Human Gene MNT (ENST00000174618.5_6) from GENCODE V45lift37
Description: Homo sapiens MAX network transcriptional repressor (MNT), mRNA. (from RefSeq NM_020310) RefSeq Summary (NM_020310): The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000174618.5_6 Gencode Gene: ENSG00000070444.15_8 Transcript (Including UTRs) Position: hg19 chr17:2,287,367-2,304,354 Size: 16,988 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr17:2,290,195-2,304,006 Size: 13,812 Coding Exon Count: 6
ID:MNT_HUMAN DESCRIPTION: RecName: Full=Max-binding protein MNT; AltName: Full=Class D basic helix-loop-helix protein 3; Short=bHLHd3; AltName: Full=Myc antagonist MNT; AltName: Full=Protein ROX; FUNCTION: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX. INTERACTION: Q99583; P61244: MAX; NbExp=8; IntAct=EBI-7959025, EBI-751711; Q99583; Q99583: MNT; NbExp=2; IntAct=EBI-7959025, EBI-7959025; Q99583; O43639: NCK2; NbExp=3; IntAct=EBI-7959025, EBI-713635; Q99583; Q60520: Sin3a; Xeno; NbExp=3; IntAct=EBI-7959025, EBI-349034; SUBCELLULAR LOCATION: Nucleus.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99583
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Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0046983 protein dimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0007569 cell aging GO:0008285 negative regulation of cell proliferation GO:0051726 regulation of cell cycle GO:1903508 positive regulation of nucleic acid-templated transcription GO:2001234 negative regulation of apoptotic signaling pathway