Human Gene SOCS1 (ENST00000332029.4_5) from GENCODE V45lift37
  Description: Homo sapiens suppressor of cytokine signaling 1 (SOCS1), mRNA. (from RefSeq NM_003745)
RefSeq Summary (NM_003745): This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000332029.4_5
Gencode Gene: ENSG00000185338.7_8
Transcript (Including UTRs)
   Position: hg19 chr16:11,348,274-11,350,061 Size: 1,788 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr16:11,348,700-11,349,335 Size: 636 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2024-04-24 11:59:55

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:11,348,274-11,350,061)mRNA (may differ from genome)Protein (211 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q4JHT5_HUMAN
DESCRIPTION: SubName: Full=Suppressor of cytokine signaling 1 ;
PATHWAY: Protein modification; protein ubiquitination.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SOCS1
Diseases sorted by gene-association score: infectious anterior uveitis (15), primary biliary cholangitis (6), congenital muscular dystrophy due to lmna mutation (5), lymphadenitis (5), hepatocellular carcinoma (3), colorectal cancer (3), essential thrombocythemia (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.58 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 204.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.80176-0.442 Picture PostScript Text
3' UTR -157.90426-0.371 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000980 - SH2
IPR036860 - SH2_dom_sf
IPR035861 - SOCS1_SH2
IPR001496 - SOCS_box
IPR036036 - SOCS_box-like_dom_sf

Pfam Domains:
PF00017 - SH2 domain
PF07525 - SOCS box

ModBase Predicted Comparative 3D Structure on Q4JHT5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019210 kinase inhibitor activity

Biological Process:
GO:0001932 regulation of protein phosphorylation
GO:0007259 JAK-STAT cascade
GO:0010533 regulation of activation of Janus kinase activity
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0033673 negative regulation of kinase activity
GO:0035556 intracellular signal transduction
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045444 fat cell differentiation
GO:0046425 regulation of JAK-STAT cascade
GO:0046426 negative regulation of JAK-STAT cascade
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050707 regulation of cytokine secretion
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0071230 cellular response to amino acid stimulus

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0036464 cytoplasmic ribonucleoprotein granule


-  Descriptions from all associated GenBank mRNAs
  LF212663 - JP 2014500723-A/20166: Polycomb-Associated Non-Coding RNAs.
AB000676 - Homo sapiens mRNA for JAB, partial cds.
U88326 - Human suppressor of cytokine signalling-1 (SOCS-1) mRNA, complete cds.
AB000734 - Homo sapiens mRNA for TIP3, complete cds.
AK127621 - Homo sapiens cDNA FLJ45719 fis, clone FELNG2001953, highly similar to Suppressor of cytokine signaling 1.
AB005043 - Homo sapiens mRNA for STAT induced STAT inhibitor-1, complete cds.
JD563134 - Sequence 544158 from Patent EP1572962.
JD172996 - Sequence 154020 from Patent EP1572962.
JD487558 - Sequence 468582 from Patent EP1572962.
JD075868 - Sequence 56892 from Patent EP1572962.
JD540226 - Sequence 521250 from Patent EP1572962.
JD560245 - Sequence 541269 from Patent EP1572962.
JD416045 - Sequence 397069 from Patent EP1572962.
BC148542 - Synthetic construct Homo sapiens clone IMAGE:100015498, MGC:183062 suppressor of cytokine signaling 1 (SOCS1) mRNA, encodes complete protein.
BC153088 - Synthetic construct Homo sapiens clone IMAGE:100016379, MGC:184312 suppressor of cytokine signaling 1 (SOCS1) mRNA, encodes complete protein.
AB464719 - Synthetic construct DNA, clone: pF1KB8763, Homo sapiens SOCS1 gene for suppressor of cytokine signaling 1, without stop codon, in Flexi system.
BC029307 - Homo sapiens suppressor of cytokine signaling 1, mRNA (cDNA clone IMAGE:5179306), with apparent retained intron.
JD474898 - Sequence 455922 from Patent EP1572962.
MA448240 - JP 2018138019-A/20166: Polycomb-Associated Non-Coding RNAs.
MP067513 - Sequence 17 from Patent WO2018232288.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000332029.1, ENST00000332029.2, ENST00000332029.3, hCG_14617, NM_003745, Q4JHT5, Q4JHT5_HUMAN, uc317tio.1
UCSC ID: ENST00000332029.4_5
RefSeq Accession: NM_003745
Protein: Q4JHT5

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.