Triglycerides Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903299]
Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04503 - Single-stranded DNA binding protein, SSDP
ModBase Predicted Comparative 3D Structure on Q9BWW4
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Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0002244 hematopoietic progenitor cell differentiation GO:0008284 positive regulation of cell proliferation GO:0021501 prechordal plate formation GO:0021547 midbrain-hindbrain boundary initiation GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048382 mesendoderm development GO:0060322 head development GO:0060323 head morphogenesis GO:0065003 macromolecular complex assembly GO:2000744 positive regulation of anterior head development