Human Gene PTBP3 (ENST00000374257.6_8) from GENCODE V45lift37
Description: Homo sapiens polypyrimidine tract binding protein 3 (PTBP3), transcript variant 7, mRNA. (from RefSeq NM_001375918) RefSeq Summary (NM_001163788): The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000374257.6_8 Gencode Gene: ENSG00000119314.16_12 Transcript (Including UTRs) Position: hg19 chr9:114,980,715-115,095,899 Size: 115,185 Total Exon Count: 14 Strand: - Coding Region Position: hg19 chr9:114,986,131-115,060,145 Size: 74,015 Coding Exon Count: 13
ID:PTBP3_HUMAN DESCRIPTION: RecName: Full=Polypyrimidine tract-binding protein 3; AltName: Full=Regulator of differentiation 1; Short=Rod1; FUNCTION: RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U). SUBUNIT: Interacts with THBS4 (via the acidic amphipathic C-terminus). TISSUE SPECIFICITY: Expressed in several hematopoietic cell lines examined. SEQUENCE CAUTION: Sequence=AAH39896.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence=; Sequence=BAA75466.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=; Sequence=BI463123; Type=Frameshift; Evidence=;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF13893 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PF11835 - Domain of unknown function (DUF3355)
ModBase Predicted Comparative 3D Structure on O95758
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Gene Ontology (GO) Annotations with Structured Vocabulary