ID:CEP55_HUMAN DESCRIPTION: RecName: Full=Centrosomal protein of 55 kDa ; Short=Cep55; AltName: Full=Up-regulated in colon cancer 6; FUNCTION: Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986). SUBUNIT: Homodimer (PubMed:16406728). Interacts (phosphorylated on Ser- 425 and Ser-428) with PLK1 (PubMed:16198290). Interacts with AKAP9/CG- NAP; the interaction occurs in interphase and is lost upon mitotic entry (PubMed:16198290). Interacts with PCNT/Kendrin; the interaction occurs in interphase and is lost upon mitotic entry (PubMed:16198290). Directly interacts with PDCD6IP; this interaction is required for PDCD6IP targeting to the midbody; CEP55 binds PDCD6IP in a 2:1 stoichiometry; PDCD6IP competes with TSG101 for the same binding site (PubMed:17853893, PubMed:17556548, PubMed:18641129, PubMed:18948538). Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding (PubMed:17853893, PubMed:17556548, PubMed:18948538). Interacts with MVB12A, VPS37B, VPS37C and VPS28 (PubMed:17853893). INTERACTION: Q53EZ4; Q9NX04: AIRIM; NbExp=6; IntAct=EBI-747776, EBI-8643161; Q53EZ4; P50995: ANXA11; NbExp=8; IntAct=EBI-747776, EBI-715243; Q53EZ4; Q5T0G8: ANXA11; NbExp=3; IntAct=EBI-747776, EBI-10245225; Q53EZ4; D3DTR7: ARHGEF15; NbExp=3; IntAct=EBI-747776, EBI-10176602; Q53EZ4; O94989: ARHGEF15; NbExp=6; IntAct=EBI-747776, EBI-740691; Q53EZ4; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-747776, EBI-747505; Q53EZ4; Q8N187: CARF; NbExp=3; IntAct=EBI-747776, EBI-745541; Q53EZ4; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-747776, EBI-11524851; Q53EZ4; Q6UXH8: CCBE1; NbExp=3; IntAct=EBI-747776, EBI-3923278; Q53EZ4; Q6UXH8-3: CCBE1; NbExp=3; IntAct=EBI-747776, EBI-12013534; Q53EZ4; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-747776, EBI-744556; Q53EZ4; Q8TD31-3: CCHCR1; NbExp=6; IntAct=EBI-747776, EBI-10175300; Q53EZ4; Q16543: CDC37; NbExp=3; IntAct=EBI-747776, EBI-295634; Q53EZ4; O75419: CDC45; NbExp=7; IntAct=EBI-747776, EBI-374969; Q53EZ4; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-747776, EBI-747776; Q53EZ4; Q8IYX8: CEP57L1; NbExp=4; IntAct=EBI-747776, EBI-1104570; Q53EZ4; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-747776, EBI-10181988; Q53EZ4; P13569: CFTR; NbExp=5; IntAct=EBI-747776, EBI-349854; Q53EZ4; P27658: COL8A1; NbExp=3; IntAct=EBI-747776, EBI-747133; Q53EZ4; P50570-2: DNM2; NbExp=3; IntAct=EBI-747776, EBI-10968534; Q53EZ4; O60941: DTNB; NbExp=3; IntAct=EBI-747776, EBI-740402; Q53EZ4; O60941-5: DTNB; NbExp=3; IntAct=EBI-747776, EBI-11984733; Q53EZ4; Q8N9N8: EIF1AD; NbExp=5; IntAct=EBI-747776, EBI-750700; Q53EZ4; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-747776, EBI-744099; Q53EZ4; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-747776, EBI-7225287; Q53EZ4; Q86YD7: FAM90A1; NbExp=6; IntAct=EBI-747776, EBI-6658203; Q53EZ4; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-747776, EBI-10244131; Q53EZ4; P51116: FXR2; NbExp=3; IntAct=EBI-747776, EBI-740459; Q53EZ4; Q8TB36: GDAP1; NbExp=3; IntAct=EBI-747776, EBI-11110431; Q53EZ4; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-747776, EBI-10181276; Q53EZ4; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-747776, EBI-2514791; Q53EZ4; O14964: HGS; NbExp=5; IntAct=EBI-747776, EBI-740220; Q53EZ4; O75031: HSF2BP; NbExp=3; IntAct=EBI-747776, EBI-7116203; Q53EZ4; P42858: HTT; NbExp=9; IntAct=EBI-747776, EBI-466029; Q53EZ4; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-747776, EBI-2556193; Q53EZ4; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-747776, EBI-2125614; Q53EZ4; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-747776, EBI-14069005; Q53EZ4; O14901: KLF11; NbExp=3; IntAct=EBI-747776, EBI-948266; Q53EZ4; P56470: LGALS4; NbExp=3; IntAct=EBI-747776, EBI-720805; Q53EZ4; Q53EV4: LRRC23; NbExp=3; IntAct=EBI-747776, EBI-13435308; Q53EZ4; Q8NDC0: MAPK1IP1L; NbExp=3; IntAct=EBI-747776, EBI-741424; Q53EZ4; P55081: MFAP1; NbExp=6; IntAct=EBI-747776, EBI-1048159; Q53EZ4; Q5JRA6-2: MIA3; NbExp=4; IntAct=EBI-747776, EBI-10244342; Q53EZ4; Q15014: MORF4L2; NbExp=6; IntAct=EBI-747776, EBI-399257; Q53EZ4; Q96HA8: NTAQ1; NbExp=5; IntAct=EBI-747776, EBI-741158; Q53EZ4; Q8WUM4: PDCD6IP; NbExp=21; IntAct=EBI-747776, EBI-310624; Q53EZ4; Q9UBV8: PEF1; NbExp=6; IntAct=EBI-747776, EBI-724639; Q53EZ4; Q13526: PIN1; NbExp=3; IntAct=EBI-747776, EBI-714158; Q53EZ4; Q3KR16: PLEKHG6; NbExp=8; IntAct=EBI-747776, EBI-10240979; Q53EZ4; Q6PIY2: POLM; NbExp=6; IntAct=EBI-747776, EBI-10253863; Q53EZ4; Q96T49: PPP1R16B; NbExp=5; IntAct=EBI-747776, EBI-10293968; Q53EZ4; Q9H3S7: PTPN23; NbExp=3; IntAct=EBI-747776, EBI-724478; Q53EZ4; Q2TAK8-2: PWWP3A; NbExp=3; IntAct=EBI-747776, EBI-10239402; Q53EZ4; Q96I25: RBM17; NbExp=8; IntAct=EBI-747776, EBI-740272; Q53EZ4; Q9NW64: RBM22; NbExp=6; IntAct=EBI-747776, EBI-2602260; Q53EZ4; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-747776, EBI-743428; Q53EZ4; O00560: SDCBP; NbExp=6; IntAct=EBI-747776, EBI-727004; Q53EZ4; P14678-2: SNRPB; NbExp=3; IntAct=EBI-747776, EBI-372475; Q53EZ4; Q13573: SNW1; NbExp=3; IntAct=EBI-747776, EBI-632715; Q53EZ4; O75177-5: SS18L1; NbExp=3; IntAct=EBI-747776, EBI-12035119; Q53EZ4; Q9Y2D8: SSX2IP; NbExp=5; IntAct=EBI-747776, EBI-2212028; Q53EZ4; P56279: TCL1A; NbExp=6; IntAct=EBI-747776, EBI-749995; Q53EZ4; D3DUQ6: TEAD4; NbExp=3; IntAct=EBI-747776, EBI-10176734; Q53EZ4; Q15561: TEAD4; NbExp=5; IntAct=EBI-747776, EBI-747736; Q53EZ4; Q8IWB6: TEX14; NbExp=5; IntAct=EBI-747776, EBI-6674697; Q53EZ4; Q92734: TFG; NbExp=6; IntAct=EBI-747776, EBI-357061; Q53EZ4; O14656-2: TOR1A; NbExp=3; IntAct=EBI-747776, EBI-25847109; Q53EZ4; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-747776, EBI-11952721; Q53EZ4; O14773: TPP1; NbExp=3; IntAct=EBI-747776, EBI-2800203; Q53EZ4; Q99816: TSG101; NbExp=24; IntAct=EBI-747776, EBI-346882; Q53EZ4; A5D8V6: VPS37C; NbExp=8; IntAct=EBI-747776, EBI-2559305; Q53EZ4; Q9Y3C0: WASHC3; NbExp=7; IntAct=EBI-747776, EBI-712969; Q53EZ4; Q96MX3: ZNF48; NbExp=3; IntAct=EBI-747776, EBI-12006434; Q53EZ4; A8K9C1; NbExp=3; IntAct=EBI-747776, EBI-10174800; SUBCELLULAR LOCATION: Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cleavage furrow Midbody, Midbody ring te=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. TISSUE SPECIFICITY: Expressed in embryonic brain (PubMed:28264986). Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex (PubMed:28264986). Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles (at protein level) (PubMed:28295209, PubMed:28264986). Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain. PTM: There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully. DISEASE: Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (MARCH) [MIM:236500]: An autosomal recessive, congenital disease characterized by severe hydranencephaly with multinucleated neurons, renal aplasia or dysplasia, and hypoplastic kidneys. Hydranencephaly is an anomaly leading to replacement of the cerebral hemispheres with a fluid-filled cyst. MARCH results in death in utero or in the perinatal period. Note=The disease is caused by variants affecting the gene represented in this entry. SEQUENCE CAUTION: Sequence=BAA91670.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence=;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q53EZ4
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Gene Ontology (GO) Annotations with Structured Vocabulary