ID:MRCKG_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase MRCK gamma; EC=2.7.11.1; AltName: Full=CDC42-binding protein kinase gamma; AltName: Full=DMPK-like gamma; AltName: Full=Myotonic dystrophy kinase-related CDC42-binding kinase gamma; Short=MRCK gamma; Short=MRCKG; Short=Myotonic dystrophy protein kinase-like gamma; AltName: Full=Myotonic dystrophy protein kinase-like alpha; FUNCTION: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; ACTIVITY REGULATION: Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation (By similarity). SUBUNIT: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42 (By similarity). INTERACTION: Q6DT37; Q9UHD2: TBK1; NbExp=3; IntAct=EBI-689124, EBI-356402; SUBCELLULAR LOCATION: Cytoplasm Note=Concentrates at the leading edge of cells. TISSUE SPECIFICITY: Expressed in heart and skeletal muscle. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00130 - Phorbol esters/diacylglycerol binding domain (C1 domain) PF00780 - CNH domain PF08826 - DMPK coiled coil domain like PF00069 - Protein kinase domain PF00433 - Protein kinase C terminal domain
ModBase Predicted Comparative 3D Structure on Q6DT37
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Gene Ontology (GO) Annotations with Structured Vocabulary
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
