Human Gene RIOK3 (ENST00000339486.8_5) from GENCODE V45lift37
Description: Homo sapiens RIO kinase 3 (RIOK3), transcript variant 3, non-coding RNA. (from RefSeq NR_145477) RefSeq Summary (NM_003831): This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000339486.8_5 Gencode Gene: ENSG00000101782.15_9 Transcript (Including UTRs) Position: hg19 chr18:21,033,251-21,063,104 Size: 29,854 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr18:21,033,404-21,061,243 Size: 27,840 Coding Exon Count: 13
ID:RIOK3_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase RIO3; EC=2.7.11.1; AltName: Full=RIO kinase 3; AltName: Full=sudD homolog; FUNCTION: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843). CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; SUBUNIT: Interacts with CASP10 (PubMed:19557502). Interacts with IRF3; RIOK3 probably mediates the interaction of TBK1 with IRF3 (PubMed:24807708). Associated with 40S pre-ribosomal particles. INTERACTION: O14730; Q92851: CASP10; NbExp=6; IntAct=EBI-1047061, EBI-495095; O14730; Q92851-7: CASP10; NbExp=3; IntAct=EBI-1047061, EBI-12737837; O14730; Q9BYX4: IFIH1; NbExp=6; IntAct=EBI-1047061, EBI-6115771; O14730; Q14653: IRF3; NbExp=6; IntAct=EBI-1047061, EBI-2650369; O14730; Q9UHD2: TBK1; NbExp=3; IntAct=EBI-1047061, EBI-356402; SUBCELLULAR LOCATION: Cytoplasm TISSUE SPECIFICITY: Widely expressed. PTM: Autophosphorylated (in vitro). SIMILARITY: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14730
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Gene Ontology (GO) Annotations with Structured Vocabulary