ID:FGOP2_HUMAN DESCRIPTION: RecName: Full=FGFR1 oncogene partner 2; FUNCTION: May be involved in wound healing pathway. INTERACTION: Q9NVK5; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-1104764, EBI-2514791; Q9NVK5-3; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-12377025, EBI-7353612; Q9NVK5-3; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-12377025, EBI-14104088; SUBCELLULAR LOCATION: Cytoplasm TISSUE SPECIFICITY: Expressed in bone marrow, spleen and thymus. DISEASE: Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity. SIMILARITY: Belongs to the SIKE family. SEQUENCE CAUTION: Sequence=AAF29087.1; Type=Frameshift; Evidence=; Sequence=CAB56012.1; Type=Frameshift; Evidence=;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NVK5
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Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042803 protein homodimerization activity