Human Gene SLC25A10 (ENST00000350690.10_6) from GENCODE V45lift37
Description: Homo sapiens solute carrier family 25 member 10 (SLC25A10), transcript variant 2, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_012140)
RefSeq Summary (NM_012140): This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
Gencode Transcript: ENST00000350690.10_6
Gencode Gene: ENSG00000183048.12_10
Transcript (Including UTRs)
Position: hg19 chr17:79,679,314-79,688,042 Size: 8,729 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr17:79,679,457-79,687,107 Size: 7,651 Coding Exon Count: 11
Data last updated at UCSC: 2024-04-24 11:59:55
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: DIC_HUMAN
DESCRIPTION: RecName: Full=Mitochondrial dicarboxylate carrier ; Short=DIC; AltName: Full=Solute carrier family 25 member 10;
FUNCTION: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:29211846). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity).CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in); Xref=Rhea:RHEA:71607, ChEBI:CHEBI:15589, ChEBI:CHEBI:43474; Evidence=;CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + malonate(out) = (S)-malate(out) + malonate(in); Xref=Rhea:RHEA:71611, ChEBI:CHEBI:15589, ChEBI:CHEBI:15792; Evidence=;CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + succinate(out) = (S)-malate(out) + succinate(in); Xref=Rhea:RHEA:29327, ChEBI:CHEBI:15589, ChEBI:CHEBI:30031; Evidence=;CATALYTIC ACTIVITY: Reaction=(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in); Xref=Rhea:RHEA:71615, ChEBI:CHEBI:15589, ChEBI:CHEBI:16189; Evidence=;CATALYTIC ACTIVITY: Reaction=malonate(out) + phosphate(in) = malonate(in) + phosphate(out); Xref=Rhea:RHEA:71623, ChEBI:CHEBI:15792, ChEBI:CHEBI:43474; Evidence=;CATALYTIC ACTIVITY: Reaction=phosphate(in) + succinate(out) = phosphate(out) + succinate(in); Xref=Rhea:RHEA:71627, ChEBI:CHEBI:30031, ChEBI:CHEBI:43474; Evidence=;CATALYTIC ACTIVITY: Reaction=phosphate(in) + sulfate(out) = phosphate(out) + sulfate(in); Xref=Rhea:RHEA:71631, ChEBI:CHEBI:16189, ChEBI:CHEBI:43474; Evidence=;CATALYTIC ACTIVITY: Reaction=malonate(out) + succinate(in) = malonate(in) + succinate(out); Xref=Rhea:RHEA:71667, ChEBI:CHEBI:15792, ChEBI:CHEBI:30031; Evidence=;INTERACTION: Q9UBX3; Q6A162: KRT40; NbExp=3; IntAct=EBI-750394, EBI-10171697; Q9UBX3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-750394, EBI-10171774; Q9UBX3; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-750394, EBI-10172511; Q9UBX3; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-750394, EBI-3958099; Q9UBX3; Q99750: MDFI; NbExp=7; IntAct=EBI-750394, EBI-724076; Q9UBX3; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-750394, EBI-945833; Q9UBX3-2; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-12056597, EBI-3958099; Q9UBX3-2; Q99750: MDFI; NbExp=3; IntAct=EBI-12056597, EBI-724076; Q9UBX3-2; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-12056597, EBI-1210429;SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Present in high amounts in liver and kidney, and at lower levels in all the other tissues analyzed.DISEASE: Mitochondrial DNA depletion syndrome 19 (MTDPS19) [MIM:618972] : An autosomal recessive mitochondrial disorder characterized by progressive and severe epileptic encephalopathy, hypotonia, poor spontaneous movements evolving to spastic quadriparesis and dyskinesias, and respiratory complex I deficiency and mitochondrial DNA depletion in skeletal muscle. Note=The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D016604
Aflatoxin B1
D001564
Benzo(a)pyrene
D013749
Tetrachlorodibenzodioxin
D020122
tert-Butylhydroperoxide
C049325
1,2-dithiol-3-thione
C111118
2',3,3',4',5-pentachloro-4-hydroxybiphenyl
C049584
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
C023035
3,4,5,3',4'-pentachlorobiphenyl
C009505
4,4'-diaminodiphenylmethane
D015127
9,10-Dimethyl-1,2-benzanthracene
more ... click here to view the complete list
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002030 - Mit_uncoupling_UCP-like
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom_sf
Pfam Domains: PF00153 - Mitochondrial carrier protein
ModBase Predicted Comparative 3D Structure on Q9UBX3
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Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK297076 - Homo sapiens cDNA FLJ60124 complete cds, highly similar to Mitochondrial dicarboxylate carrier.BC015797 - Homo sapiens solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10, mRNA (cDNA clone MGC:8903 IMAGE:3909361), complete cds.BC007355 - Homo sapiens solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10, mRNA (cDNA clone MGC:16077 IMAGE:3617078), complete cds.AK075249 - Homo sapiens cDNA FLJ90768 fis, clone THYRO1000795, highly similar to Mitochondrial dicarboxylate carrier.AJ131613 - Homo sapiens mRNA for dicarboxylate carrier protein.JD482495 - Sequence 463519 from Patent EP1572962.DQ893263 - Synthetic construct clone IMAGE:100005893; FLH195729.01X; RZPDo839F08152D solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (SLC25A10) gene, encodes complete protein.DQ896592 - Synthetic construct Homo sapiens clone IMAGE:100011052; FLH195725.01L; RZPDo839F08151D solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (SLC25A10) gene, encodes complete protein.CU675633 - Synthetic construct Homo sapiens gateway clone IMAGE:100016971 5' read SLC25A10 mRNA.KJ890989 - Synthetic construct Homo sapiens clone ccsbBroadEn_00383 SLC25A10 gene, encodes complete protein.KJ901362 - Synthetic construct Homo sapiens clone ccsbBroadEn_10756 SLC25A10 gene, encodes complete protein.KU177998 - Homo sapiens solute carrier family 25 member 10 isoform 1 (SLC25A10) mRNA, partial cds, alternatively spliced.KU177999 - Homo sapiens solute carrier family 25 member 10 isoform 2 (SLC25A10) mRNA, partial cds.KU178000 - Homo sapiens solute carrier family 25 member 10 isoform 3 (SLC25A10) mRNA, partial cds, alternatively spliced.AK303808 - Homo sapiens cDNA FLJ61034 complete cds, highly similar to Mitochondrial dicarboxylate carrier.JD313990 - Sequence 295014 from Patent EP1572962.JD319911 - Sequence 300935 from Patent EP1572962.JD466398 - Sequence 447422 from Patent EP1572962.JD065953 - Sequence 46977 from Patent EP1572962.JD180306 - Sequence 161330 from Patent EP1572962.JD341831 - Sequence 322855 from Patent EP1572962.JD120451 - Sequence 101475 from Patent EP1572962.JD067972 - Sequence 48996 from Patent EP1572962.JD544942 - Sequence 525966 from Patent EP1572962.JD197923 - Sequence 178947 from Patent EP1572962.JD326656 - Sequence 307680 from Patent EP1572962.JD561654 - Sequence 542678 from Patent EP1572962.JD509031 - Sequence 490055 from Patent EP1572962.JD070712 - Sequence 51736 from Patent EP1572962.JD162008 - Sequence 143032 from Patent EP1572962.JD483723 - Sequence 464747 from Patent EP1572962.JD408867 - Sequence 389891 from Patent EP1572962.JD141866 - Sequence 122890 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: DIC, DIC_HUMAN, ENST00000350690.1, ENST00000350690.2, ENST00000350690.3, ENST00000350690.4, ENST00000350690.5, ENST00000350690.6, ENST00000350690.7, ENST00000350690.8, ENST00000350690.9, NM_012140, Q542Z3, Q96BA1, Q96IP1, Q9UBX3, uc317xzy.1UCSC ID: ENST00000350690.10_6RefSeq Accession: NM_012140
Protein: Q9UBX3
(aka DIC_HUMAN)
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.