Human Gene TACSTD2 (ENST00000371225.4_5) from GENCODE V45lift37
Description: Homo sapiens tumor associated calcium signal transducer 2 (TACSTD2), mRNA. (from RefSeq NM_002353) RefSeq Summary (NM_002353): This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]. Gencode Transcript: ENST00000371225.4_5 Gencode Gene: ENSG00000184292.7_7 Transcript (Including UTRs) Position: hg19 chr1:59,041,105-59,042,924 Size: 1,820 Total Exon Count: 1 Strand: - Coding Region Position: hg19 chr1:59,041,857-59,042,828 Size: 972 Coding Exon Count: 1
ID:TACD2_HUMAN DESCRIPTION: RecName: Full=Tumor-associated calcium signal transducer 2; AltName: Full=Cell surface glycoprotein Trop-2; AltName: Full=Membrane component chromosome 1 surface marker 1; AltName: Full=Pancreatic carcinoma marker protein GA733-1; Flags: Precursor; FUNCTION: May function as a growth factor receptor. INTERACTION: P09758; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-4324738, EBI-11749135; P09758; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-4324738, EBI-10171774; P09758; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-4324738, EBI-11958178; P09758; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-4324738, EBI-11973993; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Placenta, pancreatic carcinoma cell lines. PTM: The N-terminus is blocked. DISEASE: Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity. Note=The disease is caused by variants affecting the gene represented in this entry. SIMILARITY: Belongs to the EPCAM family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09758
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Gene Ontology (GO) Annotations with Structured Vocabulary