▸ STK35 ▸ TSC22D3 ▸ WNT2 ▸ THBS1 ▸ IRG1 ▸ PSMB9 ▸
MTA2 ▸ PDCD1 ▸ TIMP3 ▸ AZU1 ▸ ACSM3 ▸ RABEPK ▸ STK19 ▸
ACD ▸ IGFBP4 ▸ ABCG2 ▸ CXCR3 ▸ STK36 ▸ CD38 ▸ GSTM1 ▸
HDAC5 ▸ STK40 ▸ STEAP4 ▸ ROR2 ▸ COQ6 ▸ SMC6 ▸ RAB7A ▸
LCAT ▸ SARS ▸ ITGA2B ▸ GAS6 ▸ FLT3LG ▸ MKL1 ▸ APCS ▸
HDAC7 ▸ HDAC11 ▸ SCG5 ▸ CXCL5 ▸ CXCL14 ▸ ITGA5 ▸ IL2RG ▸
MYO6 ▸ SERPING1 ▸ HPX ▸ SCG2 ▸ ACR ▸ ANGPT4 ▸ FGFR2 ▸
OXTR ▸ IL1RAP ▸ CHP2 ▸ SDC1 ▸ LDLR ▸ HSPB8 ▸ RUNX2 ▸
SMC5 ▸ AD5 ▸ NMU ▸ NOTCH1 ▸ CD274 ▸ LYZ ▸ LGALS3 ▸
NTS ▸ SAA3P ▸ MIP ▸ STK25 ▸ XIAP ▸ CXCL2 ▸ PHB ▸
HDAC9 ▸ FYN ▸ TBP ▸ SP3 ▸ STK33 ▸ PIAS3 ▸ TNFAIP6 ▸
TAC4 ▸ SMC4 ▸ POU5F1 ▸ SLC39A14 ▸ UCN3 ▸ IGFBP2 ▸ EGR1 ▸
PLAT ▸ SFTPA1 ▸ CPA1 ▸ ICOS ▸ MCC ▸ STK24 ▸ AREG ▸
E2F1 ▸ IRF2 ▸ PCK2 ▸ MYC ▸ CALM2 ▸ CX3CL1 ▸ WAS ▸
HDAC4 ▸ NR0B1 ▸ COQ9 ▸ VHLL ▸ SMC3 ▸ ECM2 ▸ GSTM4 ▸
COQ7 ▸ CXCL9 ▸ BAI3 ▸ PDCD6 ▸ QRICH2 ▸ CCR1 ▸ CCR2 ▸
APOA4 ▸ MUC5AC ▸ P2RX1 ▸ ACAN ▸ CALM1 ▸ CEBPZ ▸ NLRC5 ▸
PRNP ▸ SOS1 ▸ PDCD10 ▸ TGM4 ▸ BSG ▸ BAI1 ▸ MTA3 ▸
RAC1 ▸ MAP3K3 ▸ COQ2 ▸ CD59 ▸ IGFBP5 ▸ STK3 ▸ TAC3 ▸
RBP4 ▸ GAST ▸ VCP ▸ STK16 ▸ PDCD2 ▸ MYO19 ▸ NTN1 ▸
VWF ▸ CNR2 ▸ GIP ▸ ATF4 ▸ SPN ▸ MICE ▸ STK38 ▸
RNASE3 ▸ PTPN22 ▸ GSTM2 ▸ PTK2B ▸ RLN3 ▸ ADH4 ▸ STK4 ▸
NPY4R ▸ STK10 ▸ STK11 ▸ AIF1 ▸ CD69 ▸ VIMP ▸ MYO16 ▸
MEPE ▸ MYO10 ▸ CXCL16 ▸ PDAP1 ▸ WNT1 ▸ MTA1 ▸ CHP1 ▸
CREBBP ▸ TNC ▸ KLRB1 ▸ NR4A1 ▸ SCG3 ▸ HBD ▸ LRG1 ▸
CEACAM1 ▸ ASIP ▸ CDKN2A ▸ SLC33A1 ▸ PDCD5 ▸ PDCD7 ▸ ARG1 ▸
AMELX ▸ ADH5 ▸ KRT37 ▸ PLA2G2D ▸ QRICH1 ▸ ADH7 ▸ CD1C ▸
COQ5 ▸ BLVRB ▸ TRAF3IP2 ▸ NTF4 ▸ PPP5C ▸ ADH6 ▸ P2RY6 ▸
SERPINA1 ▸ NT5E ▸ CD33 ▸ HDAC10 ▸ IGF1R ▸ STK39 ▸ PINK1 ▸
TGM7 ▸ OXA1L ▸ DYNLRB1 ▸ CCL4 ▸ CALCA ▸ ECM1 ▸ NANOG ▸
RASIP1 ▸ HDAC8 ▸ TBCC ▸ RLN1 ▸ TSN ▸ CCK ▸ CCR6 ▸
SMC2 ▸ DEFB4B ▸ FLOT2 ▸ ADIPOR1 ▸ IFIT1 ▸ GSTM5 ▸ IRAK2 ▸
WNT6 ▸ FGL1 ▸ MCS ▸ TRD ▸ CD34 ▸ KRT38 ▸ WNT16 ▸
COQ3 ▸ TFAP2A ▸ WNT3 ▸ CXCL11 ▸ TRAF5 ▸ ITGA4 ▸ C5 ▸
ARG2 ▸ RORC ▸ IGFBP7 ▸ SERPINE2 ▸ TRAF1 ▸ KRT13 ▸ EDNRA ▸
TIRAP ▸ JUNB ▸ CXCL3 ▸ SERPINB5 ▸ FMR1 ▸ MSC ▸ ACE2 ▸
PC ▸ ATF1 ▸ RB1 ▸ C3AR1 ▸ CDKN1B ▸ RPS6KA3 ▸ COL1A1 ▸
TNFSF10 ▸ CRAT ▸ HCFC1 ▸ MIA ▸ RLN2 ▸ CXCL13 ▸ STK31 ▸
PARK7 ▸ GSTM3 ▸ CDH1 ▸ DERL1 ▸ GCLC ▸ ADAM17 ▸ RAF1 ▸
CDK9 ▸ WNT11 ▸ REN ▸ CDK4 ▸ RAB7B ▸ COQ4 ▸ EREG ▸
TTR ▸ DEFB114 ▸ EEF1A2 ▸ BAI2 ▸ SERPINA6 ▸ NOTCH2 ▸ IRF7 ▸
MEOX2 ▸ ERBB3 ▸ HNRNPA1 ▸ ZBTB16 ▸ NFKB2 ▸ PTGER4 ▸ PIAS1 ▸
PRKD1 ▸ KAT2B ▸ CBL ▸ F12 ▸ PTPRE ▸ FOXO1 ▸ SH3GL2 ▸
PIK3C3 ▸ GCSAM ▸
Data information
Please see the Gene Interactions Track Manual.