Human Gene SOCS1 (ENST00000332029.4_5) from GENCODE V45lift37
Description: Homo sapiens suppressor of cytokine signaling 1 (SOCS1), mRNA. (from RefSeq NM_003745) RefSeq Summary (NM_003745): This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000332029.4_5 Gencode Gene: ENSG00000185338.7_8 Transcript (Including UTRs) Position: hg19 chr16:11,348,274-11,350,061 Size: 1,788 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr16:11,348,700-11,349,335 Size: 636 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q4JHT5
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Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0001932 regulation of protein phosphorylation GO:0007259 JAK-STAT cascade GO:0010533 regulation of activation of Janus kinase activity GO:0016567 protein ubiquitination GO:0019221 cytokine-mediated signaling pathway GO:0033673 negative regulation of kinase activity GO:0035556 intracellular signal transduction GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation GO:0043377 negative regulation of CD8-positive, alpha-beta T cell differentiation GO:0045444 fat cell differentiation GO:0046425 regulation of JAK-STAT cascade GO:0046426 negative regulation of JAK-STAT cascade GO:0046627 negative regulation of insulin receptor signaling pathway GO:0050707 regulation of cytokine secretion GO:0060334 regulation of interferon-gamma-mediated signaling pathway GO:0071230 cellular response to amino acid stimulus