Human Gene TACSTD2 (ENST00000371225.4_5) from GENCODE V45lift37
  Description: Homo sapiens tumor associated calcium signal transducer 2 (TACSTD2), mRNA. (from RefSeq NM_002353)
RefSeq Summary (NM_002353): This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009].
Gencode Transcript: ENST00000371225.4_5
Gencode Gene: ENSG00000184292.7_7
Transcript (Including UTRs)
   Position: hg19 chr1:59,041,105-59,042,924 Size: 1,820 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr1:59,041,857-59,042,828 Size: 972 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2024-04-24 11:59:55

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:59,041,105-59,042,924)mRNA (may differ from genome)Protein (323 aa)
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-  Comments and Description Text from UniProtKB
  ID: TACD2_HUMAN
DESCRIPTION: RecName: Full=Tumor-associated calcium signal transducer 2; AltName: Full=Cell surface glycoprotein Trop-2; AltName: Full=Membrane component chromosome 1 surface marker 1; AltName: Full=Pancreatic carcinoma marker protein GA733-1; Flags: Precursor;
FUNCTION: May function as a growth factor receptor.
INTERACTION: P09758; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-4324738, EBI-11749135; P09758; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-4324738, EBI-10171774; P09758; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-4324738, EBI-11958178; P09758; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-4324738, EBI-11973993;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Placenta, pancreatic carcinoma cell lines.
PTM: The N-terminus is blocked.
DISEASE: Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity. Note=The disease is caused by variants affecting the gene represented in this entry.
SIMILARITY: Belongs to the EPCAM family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TACSTD2
Diseases sorted by gene-association score: corneal dystrophy, gelatinous drop-like* (1391), lattice corneal dystrophy (26), corneal dystrophy (19), epithelial and subepithelial dystrophy (19), taeniasis (11), coenurosis (7), corneal dystrophy, reis-bucklers type (7), epithelial-stromal tgfbi dystrophy (7), cysticercosis (5), chandler syndrome (5), corneal dystrophy, thiel-behnke type (4), tyrosinemia, type ii (4), corneal disease (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 702.27 RPKM in Esophagus - Mucosa
Total median expression: 2474.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.6096-0.235 Picture PostScript Text
3' UTR -198.70752-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR049420 - EPCAM-Trop-2_C
IPR043406 - EPCAM/Trop-2
IPR041630 - EpCAM_N
IPR000716 - Thyroglobulin_1
IPR036857 - Thyroglobulin_1_sf

Pfam Domains:
PF21283 - n/a
PF18635 - n/a
PF00086 - Thyroglobulin type-1 repeat

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2MAE - NMR 2MVK - NMR 2MVL - NMR 7E5M - X-ray 7E5N - X-ray 7PEE - X-ray


ModBase Predicted Comparative 3D Structure on P09758
FrontTopSide
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007601 visual perception
GO:0010633 negative regulation of epithelial cell migration
GO:0050678 regulation of epithelial cell proliferation
GO:0050896 response to stimulus
GO:0051497 negative regulation of stress fiber assembly
GO:0060675 ureteric bud morphogenesis
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1900028 negative regulation of ruffle assembly
GO:2000146 negative regulation of cell motility
GO:2000738 positive regulation of stem cell differentiation

Cellular Component:
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  X77753 - H.sapiens TROP-2 gene.
LF212041 - JP 2014500723-A/19544: Polycomb-Associated Non-Coding RNAs.
X77754 - H.sapiens TROP-2 mRNA.
BC009409 - Homo sapiens tumor-associated calcium signal transducer 2, mRNA (cDNA clone MGC:10655 IMAGE:3611756), complete cds.
X13425 - Human mRNA for pancreatic carcinoma marker GA733-1.
LF213043 - JP 2014500723-A/20546: Polycomb-Associated Non-Coding RNAs.
JD316745 - Sequence 297769 from Patent EP1572962.
JD363605 - Sequence 344629 from Patent EP1572962.
JD322417 - Sequence 303441 from Patent EP1572962.
JD289348 - Sequence 270372 from Patent EP1572962.
JD228546 - Sequence 209570 from Patent EP1572962.
JD373726 - Sequence 354750 from Patent EP1572962.
JD050294 - Sequence 31318 from Patent EP1572962.
JD390597 - Sequence 371621 from Patent EP1572962.
DQ895835 - Synthetic construct Homo sapiens clone IMAGE:100010295; FLH188115.01L; RZPDo839G08149D tumor-associated calcium signal transducer 2 (TACSTD2) gene, encodes complete protein.
KJ897153 - Synthetic construct Homo sapiens clone ccsbBroadEn_06547 TACSTD2 gene, encodes complete protein.
DQ892601 - Synthetic construct clone IMAGE:100005231; FLH188119.01X; RZPDo839G08150D tumor-associated calcium signal transducer 2 (TACSTD2) gene, encodes complete protein.
BT007255 - Homo sapiens tumor-associated calcium signal transducer 2 mRNA, complete cds.
CR542260 - Homo sapiens full open reading frame cDNA clone RZPDo834A1126D for gene TACSTD2, tumor-associated calcium signal transducer 2; complete cds, incl. stopcodon.
MA447618 - JP 2018138019-A/19544: Polycomb-Associated Non-Coding RNAs.
MA448620 - JP 2018138019-A/20546: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000371225.1, ENST00000371225.2, ENST00000371225.3, GA733-1, M1S1, NM_002353, P09758, Q15658, Q6FG48, Q7Z7Q4, Q96QD2, TACD2_HUMAN, TROP2, uc318izs.1
UCSC ID: ENST00000371225.4_5
RefSeq Accession: NM_002353
Protein: P09758 (aka TACD2_HUMAN or TTD2_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.