Human Gene PLCXD1 (ENST00000381657.8_7) from GENCODE V45lift37
  Description: Homo sapiens phosphatidylinositol specific phospholipase C X domain containing 1 (PLCXD1), transcript variant 7, non-coding RNA. (from RefSeq NR_163416)
RefSeq Summary (NM_018390): This gene is the most terminal protein-coding gene in the pseudoautosomal (PAR) region on chromosomes X and Y. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Gencode Transcript: ENST00000381657.8_7
Gencode Gene: ENSG00000182378.15_11
Transcript (Including UTRs)
   Position: hg19 chrX:198,048-220,023 Size: 21,976 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chrX:200,855-216,002 Size: 15,148 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2024-04-24 11:59:55

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:198,048-220,023)mRNA (may differ from genome)Protein (323 aa)
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-  Comments and Description Text from UniProtKB
  ID: PLCX1_HUMAN
DESCRIPTION: RecName: Full=PI-PLC X domain-containing protein 1;
SUBCELLULAR LOCATION: Cytoplasm
TISSUE SPECIFICITY: Widely expressed.
MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.75 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 210.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -118.40325-0.364 Picture PostScript Text
3' UTR -1969.804021-0.490 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017946 - PLC-like_Pdiesterase_TIM-brl
IPR042158 - PLCXD1/2/3
IPR000909 - PLipase_C_PInositol-sp_X_dom

Pfam Domains:
PF00388 - Phosphatidylinositol-specific phospholipase C, X domain

ModBase Predicted Comparative 3D Structure on Q9NUJ7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008081 phosphoric diester hydrolase activity

Biological Process:
GO:0006629 lipid metabolic process

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK002185 - Homo sapiens cDNA FLJ11323 fis, clone PLACE1010362, weakly similar to 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE PRECURSOR (EC 3.1.4.10).
BC064136 - Homo sapiens phosphatidylinositol-specific phospholipase C, X domain containing 1, mRNA (cDNA clone IMAGE:6526328).
BC005028 - Homo sapiens phosphatidylinositol-specific phospholipase C, X domain containing 1, mRNA (cDNA clone MGC:12582 IMAGE:3953383), complete cds.
BC000888 - Homo sapiens phosphatidylinositol-specific phospholipase C, X domain containing 1, mRNA (cDNA clone IMAGE:3462893).
BC032072 - Homo sapiens phosphatidylinositol-specific phospholipase C, X domain containing 1, mRNA (cDNA clone IMAGE:3462894).
JD476599 - Sequence 457623 from Patent EP1572962.
JD439212 - Sequence 420236 from Patent EP1572962.
JD399984 - Sequence 381008 from Patent EP1572962.
CU678870 - Synthetic construct Homo sapiens gateway clone IMAGE:100018918 5' read PLCXD1 mRNA.
KJ899133 - Synthetic construct Homo sapiens clone ccsbBroadEn_08527 PLCXD1 gene, encodes complete protein.
HQ447796 - Synthetic construct Homo sapiens clone IMAGE:100071139; CCSB005097_01 phosphatidylinositol-specific phospholipase C, X domain containing 1 (PLCXD1) gene, encodes complete protein.
JD532536 - Sequence 513560 from Patent EP1572962.
JD158399 - Sequence 139423 from Patent EP1572962.
JD152709 - Sequence 133733 from Patent EP1572962.
JD282104 - Sequence 263128 from Patent EP1572962.
JD224742 - Sequence 205766 from Patent EP1572962.
JD407851 - Sequence 388875 from Patent EP1572962.
JD181976 - Sequence 163000 from Patent EP1572962.
JD441506 - Sequence 422530 from Patent EP1572962.
DL492017 - Novel nucleic acids.
DL490569 - Novel nucleic acids.
JD258190 - Sequence 239214 from Patent EP1572962.
JD536553 - Sequence 517577 from Patent EP1572962.
JD459836 - Sequence 440860 from Patent EP1572962.
JD131536 - Sequence 112560 from Patent EP1572962.
JD413476 - Sequence 394500 from Patent EP1572962.
JD247065 - Sequence 228089 from Patent EP1572962.
JD247066 - Sequence 228090 from Patent EP1572962.
JD194942 - Sequence 175966 from Patent EP1572962.
JD136322 - Sequence 117346 from Patent EP1572962.
JD280822 - Sequence 261846 from Patent EP1572962.
AK091006 - Homo sapiens cDNA FLJ33687 fis, clone BRAWH2002725.
AX746727 - Sequence 252 from Patent EP1308459.
JD397055 - Sequence 378079 from Patent EP1572962.
JD414836 - Sequence 395860 from Patent EP1572962.
JD415715 - Sequence 396739 from Patent EP1572962.
JD252881 - Sequence 233905 from Patent EP1572962.
JD094127 - Sequence 75151 from Patent EP1572962.
JD429094 - Sequence 410118 from Patent EP1572962.
JD311817 - Sequence 292841 from Patent EP1572962.
JD311818 - Sequence 292842 from Patent EP1572962.
DQ586065 - Homo sapiens piRNA piR-53177, complete sequence.
AK097346 - Homo sapiens cDNA FLJ40027 fis, clone STOMA2008614.
BC033659 - Homo sapiens phosphatidylinositol-specific phospholipase C, X domain containing 1, mRNA (cDNA clone IMAGE:4394596), containing frame-shift errors.
JD476733 - Sequence 457757 from Patent EP1572962.
JD414834 - Sequence 395858 from Patent EP1572962.
JD311809 - Sequence 292833 from Patent EP1572962.
JD311810 - Sequence 292834 from Patent EP1572962.
JD081610 - Sequence 62634 from Patent EP1572962.
JD181043 - Sequence 162067 from Patent EP1572962.
JD081611 - Sequence 62635 from Patent EP1572962.
JD465278 - Sequence 446302 from Patent EP1572962.
JD418709 - Sequence 399733 from Patent EP1572962.
JD258978 - Sequence 240002 from Patent EP1572962.
JD257895 - Sequence 238919 from Patent EP1572962.
JD293690 - Sequence 274714 from Patent EP1572962.
JD465943 - Sequence 446967 from Patent EP1572962.
JD409332 - Sequence 390356 from Patent EP1572962.
JD256549 - Sequence 237573 from Patent EP1572962.
JD476735 - Sequence 457759 from Patent EP1572962.
JD520380 - Sequence 501404 from Patent EP1572962.
JD406295 - Sequence 387319 from Patent EP1572962.
JD557993 - Sequence 539017 from Patent EP1572962.
JD172891 - Sequence 153915 from Patent EP1572962.
JD376640 - Sequence 357664 from Patent EP1572962.
JD414838 - Sequence 395862 from Patent EP1572962.
JD414837 - Sequence 395861 from Patent EP1572962.
JD379689 - Sequence 360713 from Patent EP1572962.
JD311819 - Sequence 292843 from Patent EP1572962.
JD311820 - Sequence 292844 from Patent EP1572962.
JD081616 - Sequence 62640 from Patent EP1572962.
JD512120 - Sequence 493144 from Patent EP1572962.
JD348208 - Sequence 329232 from Patent EP1572962.
JD129567 - Sequence 110591 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2BH51, A2BH52, ENST00000381657.1, ENST00000381657.2, ENST00000381657.3, ENST00000381657.4, ENST00000381657.5, ENST00000381657.6, ENST00000381657.7, NR_163416, PLCX1_HUMAN, Q9NUJ7, uc318qka.1
UCSC ID: ENST00000381657.8_7
RefSeq Accession: NM_018390
Protein: Q9NUJ7 (aka PLCX1_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.