Human Gene LYN (ENST00000519728.6_9) from GENCODE V45lift37

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ID: LYN_HUMAN
DESCRIPTION: RecName: Full=Tyrosine-protein kinase Lyn; EC=2.7.10.2; AltName: Full=Lck/Yes-related novel protein tyrosine kinase; AltName: Full=V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; AltName: Full=p53Lyn; AltName: Full=p56Lyn;
FUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3- kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138).
CATALYTIC ACTIVITY: Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=
ACTIVITY REGULATION: Subject to autoinhibition, mediated by intramolecular interactions between the SH2 domain and the C-terminal phosphotyrosine. Phosphorylation at Tyr-397 is required for optimal activity. Phosphorylated by CSK at Tyr-508; phosphorylation at Tyr-508 inhibits kinase activity. Kinase activity is modulated by dephosphorylation by PTPRC/CD45. Inhibited by Dasatinib, PP2, and SU6656.
SUBUNIT: Interacts with TEC. Interacts (via SH2 domain) with FLT3 (tyrosine phosphorylated). Interacts with LIME1 and with CD79A upon activation of the B-cell antigen receptor. Interacts with the B-cell receptor complex. Interacts with phosphorylated THEMIS2. Interacts with EPOR. Interacts with MS4A2/FCER1B. Interaction (via the SH2 and SH3 domains) with MUC1 is stimulated by IL7 and the subsequent phosphorylation increases the binding between MUC1 and CTNNB1/beta- catenin. Interacts with ADAM15. Interacts with NDFIP2 and more weakly with NDFIP1. Interacts with FASLG. Interacts with KIT. Interacts with HCLS1. Interacts with FCGR2B. Interacts with FCGR1A; the interaction may be indirect. Interacts with CD19, CD22, CD79A and CD79B. Interacts (via SH3 domain) with CBLC, PPP1R15A and PDE4A. Interacts with TGFB1I1. Interacts (via SH3 domain) with PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase; this interaction enhances phosphatidylinositol 3-kinase activity. Interacts with CSF2RB, the common subunit of the IL3, IL5 and CSF2 receptors. Interacts with PAG1; identified in a complex with PAG1 and STAT3. Interacts with ABL1. Interacts with PTPN6/SHP-1. Interacts (via SH3 domain) with SCIMP (via proline-rich region) (PubMed:21930792). This interaction facilitates the phosphorylation of SCIMP on 'Tyr-107', which enhances binding of SCIMP to TLR4, and consequently the phosphorylation of TLR4 in response to stimulation by lipopolysaccharide in macrophages (By similarity). Interacts with LPXN (via LD motif 3) and the interaction is induced upon B-cell antigen receptor (BCR) activation. Interacts (via SH3- domain) with ANKRD54 (via ankyrin repeat region) in an activation- independent status of LYN. Forms a multiprotein complex with ANKRD54 and HCLS1. Interacts (via SH2 and SH3 domains) with UNC119; leading to LYN activation. Interacts with CD36. Interacts with LYN (By similarity). Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (By similarity). Interacts with BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138).
SUBUNIT: (Microbial infection) Interacts with Epstein-Barr virus LMP2A.
SUBUNIT: (Microbial infection) Interacts with Herpes virus saimiri tyrosine kinase interacting protein (Tip).
INTERACTION: P07948; P01023: A2M; NbExp=3; IntAct=EBI-79452, EBI-640741; P07948; O43184: ADAM12; NbExp=2; IntAct=EBI-79452, EBI-2625825; P07948; Q13444: ADAM15; NbExp=2; IntAct=EBI-79452, EBI-77818; P07948; P05067: APP; NbExp=3; IntAct=EBI-79452, EBI-77613; P07948; P10275: AR; NbExp=5; IntAct=EBI-79452, EBI-608057; P07948; Q8NDB2: BANK1; NbExp=3; IntAct=EBI-79452, EBI-2837677; P07948; Q96GW7: BCAN; NbExp=3; IntAct=EBI-79452, EBI-2690445; P07948; P20273: CD22; NbExp=2; IntAct=EBI-79452, EBI-78277; P07948; P25063: CD24; NbExp=6; IntAct=EBI-79452, EBI-6267018; P07948; P16671: CD36; NbExp=3; IntAct=EBI-79452, EBI-2808214; P07948; P11049: CD37; NbExp=5; IntAct=EBI-79452, EBI-6139068; P07948; P46527: CDKN1B; NbExp=2; IntAct=EBI-79452, EBI-519280; P07948; P50570-2: DNM2; NbExp=3; IntAct=EBI-79452, EBI-10968534; P07948; P00533: EGFR; NbExp=7; IntAct=EBI-79452, EBI-297353; P07948; Q9BS26: ERP44; NbExp=3; IntAct=EBI-79452, EBI-541644; P07948; Q13480: GAB1; NbExp=7; IntAct=EBI-79452, EBI-517684; P07948; Q9HCN6: GP6; NbExp=5; IntAct=EBI-79452, EBI-515278; P07948; Q9HCN6-1: GP6; NbExp=2; IntAct=EBI-79452, EBI-15816577; P07948; P08238: HSP90AB1; NbExp=2; IntAct=EBI-79452, EBI-352572; P07948; P05556: ITGB1; NbExp=4; IntAct=EBI-79452, EBI-703066; P07948; P10721: KIT; NbExp=7; IntAct=EBI-79452, EBI-1379503; P07948; Q96L34: MARK4; NbExp=3; IntAct=EBI-79452, EBI-302319; P07948; P33993: MCM7; NbExp=4; IntAct=EBI-79452, EBI-355924; P07948; P51608: MECP2; NbExp=3; IntAct=EBI-79452, EBI-1189067; P07948; P08581: MET; NbExp=2; IntAct=EBI-79452, EBI-1039152; P07948; Q9NWQ8: PAG1; NbExp=16; IntAct=EBI-79452, EBI-2828115; P07948; P27986-2: PIK3R1; NbExp=3; IntAct=EBI-79452, EBI-9090282; P07948; P07602: PSAP; NbExp=3; IntAct=EBI-79452, EBI-716699; P07948; P63244: RACK1; NbExp=2; IntAct=EBI-79452, EBI-296739; P07948; Q6UWF3: SCIMP; NbExp=3; IntAct=EBI-79452, EBI-2872510; P07948; P37840: SNCA; NbExp=3; IntAct=EBI-79452, EBI-985879; P07948; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-79452, EBI-5235340; P07948; P12931: SRC; NbExp=4; IntAct=EBI-79452, EBI-621482; P07948; Q8R5G7: Arap3; Xeno; NbExp=2; IntAct=EBI-79452, EBI-621463; P07948; Q08857: Cd36; Xeno; NbExp=2; IntAct=EBI-79452, EBI-8346984; P07948; O92972; Xeno; NbExp=2; IntAct=EBI-79452, EBI-710506; P07948; P22575; Xeno; NbExp=3; IntAct=EBI-79452, EBI-866709; P07948; P27958; Xeno; NbExp=4; IntAct=EBI-79452, EBI-706378; P07948; Q9WMX2; Xeno; NbExp=3; IntAct=EBI-79452, EBI-710918; P07948-1; P00533: EGFR; NbExp=2; IntAct=EBI-6895930, EBI-297353; P07948-1; P33993: MCM7; NbExp=5; IntAct=EBI-6895930, EBI-355924;
SUBCELLULAR LOCATION: Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane ; Lipid- anchor Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts.
TISSUE SPECIFICITY: Detected in monocytes (at protein level). Detected in placenta, and in fetal brain, lung, liver and kidney. Widely expressed in a variety of organs, tissues, and cell types such as epidermoid, hematopoietic, and neuronal cells. Expressed in primary neuroblastoma tumors.
DOMAIN: The protein kinase domain plays an important role in its localization in the cell membrane.
PTM: Ubiquitinated by CBL, leading to its degradation. Ubiquitination is SH3-dependent.
PTM: Autophosphorylated (PubMed:7935444, PubMed:9171348, PubMed:9341198, PubMed:18056483, PubMed:18070987). Phosphorylated on tyrosine residues in response to KIT signaling (PubMed:9341198). Phosphorylation at Tyr-397 is required for optimal activity (PubMed:16920712). Phosphorylation at Tyr-508 inhibits kinase activity (PubMed:9171348). Phosphorylated at Tyr-508 by CSK (PubMed:7935444). Dephosphorylated by PTPRC/CD45 (By similarity). Becomes rapidly phosphorylated upon activation of the B-cell receptor and the immunoglobulin receptor FCGR1A (PubMed:8064233). Phosphorylated in response to ITGB1 in B-cells (PubMed:9020138).
DISEASE: Note=Constitutively phosphorylated and activated in cells from a number of chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) patients. Mediates phosphorylation of the BCR-ABL fusion protein. Abnormally elevated expression levels or activation of LYN signaling may play a role in survival and proliferation of some types of cancer cells.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

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MalaCards Gene Search: LYN
Diseases sorted by gene-association score: sarcoma (28), hantavirus pulmonary syndrome (12), spherocytosis, type 1 (8), leukemia, chronic myeloid, somatic (7), megakaryocytic leukemia (5), chronic lymphocytic leukemia (2), neuroblastoma (2), hereditary spherocytosis (1)

The following chemicals interact with this gene

D013749 Tetrachlorodibenzodioxin
C027576 4-hydroxy-2-nonenal
D003907 Dexamethasone
D004997 Ethinyl Estradiol
C488369 dasatinib
C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
C021296 2-ethoxyethanol
C023035 3,4,5,3',4'-pentachlorobiphenyl
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
C412373 AG 1879

more ... click here to view the complete list

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Highest median expression: 118.09 RPKM in Whole Blood
Total median expression: 506.62 RPKM

View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

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Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0043015 gamma-tubulin binding
GO:0043208 glycosphingolipid binding
GO:0044325 ion channel binding
GO:0044877 macromolecular complex binding
GO:0046875 ephrin receptor binding
GO:0051219 phosphoprotein binding

Biological Process:
GO:0001782 B cell homeostasis
GO:0001817 regulation of cytokine production
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002376 immune system process
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002513 tolerance induction to self antigen
GO:0002553 histamine secretion by mast cell
GO:0002576 platelet degranulation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002774 Fc receptor mediated inhibitory signaling pathway
GO:0002902 regulation of B cell apoptotic process
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0006974 cellular response to DNA damage stimulus
GO:0006991 response to sterol depletion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0009743 response to carbohydrate
GO:0010976 positive regulation of neuron projection development
GO:0014003 oligodendrocyte development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030889 negative regulation of B cell proliferation
GO:0031175 neuron projection development
GO:0031295 T cell costimulation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0032868 response to insulin
GO:0033003 regulation of mast cell activation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034605 cellular response to heat
GO:0035556 intracellular signal transduction
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042127 regulation of cell proliferation
GO:0042327 positive regulation of phosphorylation
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043200 response to amino acid
GO:0043304 regulation of mast cell degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0043434 response to peptide hormone
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045646 regulation of erythrocyte differentiation
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0048678 response to axon injury
GO:0050663 cytokine secretion
GO:0050707 regulation of cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050777 negative regulation of immune response
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051272 positive regulation of cellular component movement
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0060252 positive regulation of glial cell proliferation
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation
GO:0070667 negative regulation of mast cell proliferation
GO:0070668 positive regulation of mast cell proliferation
GO:0071300 cellular response to retinoic acid
GO:0090025 regulation of monocyte chemotaxis
GO:0090330 regulation of platelet aggregation
GO:0097028 dendritic cell differentiation
GO:1902532 negative regulation of intracellular signal transduction
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:2000670 positive regulation of dendritic cell apoptotic process

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030061 mitochondrial crista
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031966 mitochondrial membrane
GO:0034666 integrin alpha2-beta1 complex
GO:0042629 mast cell granule
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0098978 glutamatergic synapse
GO:0099091 postsynaptic specialization, intracellular component

M16038 - Human lyn mRNA encoding a tyrosine kinase.
BC126456 - Homo sapiens v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, mRNA (cDNA clone MGC:161734 IMAGE:8992172), complete cds.
BC126458 - Homo sapiens v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, mRNA (cDNA clone MGC:161736 IMAGE:8992174), complete cds.
BC059394 - Homo sapiens v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, mRNA (cDNA clone IMAGE:30332044), partial cds.
BC068551 - Homo sapiens v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, mRNA (cDNA clone IMAGE:30334379), partial cds.
AK290494 - Homo sapiens cDNA FLJ75641 complete cds, highly similar to Homo sapiens v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (LYN), mRNA.
BC075001 - Homo sapiens v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, mRNA (cDNA clone MGC:103991 IMAGE:30915399), complete cds.
BC075002 - Homo sapiens v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, mRNA (cDNA clone MGC:104151 IMAGE:30915611), complete cds.
M79321 - Human Lyn B protein mRNA, complete cds.
AB527528 - Synthetic construct DNA, clone: pF1KB5955, Homo sapiens LYN gene for v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, without stop codon, in Flexi system.
HQ258300 - Synthetic construct Homo sapiens clone IMAGE:100072609 Unknown protein gene, encodes complete protein.
KJ891560 - Synthetic construct Homo sapiens clone ccsbBroadEn_00954 LYN gene, encodes complete protein.
KJ897152 - Synthetic construct Homo sapiens clone ccsbBroadEn_06546 LYN gene, encodes complete protein.
AK298677 - Homo sapiens cDNA FLJ56471 complete cds, highly similar to Tyrosine-protein kinase Lyn (EC 2.7.10.2).
AK130135 - Homo sapiens cDNA FLJ26625 fis, clone MPC03823, highly similar to Tyrosine-protein kinase LYN (EC 2.7.1.112).
JD460338 - Sequence 441362 from Patent EP1572962.
JD382310 - Sequence 363334 from Patent EP1572962.
JD103353 - Sequence 84377 from Patent EP1572962.
JD057362 - Sequence 38386 from Patent EP1572962.
JD405340 - Sequence 386364 from Patent EP1572962.
JD083678 - Sequence 64702 from Patent EP1572962.
JD493559 - Sequence 474583 from Patent EP1572962.
JD560454 - Sequence 541478 from Patent EP1572962.
JD447626 - Sequence 428650 from Patent EP1572962.
JD292270 - Sequence 273294 from Patent EP1572962.
JD248588 - Sequence 229612 from Patent EP1572962.
JD424477 - Sequence 405501 from Patent EP1572962.
JD352328 - Sequence 333352 from Patent EP1572962.
JD358389 - Sequence 339413 from Patent EP1572962.
JD326905 - Sequence 307929 from Patent EP1572962.
JD430901 - Sequence 411925 from Patent EP1572962.
JD558719 - Sequence 539743 from Patent EP1572962.
JD442894 - Sequence 423918 from Patent EP1572962.
JD335279 - Sequence 316303 from Patent EP1572962.
JD335280 - Sequence 316304 from Patent EP1572962.
JD254675 - Sequence 235699 from Patent EP1572962.

Reactome (by CSHL, EBI, and GO)

Protein P07948 (Reactome details) participates in the following event(s):

R-HSA-2730862 Autophosphorylation of LYN kinase
R-HSA-432295 GPVI binds Fyn and Lyn
R-HSA-1168456 Growth hormone receptor binds Lyn
R-HSA-2454208 Phosphorylation of beta and gamma subunits by LYN
R-HSA-5690702 LYN phosphorylates CD22
R-HSA-114577 Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen
R-HSA-205205 Interaction of Src family kinases with p-KIT
R-HSA-388833 Phosphorylation of CTLA-4
R-HSA-3928584 p-EPHs bind SRC,FYN,YES,LYN
R-HSA-879917 CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
R-HSA-114600 Fyn/Lyn-mediated phosphorylation of FcR1 gamma
R-HSA-139842 Binding of Syk tyrosine kinase
R-HSA-453183 p-Y348-SYK dissociates
R-HSA-205238 SHP2 interacts with p-KIT
R-HSA-205319 Interaction of APS and p-KIT
R-HSA-1433451 JAK2 binds to p-KIT
R-HSA-1472121 Phosphorylation of p-KIT on Y900 by Src kinases
R-HSA-388829 SHP2 phosphatase binds CTLA-4
R-HSA-210291 Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src
R-HSA-388831 Phosphorylation of CD28
R-HSA-3928623 EPHBs bind NMDARs
R-HSA-3928607 p-EPHs bind VAV2,3
R-HSA-3928602 NGEF binds EPHA
R-HSA-4093327 EPHA binds TIAM1
R-HSA-5621355 LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG
R-HSA-912629 CBL is tyrosine phosphorylated
R-HSA-2454240 Recruitment of SYK to p-FCERI gamma subunit
R-HSA-8942607 Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
R-HSA-453200 SYK autophosphorylates
R-HSA-1433506 Phosphorylation of APS
R-HSA-1433488 Phosphorylation of SHP2 by SFKs
R-HSA-1433418 Phosphorylation of JAK2
R-HSA-1433456 Recruitment of STATs
R-HSA-1433428 GRB2 is indirectly recruited to p-KIT through SHP2
R-HSA-1470012 Disassociation and translocation of STATs to the nucleus
R-HSA-1470010 Dimerization of STATs
R-HSA-1433542 Phosphorylation and activation of VAV1
R-HSA-3928645 EPHB:NMDAR binds TIAM1
R-HSA-3928583 FYN phosphorylates NMDAR2B
R-HSA-3928604 SFKs phosphorylate VAV2,3
R-HSA-3928648 SFKs phosphorylate NGEF
R-HSA-2454239 Phosphorylation of SYK
R-HSA-2730882 Phosphorylation of PKC-theta
R-HSA-205244 Recruitment of CBL to KIT
R-HSA-205234 Indirect recruitment of GAB2 to p-KIT
R-HSA-3928627 EPHB phosphorylates TIAM1
R-HSA-3928628 VAV exchanges GTP for GDP on RAC1, activating it
R-HSA-3928642 TIAM1 exchanges GTP for GDP on RAC1, activating it
R-HSA-3928651 NGEF exchanges GTP for GDP on RHOA
R-HSA-2730833 Phosphorylation of TEC kinases by p-SYK
R-HSA-2730843 Phosphorylation of LAT by p-SYK
R-HSA-2730851 Phosphorylation of SLP-76 by p-SYK
R-HSA-2730884 Phosphorylation of NTAL by p-SYK/Lyn
R-HSA-2730886 Phosphorylation of SHC by SYK kinase
R-HSA-1562641 Indirect recruitment of PI3K to KIT via p(Y)-GAB2
R-HSA-4093336 p-TIAM1 exchanges GTP for GDP on RAC1, activating it
R-HSA-2730860 Phosphorylation of GAB2 by SYK/FYN
R-HSA-2730888 Phosphorylation of PLC-gamma
R-HSA-1433514 Synthesis of PIP3 from PIP2 by PI3K
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-982772 Growth hormone receptor signaling
R-HSA-168249 Innate Immune System
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-912631 Regulation of signaling by CBL
R-HSA-109582 Hemostasis
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-1433559 Regulation of KIT signaling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-388841 Costimulation by the CD28 family
R-HSA-210990 PECAM1 interactions
R-HSA-389356 CD28 co-stimulation
R-HSA-2029481 FCGR activation
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-422475 Axon guidance
R-HSA-5621480 Dectin-2 family
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-69231 Cyclin D associated events in G1
R-HSA-1280218 Adaptive Immune System
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-162582 Signal Transduction
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-1266738 Developmental Biology
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-449147 Signaling by Interleukins
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-69236 G1 Phase
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-453279 Mitotic G1-G1/S phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

Alternate Gene Symbols: A0AVQ5, ENST00000519728.1, ENST00000519728.2, ENST00000519728.3, ENST00000519728.4, ENST00000519728.5, JTK8, LYN_HUMAN, NM_002350, P07948, uc323srg.1
UCSC ID: ENST00000519728.6_9
RefSeq Accession: NM_002350
Protein: P07948 (aka LYN_HUMAN)

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