Human Gene RPL24 (ENST00000394077.8_7) from GENCODE V45lift37
  Description: Homo sapiens ribosomal protein L24 (RPL24), mRNA. (from RefSeq NM_000986)
RefSeq Summary (NM_000986): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24E family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins from S. cerevisiae; however, its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000394077.8_7
Gencode Gene: ENSG00000114391.14_9
Transcript (Including UTRs)
   Position: hg19 chr3:101,399,935-101,405,562 Size: 5,628 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr3:101,399,979-101,405,520 Size: 5,542 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2024-04-24 11:59:55

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:101,399,935-101,405,562)mRNA (may differ from genome)Protein (157 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: V9HW01_HUMAN
DESCRIPTION: RecName: Full=Large ribosomal subunit protein eL24 ; AltName: Full=60S ribosomal protein L24 ;
SUBUNIT: Component of the large ribosomal subunit.
SUBCELLULAR LOCATION: Cytoplasm
SIMILARITY: Belongs to the eukaryotic ribosomal protein eL24 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: RPL24
Diseases sorted by gene-association score: bone resorption disease (2), bone remodeling disease (2), cauda equina neoplasm (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 884.08 RPKM in Ovary
Total median expression: 17965.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.6042-0.038 Picture PostScript Text
3' UTR -3.1044-0.070 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR038630 - L24e/L24_sf
IPR000988 - Ribosomal_eL24-rel
IPR023442 - Ribosomal_eL24_CS
IPR011017 - TRASH_dom

Pfam Domains:
PF01246 - Ribosomal protein L24e

ModBase Predicted Comparative 3D Structure on V9HW01
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
GO:0007093 mitotic cell cycle checkpoint
GO:0010458 exit from mitosis
GO:0021554 optic nerve development
GO:0031290 retinal ganglion cell axon guidance
GO:0060041 retina development in camera-type eye

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0045202 synapse


-  Descriptions from all associated GenBank mRNAs
  BC070193 - Homo sapiens ribosomal protein L24, mRNA (cDNA clone MGC:88174 IMAGE:6733162), complete cds.
M94314 - Homo sapiens ribosomal protein L30 mRNA, complete cds.
BC000690 - Homo sapiens ribosomal protein L24, mRNA (cDNA clone MGC:2240 IMAGE:3349215), complete cds.
EU668341 - Homo sapiens epididymis secretory protein Li 310 (HEL-S-310) mRNA, complete cds.
KJ892033 - Synthetic construct Homo sapiens clone ccsbBroadEn_01427 RPL24 gene, encodes complete protein.
CR456729 - Homo sapiens full open reading frame cDNA clone RZPDo834E036D for gene RPL24, ribosomal protein L24; complete cds, incl. stopcodon.
AK311992 - Homo sapiens cDNA, FLJ92265, Homo sapiens ribosomal protein L24 (RPL24), mRNA.
DQ892621 - Synthetic construct clone IMAGE:100005251; FLH188387.01X; RZPDo839B1073D ribosomal protein L24 (RPL24) gene, encodes complete protein.
DQ895861 - Synthetic construct Homo sapiens clone IMAGE:100010321; FLH188383.01L; RZPDo839B1063D ribosomal protein L24 (RPL24) gene, encodes complete protein.
JD024479 - Sequence 5503 from Patent EP1572962.
JD029023 - Sequence 10047 from Patent EP1572962.
JD137785 - Sequence 118809 from Patent EP1572962.
LF319864 - JP 2014500723-A/127367: Polycomb-Associated Non-Coding RNAs.
JD024690 - Sequence 5714 from Patent EP1572962.
JD027839 - Sequence 8863 from Patent EP1572962.
JD548653 - Sequence 529677 from Patent EP1572962.
D28400 - Homo sapiens mRNA for ribosomal protein L24, partial cds.
MA555441 - JP 2018138019-A/127367: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000394077.1, ENST00000394077.2, ENST00000394077.3, ENST00000394077.4, ENST00000394077.5, ENST00000394077.6, ENST00000394077.7, NM_000986, uc318wiy.1, V9HW01, V9HW01_HUMAN
UCSC ID: ENST00000394077.8_7
RefSeq Accession: NM_000986
Protein: V9HW01

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.