Human Gene SUCNR1 (ENST00000362032.6_3) from GENCODE V45lift37
Description: Homo sapiens succinate receptor 1 (SUCNR1), mRNA. (from RefSeq NM_033050) RefSeq Summary (NM_033050): This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000362032.6_3 Gencode Gene: ENSG00000198829.6_6 Transcript (Including UTRs) Position: hg19 chr3:151,591,431-151,602,407 Size: 10,977 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr3:151,597,681-151,599,336 Size: 1,656 Coding Exon Count: 2
ID:SUCR1_HUMAN DESCRIPTION: RecName: Full=Succinate receptor 1 ; AltName: Full=G-protein coupled receptor 91; AltName: Full=P2Y purinoceptor 1-like; FUNCTION: G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (By similarity) (PubMed:15141213, PubMed:34133934, PubMed:23770096). Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis (PubMed:18820681, PubMed:34133934). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (By similarity). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involoved in immune function (PubMed:34133934). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (By similarity). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (PubMed:18820681). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity (By similarity). In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner (By similarity). In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (By similarity). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (By similarity). INTERACTION: Q9BXA5; P13473-2: LAMP2; NbExp=3; IntAct=EBI-17962797, EBI-21591415; Q9BXA5; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-17962797, EBI-2623095; Q9BXA5; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-17962797, EBI-8638294; SUBCELLULAR LOCATION: Cell membrane ; Multi-pass membrane protein TISSUE SPECIFICITY: Expressed specifically in kidney (PubMed:11273702). Highly expressed in immature dendritic cells, expression rapidly downregulates after maturation. Also expressed in macrophages (PubMed:18820681). SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CAUTION: It is uncertain whether Met-1 or Met-5 is the initiator. SEQUENCE CAUTION: Sequence=AAK29080.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BXA5
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Gene Ontology (GO) Annotations with Structured Vocabulary
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
