Human Gene INPP5A (ENST00000368594.8_3) from GENCODE V45lift37
Description: Homo sapiens inositol polyphosphate-5-phosphatase A (INPP5A), transcript variant 1, mRNA. (from RefSeq NM_005539) RefSeq Summary (NM_005539): The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000368594.8_3 Gencode Gene: ENSG00000068383.19_7 Transcript (Including UTRs) Position: hg19 chr10:134,351,291-134,596,984 Size: 245,694 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr10:134,351,601-134,595,445 Size: 243,845 Coding Exon Count: 15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14642
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Gene Ontology (GO) Annotations with Structured Vocabulary
Protein Q14642 (Reactome details) participates in the following event(s):
R-HSA-1855222 I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1483249 Inositol phosphate metabolism R-HSA-1430728 Metabolism