Human Gene THAP5 (ENST00000415914.4_6) from GENCODE V45lift37
  Description: Homo sapiens THAP domain containing 5 (THAP5), transcript variant 5, mRNA. (from RefSeq NM_001287601)
Gencode Transcript: ENST00000415914.4_6
Gencode Gene: ENSG00000177683.14_9
Transcript (Including UTRs)
   Position: hg19 chr7:108,202,576-108,210,150 Size: 7,575 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr7:108,204,635-108,210,013 Size: 5,379 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2024-04-24 11:59:55

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:108,202,576-108,210,150)mRNA (may differ from genome)Protein (395 aa)
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HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: THAP5_HUMAN
DESCRIPTION: RecName: Full=THAP domain-containing protein 5;
FUNCTION: Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560).
SUBUNIT: Interacts with HTRA2; under apoptotic conditions (PubMed:19502560). Interacts with ABRAXAS2 (PubMed:21195082).
SUBCELLULAR LOCATION: Nucleus
TISSUE SPECIFICITY: Detected in heart (PubMed:19502560, PubMed:21195082). Detected in brain and muscle (at protein level) (PubMed:19502560). Highly expressed in the heart. Also found in brain and skeletal muscle (PubMed:19502560, PubMed:21195082).
INDUCTION: Up-regulated both in response to UV light treatment and cisplatin, agents that cause DNA damage (at protein level).
PTM: Cleaved by HTRA2 during apoptosis.
SEQUENCE CAUTION: Sequence=AAH53634.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=EAL24383.1; Type=Erroneous gene model prediction; Evidence=;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): THAP5
CDC HuGE Published Literature: THAP5

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.17 RPKM in Testis
Total median expression: 262.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.80137-0.451 Picture PostScript Text
3' UTR -508.702059-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006612 - THAP_Znf

Pfam Domains:
PF05485 - THAP domain

ModBase Predicted Comparative 3D Structure on Q7Z6K1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0002020 protease binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007049 cell cycle
GO:0045786 negative regulation of cell cycle

Cellular Component:
GO:0000790 nuclear chromatin
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC016973 - Homo sapiens cDNA clone IMAGE:3915000, **** WARNING: chimeric clone ****.
AL833137 - Homo sapiens mRNA; cDNA DKFZp313O1132 (from clone DKFZp313O1132).
JD340459 - Sequence 321483 from Patent EP1572962.
JD290776 - Sequence 271800 from Patent EP1572962.
JD174216 - Sequence 155240 from Patent EP1572962.
JD435408 - Sequence 416432 from Patent EP1572962.
JD480143 - Sequence 461167 from Patent EP1572962.
JD218413 - Sequence 199437 from Patent EP1572962.
BC040353 - Homo sapiens cDNA clone IMAGE:4706453, **** WARNING: chimeric clone ****.
JD473405 - Sequence 454429 from Patent EP1572962.
JD552761 - Sequence 533785 from Patent EP1572962.
JD072916 - Sequence 53940 from Patent EP1572962.
JD541289 - Sequence 522313 from Patent EP1572962.
JD160196 - Sequence 141220 from Patent EP1572962.
JD291109 - Sequence 272133 from Patent EP1572962.
JD152871 - Sequence 133895 from Patent EP1572962.
JD500910 - Sequence 481934 from Patent EP1572962.
JD325821 - Sequence 306845 from Patent EP1572962.
JD367173 - Sequence 348197 from Patent EP1572962.
JD413631 - Sequence 394655 from Patent EP1572962.
JD206164 - Sequence 187188 from Patent EP1572962.
JD499188 - Sequence 480212 from Patent EP1572962.
JD489615 - Sequence 470639 from Patent EP1572962.
JD046586 - Sequence 27610 from Patent EP1572962.
JD176728 - Sequence 157752 from Patent EP1572962.
JD433753 - Sequence 414777 from Patent EP1572962.
JD036420 - Sequence 17444 from Patent EP1572962.
BC053634 - Homo sapiens THAP domain containing 5, mRNA (cDNA clone MGC:61780 IMAGE:5165075), complete cds.
JD311401 - Sequence 292425 from Patent EP1572962.
HQ448603 - Synthetic construct Homo sapiens clone IMAGE:100072041; CCSB011828_03 THAP domain containing 5 (THAP5) gene, encodes complete protein.
CU691016 - Synthetic construct Homo sapiens gateway clone IMAGE:100021317 5' read THAP5 mRNA.
JD371469 - Sequence 352493 from Patent EP1572962.
JD302199 - Sequence 283223 from Patent EP1572962.
JD530102 - Sequence 511126 from Patent EP1572962.
JD418998 - Sequence 400022 from Patent EP1572962.
JD052583 - Sequence 33607 from Patent EP1572962.
JD254219 - Sequence 235243 from Patent EP1572962.
LF209522 - JP 2014500723-A/17025: Polycomb-Associated Non-Coding RNAs.
MA445099 - JP 2018138019-A/17025: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000415914.1, ENST00000415914.2, ENST00000415914.3, NM_001287601, Q7Z6K1, THAP5_HUMAN, uc319lse.1
UCSC ID: ENST00000415914.4_6
RefSeq Accession: NM_001130475
Protein: Q7Z6K1 (aka THAP5_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.