Human Gene SLC25A10 (ENST00000350690.10_6) from GENCODE V45lift37
  Description: Homo sapiens solute carrier family 25 member 10 (SLC25A10), transcript variant 2, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_012140)
RefSeq Summary (NM_012140): This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
Gencode Transcript: ENST00000350690.10_6
Gencode Gene: ENSG00000183048.12_10
Transcript (Including UTRs)
   Position: hg19 chr17:79,679,314-79,688,042 Size: 8,729 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr17:79,679,457-79,687,107 Size: 7,651 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2024-04-24 11:59:55

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:79,679,314-79,688,042)mRNA (may differ from genome)Protein (287 aa)
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-  Comments and Description Text from UniProtKB
  ID: DIC_HUMAN
DESCRIPTION: RecName: Full=Mitochondrial dicarboxylate carrier ; Short=DIC; AltName: Full=Solute carrier family 25 member 10;
FUNCTION: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:29211846). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity).
CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in); Xref=Rhea:RHEA:71607, ChEBI:CHEBI:15589, ChEBI:CHEBI:43474; Evidence=;
CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + malonate(out) = (S)-malate(out) + malonate(in); Xref=Rhea:RHEA:71611, ChEBI:CHEBI:15589, ChEBI:CHEBI:15792; Evidence=;
CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in); Xref=Rhea:RHEA:29327, ChEBI:CHEBI:15589, ChEBI:CHEBI:30031; Evidence=;
CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in); Xref=Rhea:RHEA:71615, ChEBI:CHEBI:15589, ChEBI:CHEBI:16189; Evidence=;
CATALYTIC ACTIVITY: Reaction=malonate(out) + phosphate(in) = malonate(in) + phosphate(out); Xref=Rhea:RHEA:71623, ChEBI:CHEBI:15792, ChEBI:CHEBI:43474; Evidence=;
CATALYTIC ACTIVITY: Reaction=phosphate(in) + succinate(out) = phosphate(out) + succinate(in); Xref=Rhea:RHEA:71627, ChEBI:CHEBI:30031, ChEBI:CHEBI:43474; Evidence=;
CATALYTIC ACTIVITY: Reaction=phosphate(in) + sulfate(out) = phosphate(out) + sulfate(in); Xref=Rhea:RHEA:71631, ChEBI:CHEBI:16189, ChEBI:CHEBI:43474; Evidence=;
CATALYTIC ACTIVITY: Reaction=malonate(out) + succinate(in) = malonate(in) + succinate(out); Xref=Rhea:RHEA:71667, ChEBI:CHEBI:15792, ChEBI:CHEBI:30031; Evidence=;
INTERACTION: Q9UBX3; Q6A162: KRT40; NbExp=3; IntAct=EBI-750394, EBI-10171697; Q9UBX3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-750394, EBI-10171774; Q9UBX3; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-750394, EBI-10172511; Q9UBX3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-750394, EBI-3958099; Q9UBX3; Q99750: MDFI; NbExp=7; IntAct=EBI-750394, EBI-724076; Q9UBX3; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-750394, EBI-945833; Q9UBX3-2; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-12056597, EBI-3958099; Q9UBX3-2; Q99750: MDFI; NbExp=3; IntAct=EBI-12056597, EBI-724076; Q9UBX3-2; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-12056597, EBI-1210429;
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.
DISEASE: Mitochondrial DNA depletion syndrome 19 (MTDPS19) [MIM:618972]: An autosomal recessive mitochondrial disorder characterized by progressive and severe epileptic encephalopathy, hypotonia, poor spontaneous movements evolving to spastic quadriparesis and dyskinesias, and respiratory complex I deficiency and mitochondrial DNA depletion in skeletal muscle. Note=The disease may be caused by variants affecting the gene represented in this entry.
SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.

-  Primer design for this transcript
 

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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D016604 Aflatoxin B1
  • D001564 Benzo(a)pyrene
  • D013749 Tetrachlorodibenzodioxin
  • D020122 tert-Butylhydroperoxide
  • C049325 1,2-dithiol-3-thione
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C023035 3,4,5,3',4'-pentachlorobiphenyl
  • C009505 4,4'-diaminodiphenylmethane
  • D015127 9,10-Dimethyl-1,2-benzanthracene
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.34 RPKM in Testis
Total median expression: 63.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.40143-0.548 Picture PostScript Text
3' UTR -438.20935-0.469 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002030 - Mit_uncoupling_UCP-like
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom_sf

Pfam Domains:
PF00153 - Mitochondrial carrier protein

ModBase Predicted Comparative 3D Structure on Q9UBX3
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005310 dicarboxylic acid transmembrane transporter activity
GO:0005515 protein binding
GO:0015116 sulfate transmembrane transporter activity
GO:0015117 thiosulfate transmembrane transporter activity
GO:0015131 oxaloacetate transmembrane transporter activity
GO:0015140 malate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015297 antiporter activity

Biological Process:
GO:0006094 gluconeogenesis
GO:0006811 ion transport
GO:0006835 dicarboxylic acid transport
GO:0006839 mitochondrial transport
GO:0008272 sulfate transport
GO:0015709 thiosulfate transport
GO:0015729 oxaloacetate transport
GO:0035435 phosphate ion transmembrane transport
GO:0070221 sulfide oxidation, using sulfide:quinone oxidoreductase
GO:0071422 succinate transmembrane transport
GO:0071423 malate transmembrane transport
GO:1902356 oxaloacetate(2-) transmembrane transport
GO:1902358 sulfate transmembrane transport

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane


-  Descriptions from all associated GenBank mRNAs
  AK297076 - Homo sapiens cDNA FLJ60124 complete cds, highly similar to Mitochondrial dicarboxylate carrier.
BC015797 - Homo sapiens solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10, mRNA (cDNA clone MGC:8903 IMAGE:3909361), complete cds.
BC007355 - Homo sapiens solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10, mRNA (cDNA clone MGC:16077 IMAGE:3617078), complete cds.
AK075249 - Homo sapiens cDNA FLJ90768 fis, clone THYRO1000795, highly similar to Mitochondrial dicarboxylate carrier.
AJ131613 - Homo sapiens mRNA for dicarboxylate carrier protein.
JD482495 - Sequence 463519 from Patent EP1572962.
DQ893263 - Synthetic construct clone IMAGE:100005893; FLH195729.01X; RZPDo839F08152D solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (SLC25A10) gene, encodes complete protein.
DQ896592 - Synthetic construct Homo sapiens clone IMAGE:100011052; FLH195725.01L; RZPDo839F08151D solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (SLC25A10) gene, encodes complete protein.
CU675633 - Synthetic construct Homo sapiens gateway clone IMAGE:100016971 5' read SLC25A10 mRNA.
KJ890989 - Synthetic construct Homo sapiens clone ccsbBroadEn_00383 SLC25A10 gene, encodes complete protein.
KJ901362 - Synthetic construct Homo sapiens clone ccsbBroadEn_10756 SLC25A10 gene, encodes complete protein.
KU177998 - Homo sapiens solute carrier family 25 member 10 isoform 1 (SLC25A10) mRNA, partial cds, alternatively spliced.
KU177999 - Homo sapiens solute carrier family 25 member 10 isoform 2 (SLC25A10) mRNA, partial cds.
KU178000 - Homo sapiens solute carrier family 25 member 10 isoform 3 (SLC25A10) mRNA, partial cds, alternatively spliced.
AK303808 - Homo sapiens cDNA FLJ61034 complete cds, highly similar to Mitochondrial dicarboxylate carrier.
JD313990 - Sequence 295014 from Patent EP1572962.
JD319911 - Sequence 300935 from Patent EP1572962.
JD466398 - Sequence 447422 from Patent EP1572962.
JD065953 - Sequence 46977 from Patent EP1572962.
JD180306 - Sequence 161330 from Patent EP1572962.
JD341831 - Sequence 322855 from Patent EP1572962.
JD120451 - Sequence 101475 from Patent EP1572962.
JD067972 - Sequence 48996 from Patent EP1572962.
JD544942 - Sequence 525966 from Patent EP1572962.
JD197923 - Sequence 178947 from Patent EP1572962.
JD326656 - Sequence 307680 from Patent EP1572962.
JD561654 - Sequence 542678 from Patent EP1572962.
JD509031 - Sequence 490055 from Patent EP1572962.
JD070712 - Sequence 51736 from Patent EP1572962.
JD162008 - Sequence 143032 from Patent EP1572962.
JD483723 - Sequence 464747 from Patent EP1572962.
JD408867 - Sequence 389891 from Patent EP1572962.
JD141866 - Sequence 122890 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UBX3 (Reactome details) participates in the following event(s):

R-HSA-372843 malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]
R-HSA-1614546 Sulfate is exported to the cytosol in exchange for dicarboxylate
R-HSA-70263 Gluconeogenesis
R-HSA-428643 Organic anion transporters
R-HSA-1614517 Sulfide oxidation to sulfate
R-HSA-70326 Glucose metabolism
R-HSA-425374 Amino acid and oligopeptide SLC transporters
R-HSA-425393 Metabolism of nitrogenous molecules
R-HSA-1614558 Degradation of cysteine and homocysteine
R-HSA-71387 Metabolism of carbohydrates
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-1614635 Sulfur amino acid metabolism
R-HSA-1430728 Metabolism
R-HSA-382551 Transport of small molecules
R-HSA-71291 Metabolism of nitrogenous molecules

-  Other Names for This Gene
  Alternate Gene Symbols: DIC, DIC_HUMAN, ENST00000350690.1, ENST00000350690.2, ENST00000350690.3, ENST00000350690.4, ENST00000350690.5, ENST00000350690.6, ENST00000350690.7, ENST00000350690.8, ENST00000350690.9, NM_012140, Q542Z3, Q96BA1, Q96IP1, Q9UBX3, uc317xzy.1
UCSC ID: ENST00000350690.10_6
RefSeq Accession: NM_012140
Protein: Q9UBX3 (aka DIC_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.