Human Gene ING2 (ENST00000302327.4_3) from GENCODE V45lift37
Description: Homo sapiens inhibitor of growth family member 2 (ING2), transcript variant 1, mRNA. (from RefSeq NM_001564) RefSeq Summary (NM_001564): This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. Gencode Transcript: ENST00000302327.4_3 Gencode Gene: ENSG00000168556.7_7 Transcript (Including UTRs) Position: hg19 chr4:184,426,211-184,433,582 Size: 7,372 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr4:184,426,349-184,432,105 Size: 5,757 Coding Exon Count: 2
ID:ING2_HUMAN DESCRIPTION: RecName: Full=Inhibitor of growth protein 2; AltName: Full=Inhibitor of growth 1-like protein; Short=ING1Lp; AltName: Full=p32; AltName: Full=p33ING2; FUNCTION: Seems to be involved in p53/TP53 activation and p53/TP53- dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). SUBUNIT: Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2. INTERACTION: Q9H160; P12004: PCNA; NbExp=3; IntAct=EBI-389787, EBI-358311; Q9H160; Q96ST3: SIN3A; NbExp=2; IntAct=EBI-389787, EBI-347218; Q9H160; Q9HCE7-2: SMURF1; NbExp=3; IntAct=EBI-389787, EBI-9845742; SUBCELLULAR LOCATION: Nucleus Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm. TISSUE SPECIFICITY: Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues. INDUCTION: Induced by the DNA-damaging agents etoposide and neocarzinostatin. DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3. DOMAIN: The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5- phosphate (PtdIns(5)P). PTM: Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. MISCELLANEOUS: [Isoform ING2b]: Low expression except in testis, where it reaches half of ING2a levels. SIMILARITY: Belongs to the ING family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="https://atlasgeneticsoncology.org/gene/40975/ING2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF12998 - Inhibitor of growth proteins N-terminal histone-binding
ModBase Predicted Comparative 3D Structure on Q9H160
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Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0006325 chromatin organization GO:0006355 regulation of transcription, DNA-templated GO:0007141 male meiosis I GO:0007165 signal transduction GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0008285 negative regulation of cell proliferation GO:0030317 flagellated sperm motility GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway GO:0031065 positive regulation of histone deacetylation GO:0040008 regulation of growth GO:0042981 regulation of apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0048133 male germ-line stem cell asymmetric division GO:0072520 seminiferous tubule development GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:2000772 regulation of cellular senescence GO:2001020 regulation of response to DNA damage stimulus GO:2001234 negative regulation of apoptotic signaling pathway
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
