Description

This column shows the similarity of the expression of each gene to the selected gene. Genes with identical expression profiles show a value of 0. This column shows data only for the 1000 genes (including splicing variants) that have the most similar expression profiles.

Methods

The expression distance between two genes is a weighted sum computed with the following formula:

     delta(a,b) = sum(w[i] * |a[i] - b[i]| ) / sum(w[i])

where a and b are expression vectors associated with the two genes indexed by tissue, w is an array of weights, and the sums are taken over all tissues. When there are multiple replicants for a tissue the median value is used. The values for the weights are 0.1 for the cancer cell lines and 0.5 for the brain and nervous system derived tissues (since these are overrepresented). The weights for the ovary-derived tissues are 0.5 for the one labeled 'ovary' and 0.25 each for the OVR278E and OVR278S. The other tissues are all weighted 1.0.