Human Gene LRRN3 (ENST00000308478.10_3) from GENCODE V45lift37
  Description: Homo sapiens leucine rich repeat neuronal 3 (LRRN3), transcript variant 2, mRNA. (from RefSeq NM_001099658)
Gencode Transcript: ENST00000308478.10_3
Gencode Gene: ENSG00000173114.13_6
Transcript (Including UTRs)
   Position: hg19 chr7:110,731,183-110,765,510 Size: 34,328 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr7:110,762,829-110,764,955 Size: 2,127 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2024-04-24 11:59:55

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:110,731,183-110,765,510)mRNA (may differ from genome)Protein (708 aa)
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AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHuman Cortex Gene ExpressionMGIPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LRRN3_HUMAN
DESCRIPTION: RecName: Full=Leucine-rich repeat neuronal protein 3; AltName: Full=Neuronal leucine-rich repeat protein 3; Short=NLRR-3; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane ; Single-pass type I membrane protein

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): LRRN3
CDC HuGE Published Literature: LRRN3
Positive Disease Associations: Blood Pressure , Body Height , Creatinine
Related Studies:
  1. Blood Pressure
    , , . [PubMed 0]
  2. Body Height
    , , . [PubMed 0]
  3. Body Height
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.34 RPKM in Adrenal Gland
Total median expression: 125.77 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -189.20818-0.231 Picture PostScript Text
3' UTR -92.90555-0.167 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000483 - Cys-rich_flank_reg_C
IPR003961 - FN3_dom
IPR036116 - FN3_sf
IPR007110 - Ig-like_dom
IPR036179 - Ig-like_dom_sf
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR032675 - LRR_dom_sf
IPR000372 - LRRNT

Pfam Domains:
PF00041 - Fibronectin type III domain
PF07679 - Immunoglobulin I-set domain
PF13855 - Leucine rich repeat

ModBase Predicted Comparative 3D Structure on Q9H3W5
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0051965 positive regulation of synapse assembly

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF384849 - JP 2014500723-A/192352: Polycomb-Associated Non-Coding RNAs.
MA620426 - JP 2018138019-A/192352: Polycomb-Associated Non-Coding RNAs.
LP896457 - Sequence 1321 from Patent EP3253886.
AK001991 - Homo sapiens cDNA FLJ11129 fis, clone PLACE1006239, weakly similar to BONE PROTEOGLYCAN II PRECURSOR.
BC035133 - Homo sapiens leucine rich repeat neuronal 3, mRNA (cDNA clone MGC:43233 IMAGE:5263900), complete cds.
AY358280 - Homo sapiens clone DNA32298 LRRN3 (UNQ194) mRNA, complete cds.
AK292556 - Homo sapiens cDNA FLJ77618 complete cds.
JD082354 - Sequence 63378 from Patent EP1572962.
JD105148 - Sequence 86172 from Patent EP1572962.
JD285248 - Sequence 266272 from Patent EP1572962.
JD468269 - Sequence 449293 from Patent EP1572962.
AF134481 - Homo sapiens leucine-rich repeat protein mRNA, complete cds.
AB060967 - Homo sapiens Nbla10677 mRNA for neuronal leucine-rich repeat protein-3, complete cds.
AL442092 - Homo sapiens mRNA; cDNA DKFZp761K2424 (from clone DKFZp761K2424).
JD164809 - Sequence 145833 from Patent EP1572962.
JD172573 - Sequence 153597 from Patent EP1572962.
CU690048 - Synthetic construct Homo sapiens gateway clone IMAGE:100020972 5' read LRRN3 mRNA.
JF432386 - Synthetic construct Homo sapiens clone IMAGE:100073587 leucine rich repeat neuronal 3 (LRRN3) gene, encodes complete protein.
KJ899007 - Synthetic construct Homo sapiens clone ccsbBroadEn_08401 LRRN3 gene, encodes complete protein.
CR457397 - Homo sapiens full open reading frame cDNA clone RZPDo834A0721D for gene LRRN3, leucine rich repeat neuronal 3; complete cds, incl. stopcodon.
JD237469 - Sequence 218493 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000308478.1, ENST00000308478.2, ENST00000308478.3, ENST00000308478.4, ENST00000308478.5, ENST00000308478.6, ENST00000308478.7, ENST00000308478.8, ENST00000308478.9, LRRN3_HUMAN, Nbla10363, NM_001099658, O43377, Q6I9V8, Q8IYQ6, Q9H3W5, uc317ohy.1, UNQ194/PRO220
UCSC ID: ENST00000308478.10_3
RefSeq Accession: NM_001099658
Protein: Q9H3W5 (aka LRRN3_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.