ID:5MP1_HUMAN DESCRIPTION: RecName: Full=eIF5-mimic protein 1 ; AltName: Full=Basic leucine zipper and W2 domain-containing protein 2; FUNCTION: Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:34260931, PubMed:29470543). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C- binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931). SUBUNIT: Interacts with EIF3E (PubMed:21745818). Interacts with EIF2S2 (PubMed:21745818, PubMed:25147208, PubMed:34260931). Interacts with EIF3C (PubMed:34260931). INTERACTION: Q9Y6E2; P20042: EIF2S2; NbExp=2; IntAct=EBI-1051021, EBI-711977; SUBCELLULAR LOCATION: Cytoplasm SIMILARITY: Belongs to the BZW family. SEQUENCE CAUTION: Sequence=AAI07758.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence=;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y6E2
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Gene Ontology (GO) Annotations with Structured Vocabulary