ID:THAP5_HUMAN DESCRIPTION: RecName: Full=THAP domain-containing protein 5; FUNCTION: Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560). SUBUNIT: Interacts with HTRA2; under apoptotic conditions (PubMed:19502560). Interacts with ABRAXAS2 (PubMed:21195082). SUBCELLULAR LOCATION: Nucleus TISSUE SPECIFICITY: Detected in heart (PubMed:19502560, PubMed:21195082). Detected in brain and muscle (at protein level) (PubMed:19502560). Highly expressed in the heart. Also found in brain and skeletal muscle (PubMed:19502560, PubMed:21195082). INDUCTION: Up-regulated both in response to UV light treatment and cisplatin, agents that cause DNA damage (at protein level). PTM: Cleaved by HTRA2 during apoptosis. SEQUENCE CAUTION: Sequence=AAH53634.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=EAL24383.1; Type=Erroneous gene model prediction; Evidence=;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z6K1
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Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0002020 protease binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007049 cell cycle GO:0045786 negative regulation of cell cycle