Human Gene PBXIP1 (ENST00000368463.8_13) from GENCODE V45lift37
Description: Homo sapiens PBX homeobox interacting protein 1 (PBXIP1), transcript variant 1, mRNA. (from RefSeq NM_020524)
RefSeq Summary (NM_020524): The protein encoded by this gene interacts with the PBX1 homeodomain protein, inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein, which is primarily cytosolic but can shuttle to the nucleus, also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer, brain tumors, and lung cancer. Several transcript variants encoding different isoforms have been found for this gene. More variants exist, but their full-length natures have yet to be determined. [provided by RefSeq, Dec 2015].
Gencode Transcript: ENST00000368463.8_13
Gencode Gene: ENSG00000163346.17_15
Transcript (Including UTRs)
Position: hg19 chr1:154,916,556-154,928,575 Size: 12,020 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr1:154,917,500-154,926,197 Size: 8,698 Coding Exon Count: 10
Data last updated at UCSC: 2024-04-24 11:59:55
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PBIP1_HUMAN
DESCRIPTION: RecName: Full=Pre-B-cell leukemia transcription factor-interacting protein 1; AltName: Full=Hematopoietic PBX-interacting protein;
FUNCTION: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.SUBUNIT: Interacts with TEX11 (By similarity). Interacts with ESR1, PBX1, PBX2 and PBX3.INTERACTION: Q96AQ6; P49069: CAMLG; NbExp=3; IntAct=EBI-740845, EBI-1748958; Q96AQ6; P24863: CCNC; NbExp=3; IntAct=EBI-740845, EBI-395261; Q96AQ6; Q9UER7: DAXX; NbExp=3; IntAct=EBI-740845, EBI-77321; Q96AQ6; Q9H4E7: DEF6; NbExp=3; IntAct=EBI-740845, EBI-745369; Q96AQ6; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-740845, EBI-10172181; Q96AQ6; Q9H0R8: GABARAPL1; NbExp=3; IntAct=EBI-740845, EBI-746969; Q96AQ6; Q96IK5: GMCL1; NbExp=5; IntAct=EBI-740845, EBI-2548508; Q96AQ6; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-740845, EBI-12012928; Q96AQ6; O95447: LCA5L; NbExp=3; IntAct=EBI-740845, EBI-8473670; Q96AQ6; Q99750: MDFI; NbExp=4; IntAct=EBI-740845, EBI-724076; Q96AQ6; Q9UBU8: MORF4L1; NbExp=3; IntAct=EBI-740845, EBI-399246; Q96AQ6; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-740845, EBI-10288852; Q96AQ6; Q8NI37: PPTC7; NbExp=3; IntAct=EBI-740845, EBI-9089276; Q96AQ6; O43765: SGTA; NbExp=4; IntAct=EBI-740845, EBI-347996; Q96AQ6; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-740845, EBI-10173939; Q96AQ6; Q9Y3C0: WASHC3; NbExp=4; IntAct=EBI-740845, EBI-712969; Q96AQ6-1; P03372: ESR1; NbExp=3; IntAct=EBI-15606280, EBI-78473; Q96AQ6-1; P03372-1: ESR1; NbExp=5; IntAct=EBI-15606280, EBI-15606245;SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton Nucleus Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).TISSUE SPECIFICITY: Expressed in early hematopoietic precursors.DOMAIN: The C-terminal domain (AA 443-731) contains a nuclear export signal.DOMAIN: Association to the cytoskeleton through a N-terminal leucine rich-domain (AA 190-218).
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: PBXIP1
Diseases sorted by gene-association score: leukemia (7)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q96AQ6
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Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF206189 - JP 2014500723-A/13692: Polycomb-Associated Non-Coding RNAs.AK022497 - Homo sapiens cDNA FLJ12435 fis, clone NT2RM1000059.BC016852 - Homo sapiens pre-B-cell leukemia homeobox interacting protein 1, mRNA (cDNA clone MGC:16853 IMAGE:3900461), complete cds.AK023219 - Homo sapiens cDNA FLJ13157 fis, clone NT2RP3003543.AK303863 - Homo sapiens cDNA FLJ58464 complete cds, highly similar to Homo sapiens pre-B-cell leukemia transcription factor interacting protein 1 (PBXIP1), mRNA.AK300987 - Homo sapiens cDNA FLJ58285 complete cds, highly similar to Homo sapiens pre-B-cell leukemia transcription factor interacting protein 1 (PBXIP1), mRNA.AF221521 - Homo sapiens hematopoietic PBX-interacting protein mRNA, complete cds.AK303413 - Homo sapiens cDNA FLJ58659 complete cds, highly similar to Homo sapiens pre-B-cell leukemia transcription factor interacting protein 1 (PBXIP1), mRNA.AK315551 - Homo sapiens cDNA, FLJ96621.AK300544 - Homo sapiens cDNA FLJ57088 complete cds, highly similar to Homo sapiens pre-B-cell leukemia transcription factor interacting protein 1 (PBXIP1), mRNA.AK310712 - Homo sapiens cDNA, FLJ17754.AK310388 - Homo sapiens cDNA, FLJ17430.MA441766 - JP 2018138019-A/13692: Polycomb-Associated Non-Coding RNAs.JD245993 - Sequence 227017 from Patent EP1572962.JD181272 - Sequence 162296 from Patent EP1572962.JD437120 - Sequence 418144 from Patent EP1572962.JD293602 - Sequence 274626 from Patent EP1572962.JD437724 - Sequence 418748 from Patent EP1572962.JD321870 - Sequence 302894 from Patent EP1572962.JD164632 - Sequence 145656 from Patent EP1572962.JD155343 - Sequence 136367 from Patent EP1572962.JD548812 - Sequence 529836 from Patent EP1572962.JD283053 - Sequence 264077 from Patent EP1572962.U00952 - Human clone A9A2BRB7 (CAC)n/(GTG)n repeat-containing mRNA.JD459264 - Sequence 440288 from Patent EP1572962.JD513315 - Sequence 494339 from Patent EP1572962.JD195553 - Sequence 176577 from Patent EP1572962.JD366022 - Sequence 347046 from Patent EP1572962.KJ894418 - Synthetic construct Homo sapiens clone ccsbBroadEn_03812 PBXIP1 gene, encodes complete protein.EU446600 - Synthetic construct Homo sapiens clone IMAGE:100070184; IMAGE:100011809; FLH257361.01L pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1) gene, encodes complete protein.AB385237 - Synthetic construct DNA, clone: pF1KB9479, Homo sapiens PBXIP1 gene for pre-B-cell leukemia homeobox interacting protein 1, complete cds, without stop codon, in Flexi system.LF352275 - JP 2014500723-A/159778: Polycomb-Associated Non-Coding RNAs.LF352272 - JP 2014500723-A/159775: Polycomb-Associated Non-Coding RNAs.LF352271 - JP 2014500723-A/159774: Polycomb-Associated Non-Coding RNAs.JD020749 - Sequence 1773 from Patent EP1572962.BC127909 - Homo sapiens cDNA clone IMAGE:40132872, partial cds.BC127910 - Homo sapiens cDNA clone IMAGE:40132874, partial cds.LF352270 - JP 2014500723-A/159773: Polycomb-Associated Non-Coding RNAs.LF352268 - JP 2014500723-A/159771: Polycomb-Associated Non-Coding RNAs.LF352267 - JP 2014500723-A/159770: Polycomb-Associated Non-Coding RNAs.LF352266 - JP 2014500723-A/159769: Polycomb-Associated Non-Coding RNAs.LF352263 - JP 2014500723-A/159766: Polycomb-Associated Non-Coding RNAs.CU677741 - Synthetic construct Homo sapiens gateway clone IMAGE:100017471 5' read PBXIP1 mRNA.LF352262 - JP 2014500723-A/159765: Polycomb-Associated Non-Coding RNAs.LF352261 - JP 2014500723-A/159764: Polycomb-Associated Non-Coding RNAs.LF352260 - JP 2014500723-A/159763: Polycomb-Associated Non-Coding RNAs.LF352259 - JP 2014500723-A/159762: Polycomb-Associated Non-Coding RNAs.LF352258 - JP 2014500723-A/159761: Polycomb-Associated Non-Coding RNAs.LF352253 - JP 2014500723-A/159756: Polycomb-Associated Non-Coding RNAs.JD203369 - Sequence 184393 from Patent EP1572962.MA587852 - JP 2018138019-A/159778: Polycomb-Associated Non-Coding RNAs.MA587849 - JP 2018138019-A/159775: Polycomb-Associated Non-Coding RNAs.MA587848 - JP 2018138019-A/159774: Polycomb-Associated Non-Coding RNAs.MA587847 - JP 2018138019-A/159773: Polycomb-Associated Non-Coding RNAs.MA587845 - JP 2018138019-A/159771: Polycomb-Associated Non-Coding RNAs.MA587844 - JP 2018138019-A/159770: Polycomb-Associated Non-Coding RNAs.MA587843 - JP 2018138019-A/159769: Polycomb-Associated Non-Coding RNAs.MA587840 - JP 2018138019-A/159766: Polycomb-Associated Non-Coding RNAs.MA587839 - JP 2018138019-A/159765: Polycomb-Associated Non-Coding RNAs.MA587838 - JP 2018138019-A/159764: Polycomb-Associated Non-Coding RNAs.MA587837 - JP 2018138019-A/159763: Polycomb-Associated Non-Coding RNAs.MA587836 - JP 2018138019-A/159762: Polycomb-Associated Non-Coding RNAs.MA587835 - JP 2018138019-A/159761: Polycomb-Associated Non-Coding RNAs.MA587830 - JP 2018138019-A/159756: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: ENST00000368463.1, ENST00000368463.2, ENST00000368463.3, ENST00000368463.4, ENST00000368463.5, ENST00000368463.6, ENST00000368463.7, HPIP, NM_020524, PBIP1_HUMAN, Q5T174, Q5T176, Q96AQ6, Q9H8X6, Q9HA02, Q9HD85, uc318guf.1UCSC ID: ENST00000368463.8_13RefSeq Accession: NM_020524
Protein: Q96AQ6
(aka PBIP1_HUMAN)
Methods, Credits, and Use Restrictions
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