Human Gene ACAN (ENST00000560601.4_7) from GENCODE V45lift37
Description: Homo sapiens aggrecan (ACAN), transcript variant 3, mRNA. (from RefSeq NM_001369268) RefSeq Summary (NM_001369268): This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000560601.4_7 Gencode Gene: ENSG00000157766.19_14 Transcript (Including UTRs) Position: hg19 chr15:89,346,667-89,418,584 Size: 71,918 Total Exon Count: 19 Strand: + Coding Region Position: hg19 chr15:89,379,438-89,417,712 Size: 38,275 Coding Exon Count: 18
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on H0YMF1
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005509 calcium ion binding GO:0005540 hyaluronic acid binding